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I-TASSER results for job id S692800

(Click on S692800_results.tar.bz2 to download the tarball file including all modeling results listed on this page. Click on Annotation of I-TASSER Output to read the instructions for how to interpret the results on this page. Model results are kept on the server for 60 days, there is no way to retrieve the modeling data older than 2 months)

  Submitted Sequence in FASTA format

>protein
CGLAMTAAYVPEAKAVSVQEYQQKVASHADLKSKLAGVNSALANQIIELDSLANEQIPAA
QEAATKAQQAAQQAQDLADATTERLNAAKKDKADLEQKIKDTGIEYDDAKDSVAESARDS
FHGSQASTVMSVVTNATTTDDFVNQMQSDAAATRSAANAANEAAISMNTSMNRKDRLAAI
EDQITQLKNQADKQAASAQAAAEDAAAKQASLEALQAKGTAARESLESQKSSLTTQEAKE
AADIASLQAQLASQSTSNNYTPGSGGQQQSSGGSTGGYTGGGSTSTGGTSSGGSTSGGST
GGGTANGMDYAVPGSCPEGSSFCYGHNTGNTVGGSAYPARQCTLWAYIRRSQLSLPVGSY
MGNGGQWAATARGL

  Predicted Secondary Structure

Sequence                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280                 300                 320                 340                 360
                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |              
CGLAMTAAYVPEAKAVSVQEYQQKVASHADLKSKLAGVNSALANQIIELDSLANEQIPAAQEAATKAQQAAQQAQDLADATTERLNAAKKDKADLEQKIKDTGIEYDDAKDSVAESARDSFHGSQASTVMSVVTNATTTDDFVNQMQSDAAATRSAANAANEAAISMNTSMNRKDRLAAIEDQITQLKNQADKQAASAQAAAEDAAAKQASLEALQAKGTAARESLESQKSSLTTQEAKEAADIASLQAQLASQSTSNNYTPGSGGQQQSSGGSTGGYTGGGSTSTGGTSSGGSTSGGSTGGGTANGMDYAVPGSCPEGSSFCYGHNTGNTVGGSAYPARQCTLWAYIRRSQLSLPVGSYMGNGGQWAATARGL
PredictionCCCSSSCCCCCHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCSSSHHHHCCCCCCCCCCCCCCCHHHHHHHHCCC
Conf.Score92032235530210043999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999998377531899987589889999999999999999999999999999999989999999999999999999999999999999999999999999999999999999999988777766766898888788887653022410000145665555677789988887778878788998888888886623355767777766777877767887231673442223035523689787667775786521469
H:Helix; S:Strand; C:Coil

  Predicted Solvent Accessibility

Sequence                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280                 300                 320                 340                 360
                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |              
CGLAMTAAYVPEAKAVSVQEYQQKVASHADLKSKLAGVNSALANQIIELDSLANEQIPAAQEAATKAQQAAQQAQDLADATTERLNAAKKDKADLEQKIKDTGIEYDDAKDSVAESARDSFHGSQASTVMSVVTNATTTDDFVNQMQSDAAATRSAANAANEAAISMNTSMNRKDRLAAIEDQITQLKNQADKQAASAQAAAEDAAAKQASLEALQAKGTAARESLESQKSSLTTQEAKEAADIASLQAQLASQSTSNNYTPGSGGQQQSSGGSTGGYTGGGSTSTGGTSSGGSTSGGSTGGGTANGMDYAVPGSCPEGSSFCYGHNTGNTVGGSAYPARQCTLWAYIRRSQLSLPVGSYMGNGGQWAATARGL
Prediction30000001323433444364145345425524541462455045235414523654155035414513541451354154135414514543551453046246414513640352034215655324203111327414401421411330243145315413543443453444144135414513541453344344335424533541441353254135414533441443343344334414542443444444444544444444444444434333343333334333333333232312223232313223323232322211201010100000001222222013112200001102341447
Values range from 0 (buried residue) to 9 (highly exposed residue)

