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I-TASSER results for job id S693345

(Click on S693345_results.tar.bz2 to download the tarball file including all modeling results listed on this page. Click on Annotation of I-TASSER Output to read the instructions for how to interpret the results on this page. Model results are kept on the server for 60 days, there is no way to retrieve the modeling data older than 2 months)

  Submitted Sequence in FASTA format

>protein
MNIDQHHQLQQQHQQQMLQQQAQAQAQAQAQAQQQQQQQQQAAAAAAAANAAATTSSSPR
QVSFNVSDHYQILEIVGEGAYGIVCSAIHKPSQQKVAIKKIEPFERSMLCLRTLRELKLL
KHFNHENIISILAIQRPINYESFNEIYLIQELMETDLHRVIRTQNLSDDHIQYFIYQTLR
ALKAMHSANVLHRDLKPSNLLLNSNCDLKICDFGLARSIASQEDNYGFMTEYVATRWYRA
PEIMLTFQEYTTAIDVWSVGCILAEMLSGRPLFPGRDYHNQLWLIMEVLGTPNMEDYYNI
KSKRAREYIRSLPFCKKIPFSELFANTNNNTSTSTSNTGGRTNINPLALDLLEKLLIFNP
AKRITVEDALKHPYLQLYHDPNDEPISDKIPEDFFDFDKMKDQLTIEDLKKLLYEEIMKP
L

  Predicted Secondary Structure

Sequence                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280                 300                 320                 340                 360                 380                 400                 420
                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   | 
MNIDQHHQLQQQHQQQMLQQQAQAQAQAQAQAQQQQQQQQQAAAAAAAANAAATTSSSPRQVSFNVSDHYQILEIVGEGAYGIVCSAIHKPSQQKVAIKKIEPFERSMLCLRTLRELKLLKHFNHENIISILAIQRPINYESFNEIYLIQELMETDLHRVIRTQNLSDDHIQYFIYQTLRALKAMHSANVLHRDLKPSNLLLNSNCDLKICDFGLARSIASQEDNYGFMTEYVATRWYRAPEIMLTFQEYTTAIDVWSVGCILAEMLSGRPLFPGRDYHNQLWLIMEVLGTPNMEDYYNIKSKRAREYIRSLPFCKKIPFSELFANTNNNTSTSTSNTGGRTNINPLALDLLEKLLIFNPAKRITVEDALKHPYLQLYHDPNDEPISDKIPEDFFDFDKMKDQLTIEDLKKLLYEEIMKPL
PredictionCCCCCHHHHHCCCCHHHCCCCCCCCCCCCCCCCHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCSSSSSSSSCCCCSSSSSSSSCCCCCSSSSSSSCCCCCCCCHHHHHHHHHHHHHCCCCCCCCSSSSSCCCCCCCCCSSSSSSSCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCSSCCCCCHHHSSSCCCCCSSSCCCCCCCCCCCCCCCCCCCCCCSSSCCCCCHHHHCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCCCHHHHHHCCCHHHHHHHHHCCCCCCCCHHHHCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCHHHHHCCHHHHCCCCCCCCCCCCCCCCCCCCCCHHCCCCCHHHHHHHHHHHHHHCC
Conf.Score9865313442023412204333455554445420002444456788777777754546677666556764682265137886999999999999889976457666661338999999997789989995677414787677884899985813429999855998999999999999999998871884688888899478899998879875563678887777888886741546888997599766969999998999999971998889898689999999853998988971242677899998678999999799786864121211000013456987999999977430953246899985593330358985466678889887672000144999999999999996059
H:Helix; S:Strand; C:Coil

