COTH Input Query

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dsairam789
Posts: 4
Joined: Fri Nov 12, 2021 3:42 pm

COTH Input Query

Post by dsairam789 »

Hello,

I used the COTH server for my protein complex and after observing the output, I realized that one of the monomers was in an inaccurate position after the run. So, I was curious if one can upload the PDB structure of a homolog along with the sequence of the protein complex for COTH ? Secondly, is there any alternative co-threading approach wherein this (manual input of a PDB template) can be carried out ?
Yours Sincerely,
Sairam
xiaogenz
Posts: 157
Joined: Sun Apr 25, 2021 12:02 am

Re: COTH Input Query

Post by xiaogenz »

Sorry! The COTH server currently cannot upload templates. You may try to use I-TASSER to build the monomer models, and then input the HDOCK server (http://hdock.phys.hust.edu.cn/) for docking.
dsairam789
Posts: 4
Joined: Fri Nov 12, 2021 3:42 pm

Re: COTH Input Query

Post by dsairam789 »

Thank you for the clarification.

-Sairam
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