   Predicted normalized B-factor

(B-factor is a value to indicate the extent of the inherent thermal mobility of residues/atoms in proteins. In I-TASSER, this value is deduced from threading template proteins from the PDB in combination with the sequence profiles derived from sequence databases. The reported B-factor profile in the figure below corresponds to the normalized B-factor of the target protein, defined by B=(B'-u)/s, where B' is the raw B-factor value, u and s are respectively the mean and standard deviation of the raw B-factors along the sequence. Click here to read more about predicted normalized B-factor)


  Top 10 threading templates used by I-TASSER

(I-TASSER modeling starts from the structure templates identified by LOMETS from the PDB library. LOMETS is a meta-server threading approach containing multiple threading programs, where each threading program can generate tens of thousands of template alignments. I-TASSER only uses the templates of the highest significance in the threading alignments, the significance of which are measured by the Z-score, i.e. the difference between the raw and average scores in the unit of standard deviation. The templates in this section are the 10 best templates selected from the LOMETS threading programs. Usually, one template of the highest Z-score is selected from each threading program, where the threading programs are sorted by the average performance in the large-scale benchmark test experiments.)

Rank PDB
Hit
Iden1Iden2CovNorm.
Z-score
Download
Align.
                   20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280                 300                 320                 340                 360
                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |              
Sec.Str
Seq
CCCSSSCCCCCHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCSSSHHHHCCCCCCCCCCCCCCCHHHHHHHHCCC
CGLAMTAAYVPEAKAVSVQEYQQKVASHADLKSKLAGVNSALANQIIELDSLANEQIPAAQEAATKAQQAAQQAQDLADATTERLNAAKKDKADLEQKIKDTGIEYDDAKDSVAESARDSFHGSQASTVMSVVTNATTTDDFVNQMQSDAAATRSAANAANEAAISMNTSMNRKDRLAAIEDQITQLKNQADKQAASAQAAAEDAAAKQASLEALQAKGTAARESLESQKSSLTTQEAKEAADIASLQAQLASQSTSNNYTPGSGGQQQSSGGSTGGYTGGGSTSTGGTSSGGSTSGGSTGGGTANGMDYAVPGSCPEGSSFCYGHNTGNTVGGSAYPARQCTLWAYIRRSQLSLPVGSYMGNGGQWAATARGL
16tpiA 0.13 0.22 0.90 1.80Download ----------------------------------LKSIQADIAAKERAVRQK-QQQRASLLAQLKKQEEAISEATRKLRETQNTLNQLNKQIDEMNASIAKLEQQKAAQERSLAAQLDAAFRQGEHTG-IQLILSGEESQRGQRLQAYFGYLNQARQETIAQLKQTREEVAMQRAELEEKQSEQQTLLYEQRAQQAKLTQALNERKKTLAGLESSIQQGQQQLSELRANESRLRNSIARAEAAAKARAEREAREAQAVRDRQKEATRKGTTYKPTEGAPRGQAFWPVRGPTLHRYGEQLQGELRWKGMVIGASEGTEVKAIADGRVILADWLQGYGHGKGDMS--LYGYNQSALVSVGSQVRAGQPIALVGSS-
24cgk 0.14 0.24 0.74 3.81Download ----------------------------SNLTAQQQEAQKQVDQIQEQVSAIQA----------------------EQSNLQAENDRLQAESKKLEGEITELSKNIVSRNQSLEKQARSAQTNGAVTSYINTIVNSKSITEAISRVAAMSEIVSANNKMLEQQKADKKAISEKQVANNDAINT------------VIANQ--QKLADDAQALTTKQAELKAAELSLAAEKATAEGEKASLLEQKAAAEAEARAAAVAEAAYKEKRAQQQSV-L--A-SA---NTNLT----AQVQA--VSE---------S-AAAPVRAKVRPTYSTNA-----SSYPIGECTWGVKTLAPWA----GDYWGNGAQWATSAAAA
37p3rA 0.10 0.18 0.69 1.26Download DWFDDLSKKLDSAKLVAKQWIDTFQASIDAIHELYKATVQQASQIMTALSSQVSGIEATVKGMNKELSDWGVKMQAAHDDLVNGIIDLQTDIESMNNAIDNNRAAIEKLNKDLVYAQVAVGVGIFMLVAGVALTVATAAAVSGGIAAVGAASIIAGGVTWGVLQNQIDDDYDSIAQEQKQKAEDQQQIIALQGLSNASSAVVSAIETSTSVLSDFETTWTVFGNELDDVVTKLNNQSIIMEKVMSDAAKNEWDDAVELA-------------------------------------------------------------------------------------------------------------------
