Need help in my protein structure modelling

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Suddoo
Posts: 1
Joined: Thu Dec 02, 2021 9:23 am

Need help in my protein structure modelling

Post by Suddoo »

Hi I-Tasser adviser,

I posted my protein seqeunce since yesterday, the results that I'm obtained especially the C-score is <-1.5 (Eg. -4.5). So I guess that my protein structure model is not realiable. (https://zhanggroup.org/I-TASSER/output/S638613/) IDS638613 for reference.
However I took the protein seqeunce from NCBI CDS seqeunce of Yellow Head Virus (https://www.ncbi.nlm.nih.gov/nuccore/120564522/). The CDS protein sequence provided by NCBI should be very reliable and yet the prediction of I-Tasser for the protein structure is having a very low C-score. It is not acceptable for publication purpose. Please help and give me advice on this. Thank you in advance

From,
Dann
xiaogenz
Posts: 129
Joined: Sun Apr 25, 2021 12:02 am

Re: Need help in my protein structure modelling

Post by xiaogenz »

You can try to use our I-TASSER improved versions, which integrate deep-learning predicted spatial restraints.
C-I-TASSER: https://zhanggroup.org/C-I-TASSER/
I-TASSER-MD: https://zhanggroup.org/I-TASSER-MD/
D-I-TASSER: https://zhanggroup.org/D-I-TASSER/
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