GLASS 2.0

GLASS 2.0 is an updated database of experimentally validated GPCR–ligand interactions. It is constructed through a hybrid approach that combines curated data integration from major public resources—including BindingDB, ChEMBL, DrugBank, IUPHAR, and PDSP—with large language model (LLM)-powered text mining of primary literature. Compared to its predecessor (GLASS 1.0), GLASS 2.0 features a more than 50% increase in data volume, along with rigorous deduplication and normalization of experimental values, units, and identifiers. The database also offers optimized classification and regression datasets tailored for AI research, as well as newly resolved protein structures and computationally generated ligand conformations. (>> more about GLASS 2.0)

Find your GPCR interaction

Explore GPCR-ligand interactions with brand new GLASS 2.0

Update History

NEW! June 28, 2025
The brand-new GLASS 2.0 website was officially launched, featuring updated datasets, a redesigned user interface, and specially curated classification and regression datasets for AI study!
June 21, 2025 🎉GLASS 2.0!
Recompile and update GLASS database, incorporating LLM-based text mining, resulting in a 53% increase in data volume.
July 13, 2018
Add TSV files for interaction data filtered (by Kd, Ki, IC50, EC50) for active and inactive compounds in 'Download' section.
July 12, 2018
Replaced JMol viewer with NGL viewer. All GPCR structures are now loaded directly from GPCR-EXP, a new database we developed for experimentally-solved and predicted GPCR structures.
November 2, 2017
Fixed bug in update script that missed BioLiP entries from 2015 and onwards.
October 4, 2017
Fixed bug where searching with a ligand name as a query could result in an internal server error. Also fixed problem where synonym lists would not expand when clicked.
February 14, 2017
Happy Valentine's Day! The browse ligand and browse family features have been fixed. Thank you to Hongjiu Zhang for assistance.
August 5, 2016
Added 2D molecule structures to GPCR search results. Thank you to Dr. Andrew Horti for this useful suggestion. This change should hopefully facilitate the browsing of molecules.
June 24, 2016
Fixed bug where DrugBank entries were not showing up.
March 1, 2015
Redesigned the database schemas.
February 17, 2015
Migrated the website to the new framework.
August 12, 2014
Added searches for GPCR by family and for ligands by chemical structure.
June 30, 2014
Added batch TSV and SDF download.
June 28, 2014
Added synonyms for GPCRs and ligands, as well as Lipinski's rule of five check.
June 24, 2014
Set up the database website.

Internal Resources

GPCR-EXP: A semi-manually curated database for experimentally-solved and predicted GPCR structures GPCRRD: GPCR 3D restraint database GPCR-I-TASSER: 3D structure prediction of GPCRs UniBioMap: Comprehensive Protein & Compound Centered Biomedical Knowledge Graph GLASS 1.0: GPCR-ligand Association Database

Browse the Database

Explore our complete collection of GPCRs, ligands, and families