46tpi 0.13 0.22 0.90 2.24Download ----------------------------------LKSIQADIAAKERAVRQ-KQQQRASLLAQLKKQEEAISEATRKLRETQNTLNQLNKQIDEMNASIAKLEQQKAAQERSLAAQLDAAFRQGEHT-GIQLILSGEESQRGQRLQAYFGYLNQARQETIAQLKQTREEVAMQRAELEEKQSEQQTLLYEQRAQQAKLTQALNERKKTLAGLESSIQQGQQQLSELRANESRLRNSIARAEAAAKARAEREAREAQAVRDRQKEATRKGTTYKPTGGLGAPRGQAFWPVRTLHRYGEQLQGELRWKGMVIGASEGTEVKAIGRVILADWLQGYGLEHGKGDMSLYGY--NQSALVSVGSQVRAGQPIALVGSSG
55xg2A 0.12 0.13 0.63 2.45Download ----------------TKGAIVRWGKRKEKLIEEIRAREEERNALVVRLGEI-DRTFAVAREEFDTVVKELEEARKSLYEGEARIKRAEEEKERLKAEILTGEARLPGLRERAENLRRLVEEKRAEISELERRLSSIT--------SQSFELRIKLSDLEKELELARKDLEKVLAEERAVREEIEVAKRRINELDTLIERERGELAKLRGRIERLERKRDKLKKALENEARELTEKIRAVEKEIAALREELSRVEGKLEGL-----------------------------------------------------------------------------------------------------------------
66tpi 0.15 0.22 0.18 3.00Download -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ELRWKGMVIGASEGTEVKAIADGRVILALQGYGVEHGKGDMSLYGYN--QSALVSVGSQVRAGQPIALVG---
74cgkA 0.13 0.24 0.86 1.11Download --------------------------------------------------SNLTAQQQEAQKQVDQIQEQVSAIQAEQSNLQAENDRLQAESKKLEGEITELSKNIVSRNQSLEKQARSAQTNGAVTSYINTIVNSKSITEAISRVAAMSEIVSANNKMLEQQKADKKAISEKQVANNDAINTVIANQQKLADDAQALTTKQAELKAAELSLAAEKATAEGEKASLLEQKAAAEAEARAAAVAEAAYKEKRASQQQSVLASANTNLTAQVQAVSESAAAPVRAKVRPTYSTNASSYPIGETLAPWAGDYWGNGAQWAAGFRTGSTPQVGAIANDGGY--GHVAVVTAVESTT-RIQVSESNYAGNRTIGNHRGW
87p3rA 0.10 0.18 0.69 1.91Download FLILNTQFTPPTVKPDWFDDLSTTVQQASQIMTALSSQVSGIEATVKGMNKELSDWGVKMQAAHDDLVNGATNIQKTIIDLQTDIESMNNAIDNNRAAIEKLNKDLVYAQVAVGVGIFMLVAG----VALTVATAGTAAAVSGGIAAVGAASIIAGGVTWGVLQNQIDDDYDSIAQEQKQKAEDQQQIIALQGLSNASSAVVSAIETSTSVLSDFETTWTVFGNELDDVVTKLNNGASMQSIIMEKVMSDAAKN---------------------------------------------------------------------------------------------------------------EWDDAVELA
97cbcA 0.11 0.19 0.82 1.12Download -----------SELARKLLEASTKLQRLNIRLAEALLEAARLQELNLELVYLAVE-LTDPKRIRDEIKEVKDKSKEIIRRAEKEIDDAAKESEKILEEAREASYLAKLLLKAIAETQDLNLRAAKAFLEAAAKL-QELNIRAVELLVKLYDPATIREALEHAKRRSKEIIDEAERAIRAAKRESERIIEEARRLIESGSELARELLRAHAQLQRLNLELLRELLRALAQLQELNLDLLRLASELTDPDEARKAIARSKRESKRIVEDAERGGGTFACRIAAKIAAEFGYSEEQIKELLKNAGCSEDEARDAVEYLRSRPGL-----------------------------------------------------
106ewyA 0.12 0.18 0.52 1.76Download --------------------------------DTIAALIADVAK--------ANQRLQDLSDEVQAEQESVNKAMVDVETARDNAAAAEDDLEVSQRAVKDANAAIAAAQHRFDTFAAATYMNGPSVS----YLSASSPDEIIATVTAAKTLSASSQAVMANLQRARTERVNTESAARLAKQKADKAAADAKASQDAAVAALTETRRKFDEQREEVQRLAAERDAAQARLQAARLVAW----------------------------------------------------------------------------------------------------------------------------------------
(a)All the residues are colored in black; however, those residues in template which are identical to the residue in the query sequence are highlighted in color. Coloring scheme is based on the property of amino acids, where polar are brightly coloured while non-polar residues are colored in dark shade. (more about the colors used)
(b)Rank of templates represents the top ten threading templates used by I-TASSER.
(c)Ident1 is the percentage sequence identity of the templates in the threading aligned region with the query sequence.
(d)Ident2 is the percentage sequence identity of the whole template chains with query sequence.
(e)Cov represents the coverage of the threading alignment and is equal to the number of aligned residues divided by the length of query protein.
(f)Norm. Z-score is the normalized Z-score of the threading alignments. Alignment with a Normalized Z-score >1 mean a good alignment and vice versa.
(g)Download Align. provides the 3D structure of the aligned regions of the threading templates.
(h)The top 10 alignments reported above (in order of their ranking) are from the following threading programs:
       1: FFAS-3D   2: HHSEARCH2   3: SPARKS-X   4: HHSEARCH I   5: pGenTHREADER   6: HHSEARCH   7: wdPPAS   8: PROSPECT2   9: SP3   10: FFAS-3D   