  Predicted Solvent Accessibility

Sequence                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280                 300                 320                 340                 360                 380                 400                 420
                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   | 
MNIDQHHQLQQQHQQQMLQQQAQAQAQAQAQAQQQQQQQQQAAAAAAAANAAATTSSSPRQVSFNVSDHYQILEIVGEGAYGIVCSAIHKPSQQKVAIKKIEPFERSMLCLRTLRELKLLKHFNHENIISILAIQRPINYESFNEIYLIQELMETDLHRVIRTQNLSDDHIQYFIYQTLRALKAMHSANVLHRDLKPSNLLLNSNCDLKICDFGLARSIASQEDNYGFMTEYVATRWYRAPEIMLTFQEYTTAIDVWSVGCILAEMLSGRPLFPGRDYHNQLWLIMEVLGTPNMEDYYNIKSKRAREYIRSLPFCKKIPFSELFANTNNNTSTSTSNTGGRTNINPLALDLLEKLLIFNPAKRITVEDALKHPYLQLYHDPNDEPISDKIPEDFFDFDKMKDQLTIEDLKKLLYEEIMKPL
Prediction7435433414453555444554645544444444446445634454444544433334145140403730431330031000000002136364300001030163332020000001003306060001011003064274031000001001100210044360354001000000010010000020000001010000134040000000000221456643220010000000000000000351230000000000000114331002141102003100510120446005303173024004503734634044101303343333333333344321200100320041117311304300312003501337313416433533031433466132630240004002535
Values range from 0 (buried residue) to 9 (highly exposed residue)

   Predicted normalized B-factor

(B-factor is a value to indicate the extent of the inherent thermal mobility of residues/atoms in proteins. In I-TASSER, this value is deduced from threading template proteins from the PDB in combination with the sequence profiles derived from sequence databases. The reported B-factor profile in the figure below corresponds to the normalized B-factor of the target protein, defined by B=(B'-u)/s, where B' is the raw B-factor value, u and s are respectively the mean and standard deviation of the raw B-factors along the sequence. Click here to read more about predicted normalized B-factor)


  Top 10 threading templates used by I-TASSER

(I-TASSER modeling starts from the structure templates identified by LOMETS from the PDB library. LOMETS is a meta-server threading approach containing multiple threading programs, where each threading program can generate tens of thousands of template alignments. I-TASSER only uses the templates of the highest significance in the threading alignments, the significance of which are measured by the Z-score, i.e. the difference between the raw and average scores in the unit of standard deviation. The templates in this section are the 10 best templates selected from the LOMETS threading programs. Usually, one template of the highest Z-score is selected from each threading program, where the threading programs are sorted by the average performance in the large-scale benchmark test experiments.)

