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I-TASSER results for job id S692909

[Click on S692909_results.tar.bz2 to download the tarball file including all modeling results listed on this page]


  Submitted Sequence in FASTA format

>protein
MATKAVCVLKGDGPVQGIINFEQKESNGPVKVWGSIKGLTEGLHGFHVHEFGDNTAGCTS
AGPHFNPLSRKHGGPKDEERHVGDLGNVTADKDGVADVSIEDSVISLSGDHCIIGRTLVV
HEKADDLGKGGNEESTKTGNAGSRLACGVIGIAQ

  Predicted Secondary Structure

Sequence                  20                  40                  60                  80                 100                 120                 140
                   |                   |                   |                   |                   |                   |                   |              
MATKAVCVLKGDGPVQGIINFEQKESNGPVKVWGSIKGLTEGLHGFHVHEFGDNTAGCTSAGPHFNPLSRKHGGPKDEERHVGDLGNVTADKDGVADVSIEDSVISLSGDHCIIGRTLVVHEKADDLGKGGNEESTKTGNAGSRLACGVIGIAQ
PredictionCCCSSSSSSCCCCCCSSSSSSSSSCCCCSSSSSSSSCCCCCCCSSSSSSCCCCCCCCCHHHHHHCCCCCCCCCCCCCCCCCCCCSSSSSSCCCCSSSSSSSSCCSSSCCCCCCCCCSSSSSSCCCCCCCCCCCCCCCCCCCCCCSSSSSSSSSC
Conf.Score9836999982799868999999957999699999968889974548991889689970111001033333257976566554425448978997799999989768258766687789997526665556565665668987718999998639
H:Helix; S:Strand; C:Coil

  Predicted Solvent Accessibility

Sequence                  20                  40                  60                  80                 100                 120                 140
                   |                   |                   |                   |                   |                   |                   |              
MATKAVCVLKGDGPVQGIINFEQKESNGPVKVWGSIKGLTEGLHGFHVHEFGDNTAGCTSAGPHFNPLSRKHGGPKDEERHVGDLGNVTADKDGVADVSIEDSVISLSGDHCIIGRTLVVHEKADDLGKGGNEESTKTGNAGSRLACGVIGIAQ
Prediction6443010103274514020202034773303030304614433100000030423541400000112763613324575200000110303552403130314304033444030200000033024353647423633422311000001328
Values range from 0 (buried residue) to 9 (highly exposed residue)

   Predicted normalized B-factor

(B-factor is a value to indicate the extent of the inherent thermal mobility of residues/atoms in proteins. In I-TASSER, this value is deduced from threading template proteins from the PDB in combination with the sequence profiles derived from sequence databases. The reported B-factor profile in the figure below corresponds to the normalized B-factor of the target protein, defined by B=(B'-u)/s, where B' is the raw B-factor value, u and s are respectively the mean and standard deviation of the raw B-factors along the sequence. Click here to read more about predicted normalized B-factor)


  Top 10 threading templates used by I-TASSER

(I-TASSER modeling starts from the structure templates identified by LOMETS from the PDB library. LOMETS is a meta-server threading approach containing multiple threading programs, where each threading program can generate tens of thousands of template alignments. I-TASSER only uses the templates of the highest significance in the threading alignments, the significance of which are measured by the Z-score, i.e. the difference between the raw and average scores in the unit of standard deviation. The templates in this section are the 10 best templates selected from the LOMETS threading programs. Usually, one template of the highest Z-score is selected from each threading program, where the threading programs are sorted by the average performance in the large-scale benchmark test experiments.)

