GPCR-I-TASSER results for P51810

[Click on P51810_results.tar.bz2 to download the tarball file including all modeling results listed on this page]

  Submitted Sequence

>P51810
MASPRLGTFCCPTRDAATQLVLSFQPRAFHALCLGSGGLRLALGLLQLLPGRRPAGPGSP
ATSPPASVRILRAAAACDLLGCLGMVIRSTVWLGFPNFVDSVSDMNHTEIWPAAFCVGSA
MWIQLLYSACFWWLFCYAVDAYLVIRRSAGLSTILLYHIMAWGLATLLCVEGAAMLYYPS
VSRCERGLDHAIPHYVTMYLPLLLVLVANPILFQKTVTAVASLLKGRQGIYTENERRMGA
VIKIRFFKIMLVLIICWLSNIINESLLFYLEMQTDINGGSLKPVRTAAKTTWFIMGILNP
AQGFLLSLAFYGWTGCSLGFQSPRKEIQWESLTTSAAEGAHPSPLMPHENPASGKVSQVG
GQTSDEALSMLSEGSDASTIEIHTASESCNKNEGDPALPTHGDL

  Predicted Secondary Structure

Sequence                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280                 300                 320                 340                 360                 380                 400
                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |    
MASPRLGTFCCPTRDAATQLVLSFQPRAFHALCLGSGGLRLALGLLQLLPGRRPAGPGSPATSPPASVRILRAAAACDLLGCLGMVIRSTVWLGFPNFVDSVSDMNHTEIWPAAFCVGSAMWIQLLYSACFWWLFCYAVDAYLVIRRSAGLSTILLYHIMAWGLATLLCVEGAAMLYYPSVSRCERGLDHAIPHYVTMYLPLLLVLVANPILFQKTVTAVASLLKGRQGIYTENERRMGAVIKIRFFKIMLVLIICWLSNIINESLLFYLEMQTDINGGSLKPVRTAAKTTWFIMGILNPAQGFLLSLAFYGWTGCSLGFQSPRKEIQWESLTTSAAEGAHPSPLMPHENPASGKVSQVGGQTSDEALSMLSEGSDASTIEIHTASESCNKNEGDPALPTHGDL
PredictionCCCCCCCCSSCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCSSHHHHHHHHHHHHHHHHHHHHHHHHHHHSSSSCCCCCCSSHCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
Conf.Score99977675436877734566553040477743499999999999998877765056654200344234899999999999999999999999988888753553057767787763899999999999999999999999986146656540311103456388899999988740367765210146422899999999999999999999999999999999875043257889999999999999999999999999999999876401211012200000027999999999999999999999999876344763203212214576777778857899878889999876788888894443046999887755045664445756689898254779

  Predicted Solvent Accessibility

Sequence                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280                 300                 320                 340                 360                 380                 400
                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |    
MASPRLGTFCCPTRDAATQLVLSFQPRAFHALCLGSGGLRLALGLLQLLPGRRPAGPGSPATSPPASVRILRAAAACDLLGCLGMVIRSTVWLGFPNFVDSVSDMNHTEIWPAAFCVGSAMWIQLLYSACFWWLFCYAVDAYLVIRRSAGLSTILLYHIMAWGLATLLCVEGAAMLYYPSVSRCERGLDHAIPHYVTMYLPLLLVLVANPILFQKTVTAVASLLKGRQGIYTENERRMGAVIKIRFFKIMLVLIICWLSNIINESLLFYLEMQTDINGGSLKPVRTAAKTTWFIMGILNPAQGFLLSLAFYGWTGCSLGFQSPRKEIQWESLTTSAAEGAHPSPLMPHENPASGKVSQVGGQTSDEALSMLSEGSDASTIEIHTASESCNKNEGDPALPTHGDL
Prediction72424242000223342132234022300000000000000000000000222344333333133010000000000101011011120001000120031023133342221000100000000001000000000030000000233433101000000012001000200001113333101000200001011132122200220210000001101221343344345532420330010001003003300210010101212232333133332331320100000000100031000000001002422341424434241542433444443434333344443443434544434431433446363344413443443447434424554355
Values range from 0 (buried residue) to 9 (highly exposed residue)