Rank PDB
Hit
Iden1Iden2CovNorm.
Z-score
Download
Align.
                   20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280                 300                 320                 340                 360                 380                 400                 420
                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   | 
Sec.Str
Seq
CCCCCHHHHHCCCCHHHCCCCCCCCCCCCCCCCHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCSSSSSSSSCCCCSSSSSSSSCCCCCSSSSSSSCCCCCCCCHHHHHHHHHHHHHCCCCCCCCSSSSSCCCCCCCCCSSSSSSSCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCSSCCCCCHHHSSSCCCCCSSSCCCCCCCCCCCCCCCCCCCCCCSSSCCCCCHHHHCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCCCHHHHHHCCCHHHHHHHHHCCCCCCCCHHHHCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCHHHHHCCHHHHCCCCCCCCCCCCCCCCCCCCCCHHCCCCCHHHHHHHHHHHHHHCC
MNIDQHHQLQQQHQQQMLQQQAQAQAQAQAQAQQQQQQQQQAAAAAAAANAAATTSSSPRQVSFNVSDHYQILEIVGEGAYGIVCSAIHKPSQQKVAIKKIEPFERSMLCLRTLRELKLLKHFNHENIISILAIQRPINYESFNEIYLIQELMETDLHRVIRTQNLSDDHIQYFIYQTLRALKAMHSANVLHRDLKPSNLLLNSNCDLKICDFGLARSIASQEDNYGFMTEYVATRWYRAPEIMLTFQEYTTAIDVWSVGCILAEMLSGRPLFPGRDYHNQLWLIMEVLGTPNMEDYYNIKSKRAREYIRSLPFCKKIPFSELFANTNNNTSTSTSNTGGRTNINPLALDLLEKLLIFNPAKRITVEDALKHPYLQLYHDPNDEPISDKIPEDFFDFDKMKDQLTIEDLKKLLYEEIMKPL
12zoqA 0.53 0.44 0.82 4.95Download ---------------------------------------------------VPGEVEMVKGQPFDVGPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRFRHENVIGIRDILRASTLEAMRDVYIVQDLMETDLYKLLKSQQLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTE-VATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINMKARNYLQSLPSKTKVAWAKLFPKS-----------------DSKALDLLDRMLTFNPNKRITVEEALAHPYLEQYYDPTDEPVAEE----PFTFAMELDDLPKERLKELIFQETARF-
27e73A 0.56 0.47 0.82 2.74Download -------------------------------------------------------PEMVRGQVFDVGPRYTNLSYIGEGAHGMVCSAYDNVNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNA-----------------DSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAE----APFKFDMELDDLPKEKLKELIFEETARFQ
35z33 0.53 0.46 0.82 0.66Download ---------------------------------------------------QGRKIFKVFNQDFIVDERYTVTKELGQGAYGIVCAAVNNQTSEGVAIKKVTNVFKKILAKRALREIKLLQHFRHRNITCLYDMDIPR-PDNFNETYLYEELMECDLAAIIRSQPLTDAHFQSFIYQILCGLKYIHSANVLHRDLKPGNLLVNADCELKICDFGLARGFSVDPENAGYMTEYVATRWYRAPEIMLSFQSYTKAIDVWSVGCILAELLGGRPFFKGRDYVDQLNQILHILGTPNEETLSRIGSPRAQEYVRNLPFMAKKPFPTLF-----------------PNANPDALDLLDRMLAFDPSSRISVEQALEHPYLHIWHDASDEPDCPT----TFNFDFEV-VEDVGEMRKMILDEVYRFR
45z33 0.53 0.46 0.82 0.68Download ---------------------------------------------------QGRKIFKVFNQDFIVDERYTVTKELGQGAYGIVCAAVNNQTSEGVAIKKVNVFSKKILAKRALREIKLLQHFRHRNITCLYDMDIPR-PDNFNETYLYEELMECDLAAIIRSQPLTDAHFQSFIYQILCGLKYIHSANVLHRDLKPGNLLVNADCELKICDFGLARGFSVDPENAGYMTEYVATRWYRAPEIMLSFQSYTKAIDVWSVGCILAELLGGRPFFKGRDYVDQLNQILHILGTPNEETLSRIGSPRAQEYVRNLPFMAKKPFPTLFPNA-----------------NPDALDLLDRMLAFDPSSRISVEQALEHPYLHIWHDASDEPDCPT----TFNFDFEVV-EDVGEMRKMILDEVYRFR
54o2zA 0.38 0.34 0.85 3.24Download -----------------------------------NLYFQGNQELSVPKIVGDFKVYNVSGSPFEVPSKYTLLKILGMGAYGIACSCLDGDTGEKVSIKKCDVFRDVEDGKRVLREIDMMRFFHHENLLNVVNILPPREYHSFEDVYVVTPLMDVDMNVVLRSQVLEESHMQYFVYQILRGLKYLHSANVAHRDLKPANLVTNISCELKIIDFGLSR-----SVPYSELTDYVITRWYRPPELLLENTNYSTAVDIWSVGCIFAEMYNRKPVFPGRNTMDQLRMIAQHIGKPPASI---VEHREALEKLNELPDG-SLNIPKLVPGLAG---------------NTEGIDFLSKMWTLDPSKRPTAADMLAHPYLAHLHDEEDEPTCPC----PFLWAHESTPMGVSELRRAFWADIVDYN
