BindProf is a method for predicting free energy changes (ΔΔG) of protein-protein binding
interactions upon mutations of residues at the interface. While BindProf adopts a multi-scale
approach using multiple sources of information at different levels of
structural resolution, a unique feature of BindProf
is the inclusion of an interface structural profile score derived from multiple
structure alignments from analogous protein-protein interactions
(>> read more about BindProf ...).
BindProf On-line
NOTE: This server is only for dimeric complexes currently with
mutations at ONE SIDE of the interface,
and both protein chains MUST be indexed from 1.
Downloadable resources
- potential_terms.csv:
scores for each feature for the SKEMPI database of mutations of protein complexes.
- profile_only.csv:
final 10-fold cross-validated model constructed using only the structural profiles and sequence dependent terms.
- cbeta.csv:
model constructed using the structural profiles, sequence dependent terms, and C-Beta terms.
- all_atom.csv:
model constructed with all terms including those requiring a full atom model.
References:
- J R Brender, Y Zhang.
Predicting the Effect of Mutations on Protein-Protein Binding Interactions through Structure-Based Interface Profiles,
PLoS Comput Biol. 2015 Oct 27;11(10):e1004494
[PDF]
[Supplemental Information] .