   Top 5 final models predicted by I-TASSER

(For each target, I-TASSER simulations generate a large ensemble of structural conformations, called decoys. To select the final models, I-TASSER uses the SPICKER program to cluster all the decoys based on the pair-wise structure similarity, and reports up to five models which corresponds to the five largest structure clusters. The confidence of each model is quantitatively measured by C-score that is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [-5, 2], where a C-score of a higher value signifies a model with a higher confidence and vice-versa. TM-score and RMSD are estimated based on C-score and protein length following the correlation observed between these qualities. Since the top 5 models are ranked by the cluster size, it is possible that the lower-rank models have a higher C-score in rare cases. Although the first model has a better quality in most cases, it is also possible that the lower-rank models have a better quality than the higher-rank models as seen in our benchmark tests. If the I-TASSER simulations converge, it is possible to have less than 5 clusters generated; this is usually an indication that the models have a good quality because of the converged simulations.)
    (By right-click on the images, you can export image file or change the configurations, e.g. modifying the background color or stopping the spin of your models)
  • Download Model 1
  • C-score=-1.60 (Read more about C-score)
  • Estimated TM-score = 0.52±0.15
  • Estimated RMSD = 10.4±4.6Å

  • Download Model 2
  • C-score = -2.97

  • Download Model 3
  • C-score = -3.10

  • Download Model 4
  • C-score = -3.33

  • Download Model 5
  • C-score = -3.47


  Proteins structurally close to the target in the PDB (as identified by TM-align)

(After the structure assembly simulation, I-TASSER uses the TM-align structural alignment program to match the first I-TASSER model to all structures in the PDB library. This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e. the highest TM-score, to the predicted I-TASSER model. Due to the structural similarity, these proteins often have similar function to the target. However, users are encouraged to use the data in the next section 'Predicted function using COACH' to infer the function of the target protein, since COACH has been extensively trained to derive biological functions from multi-source of sequence and structure features which has on average a higher accuracy than the function annotations derived only from the global structure comparison.)