65z33 0.55 0.46 0.79 0.76Download ---------------------------------------------------------------FIVDERYTVTKELGQGAYGIVCAAVNNQTSEGVAIKKVTNVSKKILAKRALREIKLLQHFRHRNITCLYDMDIPR-PDNFNETYLYEELMECDLAAIIRSGPLTDAHFQSFIYQILCGLKYIHSANVLHRDLKPGNLLVNADCELKICDFGLARGFSVDPENAGYMTEYVATRWYRAPEIMLSFQSYTKAIDVWSVGCILAELLGGRPFFKGRDYVDQLNQILHILGTPNEETLSRIGSPRAQEYVRNLPFMAKKPFPTLF-----------------PNANPDALDLLDRMLAFDPSSRISVEQALEHPYLHIWHDASDEPDCPT----TFNFDFE-VVEDVGEMRKMILDEVYR--
75byzA 0.51 0.42 0.80 9.76Download --------------------------------------------------------------TFDVGDEYEIIETIGNGAYGVVSSARRRLTGQQVAIKKINAFDVVTNAKRTLRELKILKHFKHDNIIAIKDILRPTPYGEFKSVYVVLDLMESDLHQIIHSQPLTLEHVRYFLYQLLRGLKYMHSAQVIHRDLKPSNLLVNENCELKIGDFGMARGLCTPAEHQYFMTEYVATRWYRAPELMLSLHEYTQAIDLWSVGCIFGEMLARRQLFPGKNYVHQLQLIMMVLGTPSPAVIQAVGAERVRAYIQSLPPRQPVPWETVYPGA-----------------DRQALSLLGRMLRFEPSARISAAAALRHPFLAKYHDPDDEPDCAPP----FDFAFDREALTRERIKEAIVAEIEDFH
84o2zA 0.38 0.34 0.85 2.83Download -----------------------------------NLYFQGNQELSVPKIVGDFKVYNVSGSPFEVPSKYTLLKILGMGAYGIACSCLDGDTGEKVSIKKCDVFRDVEDGKRVLREIDMMRFFHHENLLNVVNILPPLEYHSFEDVYVVTPLMDVDMNVVLRSQVLEESHMQYFVYQILRGLKYLHSANVAHRDLKPANLVTNISCELKIIDFGLSRSVPYSE-----LTDYVITRWYRPPELLLENTNYSTAVDIWSVGCIFAEMYNRKPVFPGRNTMDQLRMIAQHIGKPPASI---VEHREALEKLNELPD-GSLNIPKLVPG---------------LAGNTEGIDFLSKMWTLDPSKRPTAADMLAHPYLAHLHDEEDEPTCPCP----FLWAHESTPMGVSELRRAFWADIVDYN
97e73A 0.57 0.47 0.82 3.92Download -------------------------------------------------------PEMVRGQVFDVGPRYTNLSYIGEGAHGMVCSAYDNVNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNA-----------------DSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEA----PFKFDMELDDLPKEKLKELIFEETARPG
105z33A 0.53 0.46 0.82 3.18Download ---------------------------------------------------QGRKIFKVFNQDFIVDERYTVTKELGQGAYGIVCAAVNNQTSEGVAIKKVNVFSKKILAKRALREIKLLQHFGHRNITCLYDMDIPR-PDNFNETYLYEELMECDLAAIIRSQPLTDAHFQSFIYQILCGLKYIHSANVLHRDLKPGNLLVNADCELKICDFGLARGFSVDPENAGYMTEYVATRWYRAPEIMLSFQSYTKAIDVWSVGCILAELLGGRPFFKGRDYVDQLNQILHILGTPNEETLSRIGSPRAQEYVRNLPFMAKKPFPTLFPNA-----------------NPDALDLLDRMLAFDPSSRISVEQALEHPYLHIWHDASDEPDCPT----TFNFDFEVVE-DVGEMRKMILDEVYRFR
(a)All the residues are colored in black; however, those residues in template which are identical to the residue in the query sequence are highlighted in color. Coloring scheme is based on the property of amino acids, where polar are brightly coloured while non-polar residues are colored in dark shade. (more about the colors used)
(b)Rank of templates represents the top ten threading templates used by I-TASSER.
(c)Ident1 is the percentage sequence identity of the templates in the threading aligned region with the query sequence.
(d)Ident2 is the percentage sequence identity of the whole template chains with query sequence.
(e)Cov represents the coverage of the threading alignment and is equal to the number of aligned residues divided by the length of query protein.
(f)Norm. Z-score is the normalized Z-score of the threading alignments. Alignment with a Normalized Z-score >1 mean a good alignment and vice versa.
(g)Download Align. provides the 3D structure of the aligned regions of the threading templates.
(h)The top 10 alignments reported above (in order of their ranking) are from the following threading programs:
       1: FFAS-3D   2: SPARKS-X   3: HHSEARCH2   4: HHSEARCH I   5: Neff-PPAS   6: HHSEARCH   7: pGenTHREADER   8: wdPPAS   9: PROSPECT2   10: SP3   