Rank PDB
Hit
Iden1Iden2CovNorm.
Z-score
Download
Align.
                   20                  40                  60                  80                 100                 120                 140
                   |                   |                   |                   |                   |                   |                   |              
Sec.Str
Seq
CCCSSSSSSCCCCCCSSSSSSSSSCCCCSSSSSSSSCCCCCCCSSSSSSCCCCCCCCCHHHHHHCCCCCCCCCCCCCCCCCCCCSSSSSSCCCCSSSSSSSSCCSSSCCCCCCCCCSSSSSSCCCCCCCCCCCCCCCCCCCCCCSSSSSSSSSC
MATKAVCVLKGDGPVQGIINFEQKESNGPVKVWGSIKGLTEGLHGFHVHEFGDNTAGCTSAGPHFNPLSRKHGGPKDEERHVGDLGNVTADKDGVADVSIEDSVISLSGDHCIIGRTLVVHEKADDLGKGGNEESTKTGNAGSRLACGVIGIAQ
12xjlA 0.95 0.95 0.99 3.64Download -ATKAVAVLKGDGPVQGIINFEQKESNGPVKVWGSIKGLTEGLHGFSVSEEEDNTAGCTSAGPHFNPLSRKHGGPKDEERHVGDLGNVTADKDGVADVSIEDSVISLSGDHAIIGRTLVVSEKADDLGKGGNEESTKTGNAGSRLACGVIGIAQ
27fh6A 0.13 0.36 0.93 0.72Download EYDAWLVKLNKDGQTDWVRQFGT----PNYDFMWDIETDSLGDIYATGWTLGDLGGKNA--GSYYNTNGNQIKQFGTSEDDAPFLDGIDIDANDNIFLTGNTN-GNLGGANAGSYDAWAAKFD----KDGNQLWLKQFGTPDYDTATTVTAVNF
36foi 0.99 0.98 0.99 2.21Download -ATKAVCVLKGDGPVQGIINFEQKESNGPVKVWGSIKGLTEGLHGFHVHEFGDNTAGATSAGPHFNPLSRKHGGPKDEERHVGDLGNVTADKDGVADVSIEDSVISLSGDHCIIGRTLVVHEKADDLGKGGNEESTKTGNAGSRLAAGVIGIAQ
44a7uA 0.99 0.99 0.99 4.02Download -ATKAVCVLKGDGPVQGIINFEQKESNGPVKVWGSIKGLTEGLHGFHVHEFGDNTAGCTSAGPHFNPLSRKHGGPKDEERHVGDLGNVTADKDGVADVSIEDSVISLSGDHCITGRTLVVHEKADDLGKGGNEESTKTGNAGSRLACGVIGIAQ
52nnxA 0.99 0.98 0.99 3.04Download -ATKAVCVLKGDGPVQGIINFEQKESNGPVKVWGSIKGLTEGLHGFRVQEFGDNTAGCTSAGPHFNPLSRKHGGPKDEERHVGDLGNVTADKDGVADVSIEDSVISLSGDHCIIGRTLVVHEKADDLGKGGNEESTKTGNAGSRLACGVIGIAQ
67ljgA 0.08 0.23 0.94 0.73Download IRSKSTARWNMQTGKVGTVHISYNSVAKRLSAVVSYSGKTADANSLHFSFNKFSQNPKDLILQGDAFTDSDGNLQLTKVSGNSVGRALFYEKSAVVASFDATFTFLIKSPDREPADGITFFIANTDTSIPSGSGGRLLGLFPD---------AN
71xsoA 0.67 0.66 0.97 5.64Download --VKAVCVLAGSGDVKGVVHFEQQDEG-AVSVEGKIEGLTDGLHGFHIHVFGDNTNGCMSAGSHFNPENKNHGAPGDTDRHVGDLGNVTAE-GGVAQFKITDSLISLKGPNSIIGRTAVVHEKADDLGKGGNDESLKTGNAGGRLACGVIGYSP
86foiA 0.99 0.98 0.99 4.86Download -ATKAVCVLKGDGPVQGIINFEQKESNGPVKVWGSIKGLTEGLHGFHVHEFGDNTAGATSAGPHFNPLSRKHGGPKDEERHVGDLGNVTADKDGVADVSIEDSVISLSGDHCIIGRTLVVHEKADDLGKGGNEESTKTGNAGSRLAAGVIGIAQ
91n18A 0.99 0.98 0.99 3.58Download -ATKAVAVLKGDGPVQGIINFEQKESNGPVKVWGSIKGLTEGLHGFHVHEFGDNTAGCTSAGPHFNPLSRKHGGPKDEERHVGDLGNVTADKDGVADVSIEDSVISLSGDHSIIGRTLVVHEKADDLGKGGNEESTKTGNAGSRLACGVIGIAQ
107rycC 0.14 0.24 0.90 0.67Download TGDVMSLSLAPDTRVSGSAKLWDVREGMC---RQTFTGHESDINAICFFPNGNASDDATC--RLFDLADQELMTYSHDN-IICGITSVSFSKSGRL-------LLAGYDDFNC---NVWDALKADGVLAGHDNRVSCLGVTGMAVATGSWDSFL
(a)All the residues are colored in black; however, those residues in template which are identical to the residue in the query sequence are highlighted in color. Coloring scheme is based on the property of amino acids, where polar are brightly coloured while non-polar residues are colored in dark shade. (more about the colors used)
(b)Rank of templates represents the top ten threading templates used by I-TASSER.
(c)Ident1 is the percentage sequence identity of the templates in the threading aligned region with the query sequence.
(d)Ident2 is the percentage sequence identity of the whole template chains with query sequence.
(e)Cov represents the coverage of the threading alignment and is equal to the number of aligned residues divided by the length of query protein.
(f)Norm. Z-score is the normalized Z-score of the threading alignments. Alignment with a Normalized Z-score >1 mean a good alignment and vice versa.
(g)Download Align. provides the 3D structure of the aligned regions of the threading templates.
(h)The top 10 alignments reported above (in order of their ranking) are from the following threading programs:
       1: FFAS-3D   2: SPARKS-X   3: HHSEARCH2   4: pGenTHREADER   5: wdPPAS   6: PROSPECT2   7: SP3   8: FFAS03   9: FFAS-3D   10: SPARKS-X   