   Predicted normalized B-factor


  Top 10 templates used by GPCR-I-TASSER

Rank PDB
Hit		Iden1Iden2Cov.Norm.
Z-score		Download
Align.		                   20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280                 300                 320                 340                 360                 380                 400
                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |    
Sec.Str
Seq		CCCCCCCCSSCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCSSHHHHHHHHHHHHHHHHHHHHHHHHHHHSSSSCCCCCCSSHCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
MASPRLGTFCCPTRDAATQLVLSFQPRAFHALCLGSGGLRLALGLLQLLPGRRPAGPGSPATSPPASVRILRAAAACDLLGCLGMVIRSTVWLGFPNFVDSVSDMNHTEIWPAAFCVGSAMWIQLLYSACFWWLFCYAVDAYLVIRRSAGLSTILLYHIMAWGLATLLCVEGAAMLYYPSVSRCERGLDHAIPHYVTMYLPLLLVLVANPILFQKTVTAVASLLKGRQGIYTENERRMGAVIKIRFFKIMLVLIICWLSNIINESLLFYLEMQTDINGGSLKPVRTAAKTTWFIMGILNPAQGFLLSLAFYGWTGCSLGFQSPRKEIQWESLTTSAAEGAHPSPLMPHENPASGKVSQVGGQTSDEALSMLSEGSDASTIEIHTASESCNKNEGDPALPTHGDL
14k5yA 0.14 0.17 0.61 2.78Download --------------------------HVAAIINYLGHCISLVALLVAFVLFLR------ARSIRCLRNIIHANLIAAFILRNATWFVVQLTMSPEVH------------QSNVGWCRLVTAAYNYFHVTNFFWMFGEGCYLHTAIV-LTDRLRAWMFICIGWGVPFPIIVAWAIGKLYYDNEKCWAGKRPGVYTDYIYQGPMALVLLINFIFLFNIVRILMTKL----RASTTSETIQARKAVKATLVLLPLLGITYMLAFV-----------------NPGEDEVSRVVFIYFNAFLESFQGFFVSVFACFLN------------------------------------------------------------------------------------------
23wajA 0.09 0.22 0.92 1.99Download SNFPHRIWFDPFTYYPYGSYTATSGESLRAVLAFIPAIGGVLAILPVYLLTREVFD------------KRAAVIAAFLIAIVPGQFLQWEAFWQVSALGTFLLAYNRWKGHDLTAGITIGLYVLSWGAGFIIAPIILAFMFFAFVLAGFVNADRKNLSLVAVVTFAVSALIYLPFAFNYPGFSTIFYS--------PFQLLVLLGSAVIAAAFYQIEKWNDVGFFERVGLGRKGMPLAVIVLTALIMGLFFVLTNAVLHFGALFFFGMAGILYSAYRFLKRRSFPEMALLIWAIAMFIALYSALALSVVFDKLHFRVAFALLIALAAIYPTYILADAQSSYAGGPNKQWYDALTWMRENTPDGEKYDEYYLQLYPTPQ-----------SNKEPFSYPFETYQA
34k5yA 0.14 0.15 0.61 1.51Download ------------------------HYHVAAIINYLGHCISLVALLVAFVLFLRAR------SIRCLRNIIHANLIAAFILRNATWFVVQLTMSP-----EVHQSNVG-------WCRLVTAAYNYFHVTNFFWMFGEGCYLHTAIVDAYDRLRAWMFICIGWGVPFPIIVAWAIGKLYYDNEKCWAGKRPGVYTDYIYQGPMALVLLINFIFLFNIVRILMTKLRASTT----SETIQARKAVKATLVLLPLLGITYMLAFV---------------------NEVSRVVFIYFNAFLESFQGFFVSVFACFLNS-----------------------------------------------------------------------------------------
44o9rA 0.13 0.19 0.87 2.14Download TDNPEDVEGCGIQCQNP-L-FTEAEHQDMHSYIAAFGAVTGLCTLFTLATFVADWRNS-----NRYPAVILFYVNACFFVGSIGWLAQFMDG--A---RREIVRADGEPSNETLSCVIIFVIVYYALMAGVVWFVVLTYAWHTSFK-----GKTSYFHLLTWSLPFVLTVAILAVAQVDVSGICFVGYKNYRYRAGFVLAPIGLVLIVGGYFLIRGVMTLFSIKSNHADLEDNETLNDNLKVIEDALTKMPEMGFDILVGQIDDALKLANEGQATRNAYIQAKINLRLGIFGFLAFGFV------LITFSCHFYDFFNQAEWERSFRDYQANVTI--------PD--CEIKNRPSLLAMTGIAMSTW--VWTKATLLIWRRTWCR-------------------
54l6rA 0.14 0.18 0.70 1.54Download -------------EVQKEVAKMYSSFQVMYTVGYSLSLGALLLALAILGGLSKLHC---------TRNAIHANLFASFVLKASSVLVIDGLLR-------------TLSDGAVAGCRVAAVFMQYGIVANYCWLLVEGLYLHNLLGLLPERSFFSLYLGIGWGAPMLFVVPWAVVKCLFENVQCWTSNDN-MGFWWILRFPVFLAILINFFIFVRIVQLLVAKLRARQMHHT----DYKFRLAKSTLTLIPLLGVHEVVFAF---------------VTDEHAQGTLRSAKLFFDLFLSSFQGLLVAVLYCFLNKEVQSELRRRWHRWRLGKVLWEERN-----------------------------------------------------------------
64bvnA 0.16 0.17 0.66 2.47Download ----------------LSQQ----WEAGMSLLMALVVLLIVAGNVLVIAAIGS---TQRLQ---TLTNLFITSLACADLVVGLLVVPFGATL-----------VVRGTWLWGSFLCELWTSLDVLCVTASVETLCVIAIDRYLAITSPFRYARAKVIICTVWAISALVSFLPIMMHWWDQALKCDFNRAYAIASSISFYIPLLIMIFVALRVYREAKEQIRK------RKTSRVMLMREHKALKTLGIIMGVFTLCWLPFFLVNIVNVFNRDL------VPKWLFVAFNWLGYANSAMNPILC-RSPDFR-----------KAFKRLLA---------------------------------------------------------------------------