   Top 5 final models predicted by I-TASSER

(For each target, I-TASSER simulations generate a large ensemble of structural conformations, called decoys. To select the final models, I-TASSER uses the SPICKER program to cluster all the decoys based on the pair-wise structure similarity, and reports up to five models which corresponds to the five largest structure clusters. The confidence of each model is quantitatively measured by C-score that is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [-5, 2], where a C-score of a higher value signifies a model with a higher confidence and vice-versa. TM-score and RMSD are estimated based on C-score and protein length following the correlation observed between these qualities. Since the top 5 models are ranked by the cluster size, it is possible that the lower-rank models have a higher C-score in rare cases. Although the first model has a better quality in most cases, it is also possible that the lower-rank models have a better quality than the higher-rank models as seen in our benchmark tests. If the I-TASSER simulations converge, it is possible to have less than 5 clusters generated; this is usually an indication that the models have a good quality because of the converged simulations.)
    (By right-click on the images, you can export image file or change the configurations, e.g. modifying the background color or stopping the spin of your models)
  • Download Model 1
  • C-score=-1.20 (Read more about C-score)
  • Estimated TM-score = 0.56±0.15
  • Estimated RMSD = 9.7±4.6Å

  • Download Model 2
  • C-score = -1.32

  • Download Model 3
  • C-score = -2.23

  • Download Model 4
  • C-score = -2.37

  • Download Model 5
  • C-score = -1.52


  Proteins structurally close to the target in the PDB (as identified by TM-align)

(After the structure assembly simulation, I-TASSER uses the TM-align structural alignment program to match the first I-TASSER model to all structures in the PDB library. This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e. the highest TM-score, to the predicted I-TASSER model. Due to the structural similarity, these proteins often have similar function to the target. However, users are encouraged to use the data in the next section 'Predicted function using COACH' to infer the function of the target protein, since COACH has been extensively trained to derive biological functions from multi-source of sequence and structure features which has on average a higher accuracy than the function annotations derived only from the global structure comparison.)


Top 10 Identified stuctural analogs in PDB

Click
to view
RankPDB HitTM-scoreRMSDaIDENaCovAlignment
15z33A0.808 1.200.5270.824Download
21erkA0.795 1.660.5500.824Download
32zoqA0.795 1.700.5230.827Download
42h96A0.775 2.300.3930.834Download
52b9iA0.764 1.670.6120.796Download
64o2zA0.764 2.190.3560.815Download
75ci6A0.747 1.690.4880.779Download
84b99A0.746 1.630.5200.772Download
93npcA0.744 2.460.3750.803Download
101pmuA0.742 2.370.4070.800Download

(a)Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)RMSDa is the RMSD between residues that are structurally aligned by TM-align.
(d)IDENa is the percentage sequence identity in the structurally aligned region.
(e)Cov represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.


  Predicted function using COFACTOR and COACH

(This section reports biological annotations of the target protein by COFACTOR and COACH based on the I-TASSER structure prediction. While COFACTOR deduces protein functions (ligand-binding sites, EC and GO) using structure comparison and protein-protein networks, COACH is a meta-server approach that combines multiple function annotation results (on ligand-binding sites) from the COFACTOR, TM-SITE and S-SITE programs.)

  Ligand binding sites


Click
to view
RankC-scoreCluster
size
PDB
Hit
Lig
Name
Download
Complex
Ligand Binding Site Residues
10.89 1855 5e8yA STU Rep, Mult 76,77,78,84,97,99,129,150,151,152,153,154,155,156,198,199,201,211,212
20.10 164 3mvmA 39P Rep, Mult 76,84,97,99,116,119,120,129,148,150,151,152,153,155,211,212,213,215
30.04 59 2y9qA PEPTIDE Rep, Mult 126,154,155,160,164,166,169,170,173,176,177,180,203,204,205,206,207,378,380,383
40.03 49 4ux9C PEPTIDE Rep, Mult 154,155,159,164,166,169,170,173,202,203,204,205,206,377,378
50.03 72 4z83E PEPTIDE Rep, Mult 108,156,158,159,162,196,197,198,215,230,233,234,235,236,237,238,239,265,269,270,271,274,276,281,282