   Top 5 final models predicted by I-TASSER

(For each target, I-TASSER simulations generate a large ensemble of structural conformations, called decoys. To select the final models, I-TASSER uses the SPICKER program to cluster all the decoys based on the pair-wise structure similarity, and reports up to five models which corresponds to the five largest structure clusters. The confidence of each model is quantitatively measured by C-score that is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [-5, 2], where a C-score of a higher value signifies a model with a higher confidence and vice-versa. TM-score and RMSD are estimated based on C-score and protein length following the correlation observed between these qualities. Since the top 5 models are ranked by the cluster size, it is possible that the lower-rank models have a higher C-score in rare cases. Although the first model has a better quality in most cases, it is also possible that the lower-rank models have a better quality than the higher-rank models as seen in our benchmark tests. If the I-TASSER simulations converge, it is possible to have less than 5 clusters generated; this is usually an indication that the models have a good quality because of the converged simulations.)
    (By right-click on the images, you can export image file or change the configurations, e.g. modifying the background color or stopping the spin of your models)
  • Download Model 1
  • C-score=1.21 (Read more about C-score)
  • Estimated TM-score = 0.88±0.07
  • Estimated RMSD = 2.5±1.9Å

  • Download Model 2
  • C-score = -2.81

  • Download Model 3
  • C-score = -3.22

  • Download Model 4
  • C-score = -4.52

  • Download Model 5
  • C-score = -4.04


  Proteins structurally close to the target in the PDB (as identified by TM-align)

(After the structure assembly simulation, I-TASSER uses the TM-align structural alignment program to match the first I-TASSER model to all structures in the PDB library. This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e. the highest TM-score, to the predicted I-TASSER model. Due to the structural similarity, these proteins often have similar function to the target. However, users are encouraged to use the data in the next section 'Predicted function using COACH' to infer the function of the target protein, since COACH has been extensively trained to derive biological functions from multi-source of sequence and structure features which has on average a higher accuracy than the function annotations derived only from the global structure comparison.)


Top 10 Identified stuctural analogs in PDB

Click
to view
RankPDB HitTM-scoreRMSDaIDENaCovAlignment
16foiA0.988 0.360.9870.994Download
23gttA0.985 0.450.8370.994Download
36dtkA0.983 0.990.9811.000Download
46zs1A0.980 0.690.5521.000Download
55in2A0.976 0.690.5820.994Download
61to4A0.976 0.860.5841.000Download
73kbfA0.971 0.610.5720.987Download
82jcwA0.968 0.660.5530.987Download
91srdA0.966 0.820.5620.994Download
101cb4A0.965 0.740.8150.981Download

(a)Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)RMSDa is the RMSD between residues that are structurally aligned by TM-align.
(d)IDENa is the percentage sequence identity in the structurally aligned region.
(e)Cov represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.


