GPCR-I-TASSER results for Q6ZMH4

[Click on Q6ZMH4_results.tar.bz2 to download the tarball file including all modeling results listed on this page]

  Submitted Sequence

>Q6ZMH4
METYSLSLGNQSVVEPNIAIQSANFSSENAVGPSNVRFSVQKGASSSLVSSSTFIHTNVD
GLNPDAQTELQVLLNMTKNYTKTCGFVVYQNDKLFQSKTFTAKSDFSQKIISSKTDENEQ
DQSASVDMVFSPKYNQKEFQLYSYACVYWNLSAKDWDTYGCQKDKGTDGFLRCRCNHTTN
FAVLMTFRKDYQYPKSLDILSNVGCALSVTGLALTVIFQIVTRKVRKTSVTWVLVNLCIS
MLIFNLLFVFGIENSNKNLQTSDGDINNIDFDNNDIPRTDTINIPNPMCTAIAALLHYFL
LVTFTWNALSAAQLYYLLIRTMKPLPRHFILFISLIGWGVPAIVVAITVGVIYSQNGNNP
QWELDYRQEKICWLAIPEPNGVIKSPLLWSFIVPVTIILISNVVMFITISIKVLWKNNQN
LTSTKKVSSMKKIVSTLSVAVVFGITWILAYLMLVNDDSIRIVFSYIFCLFNTTQGLQIF
ILYTVRTKVFQSEASKVLMLLSSIGRRKSLPSVTRPRLRVKMYNFLRSLPTLHERFRLLE
TSPSTEEITLSESDNAKESI

  Predicted Secondary Structure

Sequence                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280                 300                 320                 340                 360                 380                 400                 420                 440                 460                 480                 500                 520                 540                 560
                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |
METYSLSLGNQSVVEPNIAIQSANFSSENAVGPSNVRFSVQKGASSSLVSSSTFIHTNVDGLNPDAQTELQVLLNMTKNYTKTCGFVVYQNDKLFQSKTFTAKSDFSQKIISSKTDENEQDQSASVDMVFSPKYNQKEFQLYSYACVYWNLSAKDWDTYGCQKDKGTDGFLRCRCNHTTNFAVLMTFRKDYQYPKSLDILSNVGCALSVTGLALTVIFQIVTRKVRKTSVTWVLVNLCISMLIFNLLFVFGIENSNKNLQTSDGDINNIDFDNNDIPRTDTINIPNPMCTAIAALLHYFLLVTFTWNALSAAQLYYLLIRTMKPLPRHFILFISLIGWGVPAIVVAITVGVIYSQNGNNPQWELDYRQEKICWLAIPEPNGVIKSPLLWSFIVPVTIILISNVVMFITISIKVLWKNNQNLTSTKKVSSMKKIVSTLSVAVVFGITWILAYLMLVNDDSIRIVFSYIFCLFNTTQGLQIFILYTVRTKVFQSEASKVLMLLSSIGRRKSLPSVTRPRLRVKMYNFLRSLPTLHERFRLLETSPSTEEITLSESDNAKESI
PredictionCCSSSCCCCSSSSSSSSSSSSSSCCCCCCCCCCCCSSSSSCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHCCCCCCCSSSSSSSSCCCCCCCCCCCCCCCCCCCSSSSSSSCCCCCCCCCCSSSSSSSCCCCCCCCCCCCSSSSSCCCCCCCCCCCCSSSCCSCCSSSSSCCCCCCCCCCCCCCCCCCCCCHHSSCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHCCCCCCCCSSSSSSSSCCCCSSSSSSSSSSSSSCCCCCCCCCCCCCCCCCSSSSCCCCCCCCCCCCSSSSSSCCHHHHHHHHHHHHHHHHHHHSSSCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHSSSSSSSCCCCCHHHHHHHHHHHHHHHHHHHHHHSSSSCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCSSCCCCCCCCCCC
Conf.Score95486047614898222789997567555567542687622678765124531346653446854111023453047777669999995788646587877645655659999948987767885489999603567777668542347189996268898892001887437547766324343332231101121230256789999999999999874302446765207889999999999998876764222321102233322100222101234445632478999999999999999999999999972021000455413798874102313589999999985035666544323465313575146645301463468873003553354278899998744121024345410888888762244699887436216899853798189999999999998899887222335589999999999773436688787888668877625447778898856772015898852533116677767889