Download the residue-specific ligand binding probability, which is estimated by SVM.
Download the all possible binding ligands and detailed prediction summary.
Download the templates clustering results.
(a)C-score is the confidence score of the prediction. C-score ranges [0-1], where a higher score indicates a more reliable prediction.
(b)Cluster size is the total number of templates in a cluster.
(c)Lig Name is name of possible binding ligand. Click the name to view its information in the BioLiP database.
(d)Rep is a single complex structure with the most representative ligand in the cluster, i.e., the one listed in the Lig Name column.
Mult is the complex structures with all potential binding ligands in the cluster.

  Enzyme Commission (EC) numbers and active sites


Click
to view
RankCscoreECPDB
Hit
TM-scoreRMSDaIDENaCovEC NumberActive Site Residues
10.2972b9iA0.764 1.670.6120.796 2.7.11.24 2.7.1.37  NA
20.2942zoqA0.795 1.700.5230.827 2.7.11.24  NA
30.2881erkA0.795 1.660.5500.824 2.7.11.24 2.7.1.-  NA
40.2871unlA0.642 2.100.3610.684 2.7.11.22  NA
50.2872ewaA0.732 1.700.4770.765 2.7.11.24 2.7.1.37  NA

 Click on the radio buttons to visualize predicted active site residues.
(a)CscoreEC is the confidence score for the EC number prediction. CscoreEC values range in between [0-1];
where a higher score indicates a more reliable EC number prediction.
(b)TM-score is a measure of global structural similarity between query and template protein.
(c)RMSDa is the RMSD between residues that are structurally aligned by TM-align.
(d)IDENa is the percentage sequence identity in the structurally aligned region.
(e)Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided
by length of the query protein.

