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I-TASSER C-I-TASSER QUARK C-QUARK LOMETS COACH COFACTOR MetaGO MUSTER CEthreader SEGMER FG-MD ModRefiner REMO DEMO SPRING COTH Threpp BSpred ANGLOR EDock BSP-SLIM SAXSTER FUpred ThreaDom ThreaDomEx EvoDesign GPCR-I-TASSER MAGELLAN BindProf BindProfX SSIPe ResQ IonCom STRUM DAMpred

TM-score TM-align US-align MM-align RNA-align NW-align LS-align EDTSurf MVP MVP-Fit SPICKER HAAD PSSpred 3DRobot MR-REX I-TASSER-MR SVMSEQ NeBcon ResPRE TripletRes WDL-RF ATPbind DockRMSD DeepMSA FASPR EM-Refiner

BioLiP E. coli GLASS GPCR-HGmod GPCR-RD GPCR-EXP Tara-3D TM-fold DECOYS POTENTIAL RW/RWplus EvoEF HPSF THE-DB ADDRESS Alpaca-Antibody CASP7 CASP8 CASP9 CASP10 CASP11 CASP12 CASP13 CASP14


LOMETS (Local Meta-Threading Server, version 3) is a next-generation meta-server approach to template-based protein structure prediction and structure-based function annotation. The new program integrates multiple deep learning-based threading methods (CEthreader, DisCovER, EigenThreader, Hybrid-CEthreader, MapAlign) and state-of-the-art profile-based programs (FFAS3D, HHpred, HHsearch, MRFsearch, MUSTER, SparksX). For the first time, LOMETS3 is extended to handling multi-domain proteins by introducing the domain partition (FUpred and ThreaDom) and assembly (DEMO) modules. It also introduces a new module for fast full-length model construction using a gradient-based optimization program (DeepFold), which is guided by restraints from deep-learning (DeepPotential) and LOMETS top templates. Large-scaled benchmark tests showed that the overall template-recognition and full-length model construction accuracy is significantly beyond its predecessors (LOMETS and LOMETS2), due to the integration of deep-learning and multi-domain threading techniques. LOMETS3 participated in CASP14 as 'Zhang-TBM' and was ranked as one of the top methods for automatic protein structure prediction. A detailed description of the LOMETS3 server can be seen on the About LOMETS page. Please post your questions and comments about LOMETS at the Service System Discussion Board.

The output of the LOMETS server includes (Example output):


[Example output]   [About LOMETS]   [Forum]   [Check Previous Jobs]

LOMETS On-line (Example output)



LOMETS Resource:


References:

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