  Predicted function using COFACTOR and COACH

(This section reports biological annotations of the target protein by COFACTOR and COACH based on the I-TASSER structure prediction. While COFACTOR deduces protein functions (ligand-binding sites, EC and GO) using structure comparison and protein-protein networks, COACH is a meta-server approach that combines multiple function annotation results (on ligand-binding sites) from the COFACTOR, TM-SITE and S-SITE programs.)

  Ligand binding sites


Click
to view
RankC-scoreCluster
size
PDB
Hit
Lig
Name
Download
Complex
Ligand Binding Site Residues
10.86 91 1to4A CU Rep, Mult 47,49,64,121
20.35 56 1do5A ZN Rep, Mult 64,72,81,84
30.09 14 2wz5F MET Rep, Mult 31,32,33,99,100,101
40.04 6 4a7gA 12I Rep, Mult 26,27,28,103,104,106,108,110,111
50.03 5 4b3eF CO3 Rep, Mult 121,142,144


Download the residue-specific ligand binding probability, which is estimated by SVM.
Download the all possible binding ligands and detailed prediction summary.
Download the templates clustering results.
(a)C-score is the confidence score of the prediction. C-score ranges [0-1], where a higher score indicates a more reliable prediction.
(b)Cluster size is the total number of templates in a cluster.
(c)Lig Name is name of possible binding ligand. Click the name to view its information in the BioLiP database.
(d)Rep is a single complex structure with the most representative ligand in the cluster, i.e., the one listed in the Lig Name column.
Mult is the complex structures with all potential binding ligands in the cluster.

  Enzyme Commission (EC) numbers and active sites


Click
to view
RankCscoreECPDB
Hit
TM-scoreRMSDaIDENaCovEC NumberActive Site Residues
10.7791azvA0.988 0.340.9930.994 1.15.1.1  64,144
20.7781oztG0.835 0.510.9850.844 1.15.1.1  64,144
30.7771cb4A0.965 0.740.8150.981 1.15.1.1  64,144
40.7751srdA0.966 0.820.5620.994 1.15.1.1  64,144
50.7693f7kA0.960 0.770.6160.981 1.15.1.1  64,144

 Click on the radio buttons to visualize predicted active site residues.
(a)CscoreEC is the confidence score for the EC number prediction. CscoreEC values range in between [0-1];
where a higher score indicates a more reliable EC number prediction.
(b)TM-score is a measure of global structural similarity between query and template protein.
(c)RMSDa is the RMSD between residues that are structurally aligned by TM-align.
(d)IDENa is the percentage sequence identity in the structurally aligned region.
(e)Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided
by length of the query protein.