  Predicted Solvent Accessibility

Sequence                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280                 300                 320                 340                 360                 380                 400                 420                 440                 460                 480                 500                 520                 540                 560
                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |
METYSLSLGNQSVVEPNIAIQSANFSSENAVGPSNVRFSVQKGASSSLVSSSTFIHTNVDGLNPDAQTELQVLLNMTKNYTKTCGFVVYQNDKLFQSKTFTAKSDFSQKIISSKTDENEQDQSASVDMVFSPKYNQKEFQLYSYACVYWNLSAKDWDTYGCQKDKGTDGFLRCRCNHTTNFAVLMTFRKDYQYPKSLDILSNVGCALSVTGLALTVIFQIVTRKVRKTSVTWVLVNLCISMLIFNLLFVFGIENSNKNLQTSDGDINNIDFDNNDIPRTDTINIPNPMCTAIAALLHYFLLVTFTWNALSAAQLYYLLIRTMKPLPRHFILFISLIGWGVPAIVVAITVGVIYSQNGNNPQWELDYRQEKICWLAIPEPNGVIKSPLLWSFIVPVTIILISNVVMFITISIKVLWKNNQNLTSTKKVSSMKKIVSTLSVAVVFGITWILAYLMLVNDDSIRIVFSYIFCLFNTTQGLQIFILYTVRTKVFQSEASKVLMLLSSIGRRKSLPSVTRPRLRVKMYNFLRSLPTLHERFRLLETSPSTEEITLSESDNAKESI
Prediction64323242232111211010101304343134332121213434343213333143443541434442314222423553111000000323300326534443312010000002363441433030202031344445333110000012333133330233233431010100100000101112122201200110000000000000000000000111211112000000000000000000000010012202111000000000111002122232220000000000000000000000000000000000002122112000000000000000000000001122333231222201110000003211000200000000000000001000000000000002223324434222112101000000000010000000001332101000000000000300000000000125400410230021023334434343433333333232333334334432333443433342334646446636
Values range from 0 (buried residue) to 9 (highly exposed residue)