Top 10 Identified stuctural analogs in PDB

Click
to view
RankPDB HitTM-scoreRMSDaIDENaCovAlignment
16tpiA0.844 2.210.1220.901Download
21ciiA0.464 4.190.0220.564Download
37ogtA0.451 4.840.0460.588Download
46gy6B0.435 4.520.0700.553Download
56yvuB0.429 4.220.0420.540Download
66el1O0.421 4.310.0690.532Download
73vkgA0.409 5.470.0340.575Download
86ek4A0.408 3.630.0770.492Download
95xg2A0.406 3.610.1260.481Download

(a)Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)RMSDa is the RMSD between residues that are structurally aligned by TM-align.
(d)IDENa is the percentage sequence identity in the structurally aligned region.
(e)Cov represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.


  Predicted function using COFACTOR and COACH

(This section reports biological annotations of the target protein by COFACTOR and COACH based on the I-TASSER structure prediction. While COFACTOR deduces protein functions (ligand-binding sites, EC and GO) using structure comparison and protein-protein networks, COACH is a meta-server approach that combines multiple function annotation results (on ligand-binding sites) from the COFACTOR, TM-SITE and S-SITE programs.)

  Ligand binding sites


Click
to view
RankC-scoreCluster
size
PDB
Hit
Lig
Name
Download
Complex
Ligand Binding Site Residues
10.08 3 1ji4A FE Rep, Mult 111,115
20.05 2 2w6dB CPL Rep, Mult 116,117,118,119,120,121,122
30.05 2 3tijA DMU Rep, Mult 106,113
40.05 2 2q6qA CO Rep, Mult 97,101
50.03 1 3rk2B CA Rep, Mult 83,86


Download the residue-specific ligand binding probability, which is estimated by SVM.
Download the all possible binding ligands and detailed prediction summary.
Download the templates clustering results.
(a)C-score is the confidence score of the prediction. C-score ranges [0-1], where a higher score indicates a more reliable prediction.
(b)Cluster size is the total number of templates in a cluster.
(c)Lig Name is name of possible binding ligand. Click the name to view its information in the BioLiP database.
(d)Rep is a single complex structure with the most representative ligand in the cluster, i.e., the one listed in the Lig Name column.
Mult is the complex structures with all potential binding ligands in the cluster.

  Enzyme Commission (EC) numbers and active sites


Click
to view
RankCscoreECPDB
Hit
TM-scoreRMSDaIDENaCovEC NumberActive Site Residues
10.1152iw5A0.371 5.700.0780.529 1.-.-.-  286
20.1101mhsA0.311 6.660.0610.497 3.6.3.6  NA
30.1042b5uA0.328 4.010.0540.401 3.1.-.-  NA
40.1011p49A0.318 6.250.0640.497 3.1.6.2  NA
50.1001yrqI0.309 6.180.0440.460 1.12.2.1  NA

 Click on the radio buttons to visualize predicted active site residues.
(a)CscoreEC is the confidence score for the EC number prediction. CscoreEC values range in between [0-1];
where a higher score indicates a more reliable EC number prediction.
(b)TM-score is a measure of global structural similarity between query and template protein.
(c)RMSDa is the RMSD between residues that are structurally aligned by TM-align.
(d)IDENa is the percentage sequence identity in the structurally aligned region.
(e)Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided
by length of the query protein.