  Gene Ontology (GO) terms
Top 10 homologous GO templates in PDB 
RankCscoreGOTM-scoreRMSDaIDENaCovPDB HitAssociated GO Terms
1 0.800.7596 0.44 0.99 0.772zkxD GO:0007283 GO:0007568 GO:0005730 GO:0031667 GO:0032287 GO:0005507 GO:0006979 GO:0000303 GO:0005829 GO:0005515 GO:0005634 GO:0001895 GO:0001819 GO:0032839 GO:0043025 GO:0009408 GO:0019226 GO:0010033 GO:0060087 GO:0005739 GO:0043524 GO:0060088 GO:0031410 GO:0008219 GO:0001975 GO:0050665 GO:0006749 GO:0007626 GO:0042493 GO:0048678 GO:0001890 GO:0006309 GO:0031012 GO:0007605 GO:0046716 GO:0060052 GO:0005759 GO:0006302 GO:0019430 GO:0002576 GO:0043066 GO:0001541 GO:0006879 GO:0007569 GO:0048538 GO:0045541 GO:0045471 GO:0042554 GO:0042542 GO:0002262 GO:0006801 GO:0033081 GO:0008217 GO:0006916 GO:0004784 GO:0005615 GO:0051881 GO:0045859 GO:0042803 GO:0016491 GO:0046872 GO:0055114 GO:0030168 GO:0030346 GO:0043234 GO:0007596 GO:0005576 GO:0007566 GO:0005886 GO:0046688 GO:0051087 GO:0005737 GO:0043065 GO:0060047 GO:0008270 GO:0043085 GO:0016209 GO:0000302 GO:0005777 GO:0046620 GO:0000187 GO:0040014
2 0.790.9883 0.34 0.99 0.991azvA GO:0043025 GO:0042554 GO:0042542 GO:0002262 GO:0046620 GO:0000187 GO:0040014 GO:0045859 GO:0042803 GO:0016491 GO:0046872 GO:0055114 GO:0030168 GO:0046688 GO:0051087 GO:0005737 GO:0043065 GO:0001541 GO:0000303 GO:0005829 GO:0007283 GO:0009408 GO:0019226 GO:0010033 GO:0060087 GO:0005739 GO:0016209 GO:0000302 GO:0005777 GO:0006916 GO:0004784 GO:0005615 GO:0051881 GO:0050665 GO:0006749 GO:0007626 GO:0042493 GO:0048678 GO:0001890 GO:0030346 GO:0008270 GO:0043085 GO:0019430 GO:0002576 GO:0043066 GO:0005515 GO:0005634 GO:0001895 GO:0001819 GO:0032839 GO:0043234 GO:0007596 GO:0005576 GO:0007566 GO:0005886 GO:0006302 GO:0006801 GO:0033081 GO:0008217 GO:0043524 GO:0060088 GO:0031410 GO:0008219 GO:0001975 GO:0007568 GO:0005730 GO:0031667 GO:0032287 GO:0005507 GO:0006309 GO:0031012 GO:0007605 GO:0006879 GO:0007569 GO:0048538 GO:0045541 GO:0045471 GO:0060047 GO:0046716 GO:0060052 GO:0005759 GO:0006979
3 0.780.8699 0.41 0.99 0.883cqqA GO:0055114 GO:0050665 GO:0001541 GO:0006879 GO:0007569 GO:0048538 GO:0045541 GO:0005515 GO:0045471 GO:0060047 GO:0046620 GO:0000187 GO:0040014 GO:0045859 GO:0042803 GO:0016491 GO:0046872 GO:0005777 GO:0006916 GO:0004784 GO:0005615 GO:0051881 GO:0006801 GO:0006749 GO:0007626 GO:0042493 GO:0048678 GO:0001890 GO:0030346 GO:0030168 GO:0046688 GO:0051087 GO:0005737 GO:0043065 GO:0005886 GO:0006302 GO:0019430 GO:0002576 GO:0043066 GO:0005730 GO:0005634 GO:0001895 GO:0001819 GO:0032839 GO:0043025 GO:0042554 GO:0008270 GO:0043085 GO:0016209 GO:0000302 GO:0000303 GO:0042542 GO:0002262 GO:0009408 GO:0019226 GO:0010033 GO:0033081 GO:0008217 GO:0043524 GO:0060088 GO:0031410 GO:0008219 GO:0043234 GO:0007596 GO:0005576 GO:0007566 GO:0060087 GO:0005739 GO:0001975 GO:0007568 GO:0005829 GO:0007283 GO:0031667 GO:0032287 GO:0005507 GO:0006309 GO:0031012 GO:0007605 GO:0046716 GO:0060052 GO:0005759 GO:0006979
4 0.770.9632 0.79 0.63 0.993l9eA GO:0016491 GO:0046872 GO:0016209 GO:0055114 GO:0005737 GO:0004784 GO:0006801
5 0.770.9845 0.45 0.84 0.993gttA GO:0043025 GO:0009408 GO:0060047 GO:0060088 GO:0005515 GO:0051881 GO:0007283 GO:0006979 GO:0008270 GO:0043085 GO:0046716 GO:0043524 GO:0005634 GO:0000302 GO:0005886 GO:0031667 GO:0006749 GO:0055114 GO:0040014 GO:0031410 GO:0006879 GO:0001895 GO:0032839 GO:0001541 GO:0019226 GO:0042493 GO:0043066 GO:0005829 GO:0005737 GO:0004784 GO:0019430 GO:0060087 GO:0042554 GO:0000303 GO:0001975 GO:0016209 GO:0006302 GO:0006801 GO:0005615 GO:0060052 GO:0001819 GO:0008217 GO:0007568 GO:0050665 GO:0010033 GO:0030346 GO:0006309 GO:0002262 GO:0048678 GO:0031012 GO:0000187 GO:0007569 GO:0043234 GO:0007626 GO:0045859 GO:0007605 GO:0006916 GO:0005507 GO:0032287 GO:0042542 GO:0045541 GO:0046688 GO:0005739 GO:0051087 GO:0016491 GO:0046872 GO:0007566 GO:0045471 GO:0043065 GO:0046620 GO:0048538 GO:0030168 GO:0033081 GO:0005759 GO:0008219 GO:0005730 GO:0002576 GO:0005777 GO:0001890 GO:0007596 GO:0005576 GO:0042803
6 0.760.9522 0.73 0.49 0.971do5A GO:0006801 GO:0046872 GO:0055114
7 0.760.9653 0.74 0.81 0.981cb4A GO:0043025 GO:0004784 GO:0019430 GO:0042542 GO:0005576 GO:0005886 GO:0010033 GO:0045541 GO:0016491 GO:0043161 GO:0005737 GO:0001541 GO:0009408 GO:0045471 GO:0005507 GO:0006979 GO:0051087 GO:0004842 GO:0006749 GO:0044419 GO:0007283 GO:0005615 GO:0032287 GO:0043524 GO:0060087 GO:0016209 GO:0046872 GO:0007605 GO:0042493 GO:0048678 GO:0043234 GO:0006302 GO:0006309 GO:0006879 GO:0008217 GO:0001895 GO:0060047 GO:0046716 GO:0055114 GO:0045859 GO:0060088 GO:0043085 GO:0030346 GO:0019226 GO:0032839 GO:0051770 GO:0006801 GO:0001817 GO:0051881 GO:0002262 GO:0007566 GO:0060052 GO:0031012 GO:0000209 GO:0008270 GO:0000187 GO:0007626 GO:0040014 GO:0050665 GO:0000303 GO:0001819 GO:0005634 GO:0005739 GO:0005829 GO:0007569 GO:0031410
8 0.760.9625 0.52 0.68 0.971xsoA GO:0005737 GO:0004784 GO:0016491 GO:0016209 GO:0055114 GO:0046872 GO:0006801
9 0.760.9662 0.82 0.56 0.991srdA GO:0006801 GO:0046872 GO:0055114 GO:0004784 GO:0016209 GO:0009507 GO:0016491 GO:0009536
10 0.750.9755 0.86 0.58 1.001to4A GO:0055114 GO:0016491 GO:0016209 GO:0004784 GO:0005737 GO:0046872 GO:0006801