   Predicted normalized B-factor


  Top 10 templates used by GPCR-I-TASSER

Rank PDB
Hit		Iden1Iden2Cov.Norm.
Z-score		Download
Align.		                   20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280                 300                 320                 340                 360                 380                 400                 420                 440                 460                 480                 500                 520                 540                 560
                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |
Sec.Str
Seq		CCSSSCCCCSSSSSSSSSSSSSSCCCCCCCCCCCCSSSSSCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHCCCCCCCSSSSSSSSCCCCCCCCCCCCCCCCCCCSSSSSSSCCCCCCCCCCSSSSSSSCCCCCCCCCCCCSSSSSCCCCCCCCCCCCSSSCCSCCSSSSSCCCCCCCCCCCCCCCCCCCCCHHSSCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHCCCCCCCCSSSSSSSSCCCCSSSSSSSSSSSSSCCCCCCCCCCCCCCCCCSSSSCCCCCCCCCCCCSSSSSSCCHHHHHHHHHHHHHHHHHHHSSSCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHSSSSSSSCCCCCHHHHHHHHHHHHHHHHHHHHHHSSSSCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCSSCCCCCCCCCCC
METYSLSLGNQSVVEPNIAIQSANFSSENAVGPSNVRFSVQKGASSSLVSSSTFIHTNVDGLNPDAQTELQVLLNMTKNYTKTCGFVVYQNDKLFQSKTFTAKSDFSQKIISSKTDENEQDQSASVDMVFSPKYNQKEFQLYSYACVYWNLSAKDWDTYGCQKDKGTDGFLRCRCNHTTNFAVLMTFRKDYQYPKSLDILSNVGCALSVTGLALTVIFQIVTRKVRKTSVTWVLVNLCISMLIFNLLFVFGIENSNKNLQTSDGDINNIDFDNNDIPRTDTINIPNPMCTAIAALLHYFLLVTFTWNALSAAQLYYLLIRTMKPLPRHFILFISLIGWGVPAIVVAITVGVIYSQNGNNPQWELDYRQEKICWLAIPEPNGVIKSPLLWSFIVPVTIILISNVVMFITISIKVLWKNNQNLTSTKKVSSMKKIVSTLSVAVVFGITWILAYLMLVNDDSIRIVFSYIFCLFNTTQGLQIFILYTVRTKVFQSEASKVLMLLSSIGRRKSLPSVTRPRLRVKMYNFLRSLPTLHERFRLLETSPSTEEITLSESDNAKESI
14l6rA 0.16 0.17 0.57 3.15Download -------------------------------------------------------------------------------------------------------------------------------------------------------NEGKVKEAQAAAEQLKTTRNAYIQKYLMDGEEIEVQKEVAKMYSSFQVMYTVGYSLSLGALLLALAILGGLSKLHCTR-NAIHANLFASFVLKASSVLVIDGLLR-----------------------TLSDGAVAGCRVAAVFMQYGIVANYCWLLVEGLYLHNLLGLATLPE-RSFFSLYLGIGWGAPMLFVVPWAVVKCLFENVQ------------CWTSNDN------MGFWWILRFPVFLAILINFFIFVRIVQLLVAKL-RARQMHHTDYKFRLAKSTLTLIPLLGVHEVVFAFVTDEHAQLRSAKLFFDLFLSSFQGLLVAVLYCFLNKEVQSELRRRWHRWRLGKVLWEERN------------------------------------------------
24k5yA 0.18 0.12 0.45 1.42Download ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HYHVAAIINYLGHCISLVALLVAFVLFLRARSIRC-LRNIIHANLIAAFILRNATWFVVQLTMSPEVHQSNV----------------------GWCRLVTAAYNYFHVTNFFWMFGEGCYLHTAIVL-WDAYDRLRAWMFICIGWGVPFPIIVAWAIGKLYYDNEK------------CWAGKRPGVYTD-----YIYQGPMALVLLINFIFLFNIVRILMTKL-RASTTSETIQARKAVKATLVLLPLLGITYMLAFV----NEVSRVVFIYFNAFLESFQGFFVSVFACFLNS------------------------------------------------------------------------
