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GLASS

You can:

Check the ligand table for details.
Go to the GPCR list to see GPCRs with which this ligand interacts.
Go to the individual GPCR page for PubMed ID information by text mining.
Download a TSV version of all interaction data.
Go back to previous page.

Ligand

Name	CHEMBL57364
Molecular formula	C21H28ClN3O2
IUPAC name	8-[2-[4-(3-chlorophenyl)piperazin-1-yl]ethyl]-8-azaspiro[4.5]decane-7,9-dione
Molecular weight	389.924
Hydrogen bond acceptor	4
Hydrogen bond donor	0
XlogP	3.5
Synonyms	8-{2-[4-(3-Chloro-phenyl)-piperazin-1-yl]-ethyl}-8-aza-spiro[4.5]decane-7,9-dione BDBM50026941
Inchi Key	ATIJQZLSMDZBIR-UHFFFAOYSA-N
Inchi ID	InChI=1S/C21H28ClN3O2/c22-17-4-3-5-18(14-17)24-11-8-23(9-12-24)10-13-25-19(26)15-21(16-20(25)27)6-1-2-7-21/h3-5,14H,1-2,6-13,15-16H2
PubChem CID	12840735
ChEMBL	CHEMBL57364
IUPHAR	N/A
BindingDB	50026941
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Known GPCRs

You can:

Click GLASS IDs to check the association information.
Click protein names to check details of the GPCRs.
Download a TSV version of all interaction information.

GLASS ID	Name	UniProt	Gene	Species	Length
13976	5-hydroxytryptamine receptor 1A	P08908	HTR1A	Homo sapiens (Human)	422
13978	Alpha-1A adrenergic receptor	P43140	Adra1a	Rattus norvegicus (Rat)	466
13977	Alpha-1B adrenergic receptor	P35368	ADRA1B	Homo sapiens (Human)	520
13975	Alpha-1D adrenergic receptor	P23944	Adra1d	Rattus norvegicus (Rat)	561

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