  Gene Ontology (GO) terms
Top 10 homologous GO templates in PDB 
RankCscoreGOTM-scoreRMSDaIDENaCovPDB HitAssociated GO Terms
1 0.510.7642 1.67 0.61 0.802b9iA GO:0043332 GO:0010526 GO:0004707 GO:0005524 GO:0051301 GO:0004672 GO:0004674 GO:0016740 GO:0001403 GO:0042597 GO:0000166 GO:0016301 GO:0007067 GO:0016310 GO:0006468 GO:0007050 GO:0000750 GO:0005737 GO:0043409 GO:0016772 GO:0007049 GO:0005634 GO:0000746 GO:0005515 GO:0005739
2 0.510.7952 1.66 0.55 0.821erkA GO:0008134 GO:0005654 GO:0001784 GO:0045596 GO:0000166 GO:0016301 GO:0019233 GO:0033267 GO:0007243 GO:0009636 GO:0008284 GO:0043204 GO:0004672 GO:0008353 GO:0032496 GO:0005524 GO:0042221 GO:0043234 GO:0005634 GO:0004707 GO:0032839 GO:0005515 GO:0007165 GO:0009887 GO:0043330 GO:0045727 GO:0005626 GO:0006974 GO:0019858 GO:0031663 GO:0005737 GO:0007049 GO:0016310 GO:0030335 GO:0045893 GO:0050852 GO:0050853 GO:0060716 GO:0016740 GO:0031435 GO:0005625 GO:0000165 GO:0006468 GO:0000189 GO:0005829 GO:0004674 GO:0043627 GO:0035556 GO:0016772 GO:0051090 GO:0007173 GO:0070371 GO:0045087 GO:0034138 GO:0000187 GO:0048011 GO:0019902 GO:0006351 GO:0007411 GO:0034134 GO:0034130 GO:0000186 GO:0006917 GO:0006950 GO:0006355 GO:0007596 GO:0008063 GO:0002755 GO:0007265 GO:0003677 GO:0044419 GO:0006935 GO:0051403 GO:0002756 GO:0007268 GO:0030168 GO:0007264 GO:0008286 GO:0002224 GO:0034142
3 0.470.7950 1.70 0.52 0.832zoqA GO:0007411 GO:0035066 GO:0031663 GO:0007265 GO:0016740 GO:0048011 GO:0019902 GO:0034134 GO:0002755 GO:0007049 GO:0016310 GO:0044419 GO:0034142 GO:0006468 GO:0001784 GO:0002224 GO:0000165 GO:0019233 GO:0000166 GO:0000187 GO:0034138 GO:0008063 GO:0005737 GO:0000186 GO:0009887 GO:0005515 GO:0004674 GO:0034130 GO:0004707 GO:0070498 GO:0005524 GO:0006360 GO:0007264 GO:0004672 GO:0005634 GO:0045087 GO:0007596 GO:0005654 GO:0007173 GO:0005829 GO:0051216 GO:0051090 GO:0002756 GO:0051403 GO:0006974 GO:0071260 GO:0030168 GO:0043330 GO:0045944 GO:0008286 GO:0006361 GO:0032496 GO:0016301 GO:0033129 GO:0016772
4 0.450.7360 2.46 0.46 0.803itzA GO:0002756 GO:0006950 GO:0006928 GO:0034134 GO:0005524 GO:0004672 GO:0016310 GO:0042692 GO:0045087 GO:0034142 GO:0007165 GO:0000187 GO:0004707 GO:0005515 GO:0048011 GO:0051090 GO:0000166 GO:0005634 GO:0016740 GO:0007243 GO:0005654 GO:0004708 GO:2000379 GO:0071479 GO:0042770 GO:0016070 GO:0004674 GO:0016301 GO:0008063 GO:0034138 GO:0051403 GO:0007596 GO:0016772 GO:0005829 GO:0006935 GO:0002755 GO:0002224 GO:0006468 GO:0007166 GO:0007265 GO:0016071 GO:0030168 GO:0051149 GO:0090400 GO:0005737 GO:0034130 GO:0009749 GO:0006006 GO:0032495 GO:0005625 GO:0046777 GO:0045648 GO:0018105 GO:0002062 GO:0045944 GO:0032496 GO:0000922 GO:0031663 GO:0044445 GO:0005739 GO:0000077 GO:0007519 GO:0000902 GO:0019395 GO:0005623 GO:0001525 GO:0008022
5 0.450.7424 2.37 0.41 0.801pmuA GO:0016301 GO:0005886 GO:0005829 GO:0034142 GO:0002224 GO:0034134 GO:0008063 GO:0016310 GO:0002755 GO:0000166 GO:0034130 GO:0051090 GO:0005515 GO:0007258 GO:0005737 GO:0004707 GO:0004708 GO:0005739 GO:0002756 GO:0016740 GO:0007254 GO:0007165 GO:0005654 GO:0045087 GO:0004674 GO:0034138 GO:0006468 GO:0005524 GO:0004705 GO:0051403 GO:0004672 GO:0016772
6 0.450.6261 2.37 0.39 0.673nizA GO:0016310 GO:0000166 GO:0016301 GO:0005524 GO:0004672 GO:0004674 GO:0006468 GO:0016772
7 0.440.7747 2.30 0.39 0.832h96A GO:0004674 GO:0045087 GO:0006468 GO:0005524 GO:0004705 GO:0005886 GO:0016301 GO:0051403 GO:0005829 GO:0034142 GO:0002224 GO:0034134 GO:0008063 GO:0016310 GO:0002755 GO:0000166 GO:0034130 GO:0051090 GO:0005515 GO:0007258 GO:0005737 GO:0004707 GO:0004708 GO:0005739 GO:0002756 GO:0016740 GO:0007254 GO:0007165 GO:0005654 GO:0034138 GO:0004672 GO:0016772
8 0.440.7256 2.15 0.40 0.771cm8A GO:0004672 GO:0006468 GO:0016772 GO:0005739 GO:0016301 GO:0007265 GO:0007165 GO:0007517 GO:0005515 GO:0000166 GO:0007050 GO:0048011 GO:0000287 GO:0016740 GO:0042692 GO:0004707 GO:0005737 GO:0016310 GO:0007049 GO:0004674 GO:0005625 GO:0045445 GO:0006975 GO:0051149 GO:0005654 GO:0005524 GO:0046872
9 0.420.7343 2.37 0.45 0.793gc8A GO:0051403 GO:0007165 GO:0016301 GO:0004707 GO:0005515 GO:0016071 GO:0007265 GO:0051149 GO:0051090 GO:0002756 GO:0005625 GO:0006468 GO:0016740 GO:0034142 GO:0042692 GO:0006950 GO:0002755 GO:0034138 GO:0007243 GO:0000187 GO:0000166 GO:0048011 GO:0004674 GO:0034130 GO:0016310 GO:0002224 GO:0005654 GO:0016070 GO:0005829 GO:0034134 GO:0005524 GO:0008063 GO:0045087 GO:0004672 GO:0016772
10 0.400.7321 1.70 0.48 0.762ewaA GO:0005829 GO:0016772 GO:0002755 GO:0002224 GO:0006468 GO:0007166 GO:0007265 GO:0016071 GO:0030168 GO:0051149 GO:0090400 GO:0005737 GO:0006950 GO:0002756 GO:0034130 GO:0006928 GO:0034134 GO:0005524 GO:0004672 GO:0016310 GO:0042692 GO:0045087 GO:0034142 GO:0007165 GO:0000187 GO:0004707 GO:0005515 GO:0048011 GO:0051090 GO:0000166 GO:0005634 GO:0016740 GO:0007243 GO:0005654 GO:0004708 GO:2000379 GO:0071479 GO:0042770 GO:0016070 GO:0004674 GO:0016301 GO:0008063 GO:0034138 GO:0051403 GO:0007596 GO:0006935 GO:0006006 GO:0005625 GO:0046777 GO:0045648 GO:0018105 GO:0002062 GO:0045944 GO:0032496 GO:0000922 GO:0031663 GO:0044445 GO:0005739 GO:0000077 GO:0007519 GO:0000902 GO:0019395 GO:0005623 GO:0001525 GO:0009749 GO:0008022 GO:0032495