34l6rA 0.16 0.17 0.70 1.39Download -----------------------------------------------------------ADLEDNWETLNDNLKVIEKADNA--------------AQVKDALTKMRAAALDAQKATPEDKSPDSPEMK---DFRHGFDILVGQIDDALKLNEGKVKEAQAAAEQLKTTRNAYIQKYLMDGEEIEVQKEVAKMYSSFQVMYTVGYSLSLGALLLALAILGGLSKLHCT-RNAIHANLFASFVLKASSVLVIDGLLRT-----------------------LSDGAVAGCRVAAVFMQYGIVANYCWLLVEGLYLHNLLGLATLPE-RSFFSLYLGIGWGAPMLFVVPWAVVKCLFENVQCWTSND------------------NMGFWWILRFPVFLAILINFFIFVRIVQLLVAKLRARQMHHT-DYKFRLAKSTLTLIPLLGVHEVVFAFVTDEHATLRSAKLFFDLFLSSFQGLLVAVLYCFLNKEVQSELRRRWHRWRLGKVLWEERN------------------------------------------------
44l6rA 0.16 0.17 0.69 3.37Download ---------------------------------------------------------------ADLEDNWETLNDNKKADNAA----QVKD-AL---------TKMRAAALDAQKATPPDKPDSPEMKDFRHGFDILV-GQIDDALKLANE--GKVKEAEQLKTTRNAYIQKYLMDGEEIEVQ----KEVAKMYSSFQVMYTVGYSLSLGALLLALAILGGLSKLHCTR-NAIHANLFASFVLKASSVLVIDGLLR---T----------------LS----DGAVAGCRVAAVFMQYGIVANYCWLLVEGLYLHNLLGLATLPE-RSFFSLYLGIGWGAPMLFVVPWAVVKCL-----------FEN-VQCWTSNDNM------GFWWILRFPVFLAILINFFIFVRIVQLLVAKLRARQ-MHHTDYKFRLAKSTLTLIPLLGVHEVVFAFVTDEHATLRSAKLFFDLFLSSFQGLLVAVLYCFLNKEVQSELRRRWHRWRLGKVLWEERN------------------------------------------------
54k5yA 0.19 0.17 0.44 4.88Download ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HYHVAAIINYLGHCISLVALLVAFVLFLRARSIRCL-RNIIHANLIAAFILRNATWFVVQLTMSP----------------------EVHQSNVGWCRLVTAAYNYFHVTNFFWMFGEGCYLHTAIVLTFEAYDRLRAWMFICIGWGVPFPIIVAWAIGK--L----------YYDNEKCWAGKRP-------GVYYIYQGPMALVLLINFIFLFNIVRILMTKLRAS-TTSETIQARKAVKATLVLLPLLGITYMLAFVN----EVSRVVFIYFNAFLESFQGFFVSVFACFLNS------------------------------------------------------------------------
64l6rA 0.14 0.17 0.69 2.59Download -----------------------------------------------------------------------------ADLEDNWETLNDNLKVIEKADNAAQVKDALTKMRAAALDKLEDKSPDS---PEMKDFRHGFDILVGQIDDALKLAEGKVKEAQAAAEQLKTTRNAYIQKYLMDGEEIEVQKEVAKMYSSFQVMYTVGYSLSLGALLLALAILGGLSK-LHCTRNAIHANLFASFVLKASSVLVIDGLLR-----------------------TLSDGAVAGCRVAAVFMQYGIVANYCWLLVEGLYLHNLLGLATLPERSFF-SLYLGIGWGAPMLFVVPWAVVKCLFENVQCWTSND------------------NMGFWWILRFPVFLAILINFFIFVRIVQLLV-AKLRARQMHHTDYKFRLAKSTLTLIPLLGVHEVVFAFVTDEHATLRSAKLFFDLFLSSFQGLLVAVLYCFLNKEVQSELRRRWHRWRLGKVLWEERN------------------------------------------------
74k5yA 0.18 0.17 0.44 6.00Download ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HYHVAAIINYLGHCISLVALLVAFVLFLRARSIRCLR-NIIHANLIAAFILRNATWFVVQLTMS----------------------PEVHQSNVGWCRLVTAAYNYFHVTNFFWMFGEGCYLHTAIVLTFEMYDRLRAWMFICIGWGVPFPIIVAWAIG--K----------LYYDNEKCWAGKRPG-------VYYIYQGPMALVLLINFIFLFNIVRILMTKLRAST-TSETIQARKAVKATLVLLPLLGITYMLAFVN----EVSRVVFIYFNAFLESFQGFFVSVFACFLNS------------------------------------------------------------------------
84k5yA 0.19 0.12 0.44 1.65Download ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HYHVAAIINYLGHCISLVALLVAFVLFLRARSIRC-LRNIIHANLIAAFILRNATWFVVQLTMSPEVHQSNV----------------------GWCRLVTAAYNYFHVTNFFWMFGEGCYLHTAIVLTDRLRAWMFIC----IGWGV------------PFPIIVAWAIGKLYYDNEKCWAGKRP-----GVYTDYIYQGPMALVLLINFIFLFNIVRILMTKLRA-STTSETIQARKAVKATLVLLPLLGITYMLAFV----NEVSRVVFIYFNAFLESFQGFFVSVFACFLNS------------------------------------------------------------------------