  Gene Ontology (GO) terms
Top 10 homologous GO templates in PDB 
RankCscoreGOTM-scoreRMSDaIDENaCovPDB HitAssociated GO Terms
1 0.140.4641 4.19 0.02 0.561ciiA GO:0019835 GO:0042742 GO:0005886 GO:0016020 GO:0016021 GO:0050829
2 0.130.3893 5.21 0.08 0.542ch7A GO:0004871 GO:0005515 GO:0006935 GO:0007165 GO:0016020
3 0.110.3728 3.01 0.07 0.423l4qC GO:0005942 GO:0035014
4 0.110.3726 5.61 0.07 0.532x0lA GO:0050660 GO:0019899 GO:0043392 GO:0005515 GO:0043518 GO:0034339 GO:0034648 GO:0045892 GO:0003700 GO:0005634 GO:0006355 GO:0007596 GO:0008134 GO:0030374 GO:0016577 GO:0032091 GO:0043433 GO:0043066 GO:0034720 GO:0016491 GO:0051577 GO:0000122 GO:0021983 GO:0033169 GO:0005654 GO:0006351 GO:0003682 GO:0000790 GO:0002039 GO:0016568 GO:0005667 GO:0055114 GO:0032452 GO:0008283 GO:0045944 GO:0032453 GO:0044212 GO:0032451 GO:0051091 GO:0001701 GO:0046886 GO:0007275 GO:0055001 GO:0006482 GO:0032454 GO:0050681
5 0.100.3401 6.01 0.05 0.511miuA GO:0000724 GO:0003697 GO:0005634 GO:0006310 GO:0007090
6 0.100.3276 4.01 0.05 0.402b5uA GO:0019835 GO:0016787 GO:0004519 GO:0042742 GO:0005515 GO:0004518 GO:0003676 GO:0003723 GO:0005727 GO:0009405 GO:0016788 GO:0043022
7 0.100.3180 6.25 0.06 0.501p49A GO:0007565 GO:0043588 GO:0008284 GO:0005635 GO:0008544 GO:0043434 GO:0005764 GO:0005792 GO:0005789 GO:0005783 GO:0008484 GO:0008202 GO:0007611 GO:0004773 GO:0014070 GO:0046872 GO:0009268 GO:0016021 GO:0043627 GO:0005886 GO:0006706 GO:0006629 GO:0016020 GO:0016787 GO:0005624 GO:0005768 GO:0000299 GO:0005794 GO:0003824 GO:0008152
8 0.100.3276 3.37 0.04 0.383qa8A GO:0004672 GO:0004674 GO:0005524 GO:0006468 GO:0016772
9 0.100.3192 5.66 0.04 0.483g67A GO:0004871 GO:0007165 GO:0016020
10 0.100.2640 6.34 0.05 0.412j68A GO:0006184 GO:0003924 GO:0005525


Consensus prediction of GO terms
 
Molecular Function GO:0004871 GO:0035014 GO:0034648 GO:0050681 GO:0019899 GO:0003700 GO:0003682 GO:0044212 GO:0032454 GO:0030374
GO-Score 0.13 0.11 0.11 0.11 0.11 0.11 0.11 0.11 0.11 0.11
Biological Process GO:0050829 GO:0019835 GO:0006935 GO:0007596 GO:0055001 GO:0043392 GO:0034720 GO:0032091 GO:0001701 GO:0043433
GO-Score 0.14 0.14 0.13 0.11 0.11 0.11 0.11 0.11 0.11 0.11
Cellular Component GO:0043231
GO-Score 0.41

(a)CscoreGO is a combined measure for evaluating global and local similarity between query and template protein. It's range is [0-1] and higher values indicate more confident predictions.
(b)TM-score is a measure of global structural similarity between query and template protein.
(c)RMSDa is the RMSD between residues that are structurally aligned by TM-align.
(d)IDENa is the percentage sequence identity in the structurally aligned region.
(e)Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.
(f)The second table shows a consensus GO terms amongst the top scoring templates. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on CscoreGO of the template.


[Click on S692800_results.tar.bz2 to download the tarball file including all modeling results listed on this page]



Please cite the following articles when you use the I-TASSER server:
  • Wei Zheng, Chengxin Zhang, Yang Li, Robin Pearce, Eric W. Bell, Yang Zhang. Folding non-homology proteins by coupling deep-learning contact maps with I-TASSER assembly simulations. Cell Reports Methods, 1: 100014 (2021).
  • Chengxin Zhang, Peter L. Freddolino, and Yang Zhang. COFACTOR: improved protein function prediction by combining structure, sequence and protein-protein interaction information. Nucleic Acids Research, 45: W291-299 (2017).
  • Jianyi Yang, Yang Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015.