74k5yA 0.14 0.17 0.61 4.62Download ------------------------HYHVAAIINYLGHCISLVALLVAFVLFLRARS------IRCLRNIIHANLIAAFILRNATWFVVQL------------TMSPEVHQSNVGWCRLVTAAYNYFHVTNFFWMFGEGCYLHTAIVLTYDRLRAWMFICIGWGVPFPIIVAWAIGKLYYDNEKCWAGKRPGVYTDYIYQGPMALVLLINFIFLFNIVRILMTKLRAST----TSETIQARKAVKATLVLLPLLGITYMLAFVN---------------------EVSRVVFIYFNAFLESFQGFFVSVFACFLNS-----------------------------------------------------------------------------------------
84l6rA 0.14 0.18 0.70 2.25Download ---------------QKEVAKMYSSFQVMYTVGYSLSLGALLLALAILGGLSKLHC---------TRNAIHANLFASFVLKASSVLVIDGLLR-------------TLSDGAVAGCRVAAVFMQYGIVANYCWLLVEGLYLHNLLGLLPERSFFSLYLGIGWGAPMLFVVPWAVVKCLFENVQCW-TSNDNMGFWWILRFPVFLAILINFFIFVRIVQLLVAKLRARQM----HHTDYKFRLAKSTLTLIPLLGVHEVVFAF---------------VTDEHAQGTLRSAKLFFDLFLSSFQGLLVAVLYCFLNKEVQSELRRRWHRWRLGKVLWEERN-----------------------------------------------------------------
94l6rA 0.14 0.20 0.73 2.88Download TTRNAYIQKYLDGEEIEVQKEVAKMYSSFQVMYTVGYSLSLGALLLALAILGGLSK------LHCTRNAIHANLFASFVLKASSVLVIDGLLRT---------------DGAVAGCRVAAVFMQYGIVANYCWLLVEGLYLHNLLGLATLRSFFSLYLGIGWGAPMLFVVPWAVVKCLFEN--VQCWTSNDNGFWWILRFPVFLAILINFFIFVRIVQLLVAKLRARQM----HHTDYKFRLAKSTLTLIPLLGVHEVVFAFVT----------DEHA-----QGTLRSAKLFFDLFLSSFQGLLVAVLYCFLNKEVQSELRRRWHRWLGKVLWEERN------------------------------------------------------------------
104k5yA 0.15 0.15 0.59 2.02Download -----------------------------HYLGHCISLVALLVAFVLFLRARSIRC---------LRNIIHANLIAAFILRNATWFVVQLTMS------------PEVHQSNVGWCRLVTAAYNYFHVTNFFWMFGEGCYLHTAIVLT-DRLRAWMFICIGWGVPFPIIVAWAIGKLYYDNEKCWAGKRPGVYTDYIYQGPMALVLLINFIFLFNIVRILMTK----LRASTTSETIQARKAVKATLVLLPLLGITYMLAFVN---------------------EVSRVVFIYFNAFLESFQGFFVSVFACFLNS-----------------------------------------------------------------------------------------
(a)All the residues are colored in black; however, those residues in template which are identical to the residue in the query sequence are highlighted in color. Coloring scheme is based on the property of amino acids, where polar are brightly coloured while non-polar residues are colored in dark shade. (more about the colors used)
(b)Rank of templates represents the top ten threading templates used by GPCR-I-TASSER.
(c)Ident1 is the percentage sequence identity of the templates in the threading aligned region with the query sequence.
(d)Ident2 is the percentage sequence identity of the whole template chains with query sequence.
(e)Cov. represents the coverage of the threading alignment and is equal to the number of aligned residues divided by the length of query protein.
(f)Norm. Z-score is the normalized Z-score of the threading alignments. Alignment with a Normalized Z-score >1 mean a good alignment and vice versa.
(g)Download Align. provides the 3D structure of the aligned regions of the threading templates.
(h)The top 10 alignments reported above (in order of their ranking) are from the following threading programs:
       1: FFAS-3D   2: PROSPECT2   3: SPARKS-X   4: HHSEARCH I   5: MUSTER   6: HHSEARCH2   7: HHSEARCH I   8: Neff-PPAS   9: HHSEARCH   10: pGenTHREADER   

  Top 5 Models predicted by GPCR-I-TASSER

Generated 3D models Estimated local accuracy of models
  • Download Model 1
  • C-score=-2.35 (Read more about C-score)
  • Estimated TM-score = 0.44±0.14
  • Estimated RMSD = 12.5±4.3Å




    •  Please cite following articles when you use the GPCR-I-TASSER server:
    J Zhang, J Yang, R Jang, Y Zhang. Hybrid structure modeling of G protein-coupled receptors in the human genome, submitted (2015).