94l6rA 0.16 0.17 0.69 1.88Download ------------------------------------------------------------------------------ADLEDNWETLNDNLKVIEKADNAAQVKMRAAALDAQKATPEDKSPDSPEMK----FRHGFDILVGQIDDALKLAEGKVKEAQAAAEQLKTTRNAYIQKYLMDGEEIEVQKEVAKMYSSFQVMYTVGYSLSLGALLLALAILGGLSKLHCT-RNAIHANLFASFVLKASSVLVIDGLLR-----------------------TLSDGAVAGCRVAAVFMQYGIVANYCWLLVEGLYLHNLLGLATLPE-RSFFSLYLGIGWGAPMLFVVPWAVVKCLFENVQ------------CWTSNDN------MGFWWILRFPVFLAILINFFIFVRIVQLLVAKLRARQMHHTD-YKFRLAKSTLTLIPLLGVHEVVFAFVTDEHAQLRSAKLFFDLFLSSFQGLLVAVLYCFLNKEVQSELRRRWHRWRLGKVLWEERN------------------------------------------------
103txaA 0.05 0.19 0.88 1.85Download AQ----YPKSAIYEDTKENYPLVNVEGSKVGEQYKALNPINGKDGRREIAEGWLSKKI-------------TGVNDLDKNKYKIELTVEGKTTVETKELNQPLTSNKDNRVALVTYASTIFDGTEATVSKGVADQNGK--------ALNDSVSWDYHKTTFTATTHNYSYLNLTND--------------------------------ANEVNILKSRIPKEAEHINGDRTLYQFGATFTQKALMKANEILETQSSNARKKLIFHVTDGVPTMSYAINFNPYISTSYQNQFNSFLNKIPDRSGILQEDFIINGDDYQIVKGDGESFKLFSDRKVPVTGGTTQAAYRVPQNQLEGYAINSGYIYLYWRDYNWVYPFDPKTKKVSATKQIKTHGEPTTLYFNGNIRPKGYDIFTVGIGVNGDPGATPLEAE--------KFMQSISSKTENYTNVDDTNKIYDELNKYFKTIVEEKHSIVDGNVTDPMGEMIEFQLKNGQSFTHDDYVLVGNDGSQLKNGVALGGPNSDGGILKDVTVTYDKTSQNRTTLSPKSEKEPNTIV
(a)All the residues are colored in black; however, those residues in template which are identical to the residue in the query sequence are highlighted in color. Coloring scheme is based on the property of amino acids, where polar are brightly coloured while non-polar residues are colored in dark shade. (more about the colors used)
(b)Rank of templates represents the top ten threading templates used by GPCR-I-TASSER.
(c)Ident1 is the percentage sequence identity of the templates in the threading aligned region with the query sequence.
(d)Ident2 is the percentage sequence identity of the whole template chains with query sequence.
(e)Cov. represents the coverage of the threading alignment and is equal to the number of aligned residues divided by the length of query protein.
(f)Norm. Z-score is the normalized Z-score of the threading alignments. Alignment with a Normalized Z-score >1 mean a good alignment and vice versa.
(g)Download Align. provides the 3D structure of the aligned regions of the threading templates.
(h)The top 10 alignments reported above (in order of their ranking) are from the following threading programs:
       1: FFAS-3D   2: SPARKS-X   3: MUSTER   4: HHSEARCH2   5: HHSEARCH I   6: Neff-PPAS   7: HHSEARCH   8: pGenTHREADER   9: wdPPAS   10: PROSPECT2   

  Top 5 Models predicted by GPCR-I-TASSER

Generated 3D models Estimated local accuracy of models
  • Download Model 1
  • C-score=-3.21 (Read more about C-score)
  • Estimated TM-score = 0.36±0.12
  • Estimated RMSD = 15.7±3.3Å

  • Download Model 2
  • C-score = -3.36

  • Download Model 3
  • C-score = -3.54

  • Download Model 4
  • C-score = -4.01

  • Download Model 5
  • C-score = -3.94




    •  Please cite following articles when you use the GPCR-I-TASSER server:
    J Zhang, J Yang, R Jang, Y Zhang. Hybrid structure modeling of G protein-coupled receptors in the human genome, submitted (2015).