Consensus prediction of GO terms
 
Molecular Function GO:0004784 GO:0042803 GO:0030346 GO:0008270 GO:0005507 GO:0051087
GO-Score 1.00 1.00 1.00 1.00 1.00 1.00
Biological Process GO:0055114 GO:0001895 GO:0060047 GO:0007283 GO:0030168 GO:0006302 GO:0000187 GO:0045471 GO:0033081 GO:0001890
GO-Score 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00
Cellular Component GO:0005777 GO:0005615 GO:0032839 GO:0005829 GO:0005759 GO:0031410 GO:0005886 GO:0031012 GO:0043234 GO:0043025
GO-Score 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00

(a)CscoreGO is a combined measure for evaluating global and local similarity between query and template protein. It's range is [0-1] and higher values indicate more confident predictions.
(b)TM-score is a measure of global structural similarity between query and template protein.
(c)RMSDa is the RMSD between residues that are structurally aligned by TM-align.
(d)IDENa is the percentage sequence identity in the structurally aligned region.
(e)Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.
(f)The second table shows a consensus GO terms amongst the top scoring templates. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on CscoreGO of the template.


[Click on S692909_results.tar.bz2 to download the tarball file including all modeling results listed on this page]



Please cite the following articles when you use the I-TASSER server:
  • Wei Zheng, Chengxin Zhang, Yang Li, Robin Pearce, Eric W. Bell, Yang Zhang. Folding non-homology proteins by coupling deep-learning contact maps with I-TASSER assembly simulations. Cell Reports Methods, 1: 100014 (2021).
  • Chengxin Zhang, Peter L. Freddolino, and Yang Zhang. COFACTOR: improved protein function prediction by combining structure, sequence and protein-protein interaction information. Nucleic Acids Research, 45: W291-299 (2017).
  • Jianyi Yang, Yang Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015.