Consensus prediction of GO terms
 
Molecular Function GO:0005524 GO:0019902 GO:0001784 GO:0004708 GO:0008134 GO:0008353 GO:0003677 GO:0031435 GO:0008022 GO:0004705
GO-Score 0.96 0.74 0.74 0.70 0.51 0.51 0.51 0.51 0.45 0.45
Biological Process GO:0002755 GO:0008063 GO:0002756 GO:0034134 GO:0034142 GO:0051090 GO:0034138 GO:0034130 GO:0051403 GO:0007265
GO-Score 0.92 0.92 0.92 0.92 0.92 0.92 0.92 0.92 0.92 0.86
Cellular Component GO:0005654 GO:0005739 GO:0005625 GO:0043332 GO:0042597 GO:0033267 GO:0005626 GO:0043234 GO:0043204 GO:0032839
GO-Score 0.92 0.85 0.73 0.51 0.51 0.51 0.51 0.51 0.51 0.51

(a)CscoreGO is a combined measure for evaluating global and local similarity between query and template protein. It's range is [0-1] and higher values indicate more confident predictions.
(b)TM-score is a measure of global structural similarity between query and template protein.
(c)RMSDa is the RMSD between residues that are structurally aligned by TM-align.
(d)IDENa is the percentage sequence identity in the structurally aligned region.
(e)Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.
(f)The second table shows a consensus GO terms amongst the top scoring templates. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on CscoreGO of the template.


[Click on S693345_results.tar.bz2 to download the tarball file including all modeling results listed on this page]



Please cite the following articles when you use the I-TASSER server:
  • Wei Zheng, Chengxin Zhang, Yang Li, Robin Pearce, Eric W. Bell, Yang Zhang. Folding non-homology proteins by coupling deep-learning contact maps with I-TASSER assembly simulations. Cell Reports Methods, 1: 100014 (2021).
  • Chengxin Zhang, Peter L. Freddolino, and Yang Zhang. COFACTOR: improved protein function prediction by combining structure, sequence and protein-protein interaction information. Nucleic Acids Research, 45: W291-299 (2017).
  • Jianyi Yang, Yang Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015.