C-I-TASSER (Contact-guided Iterative Threading ASSEmbly Refinement) is a
new method extended from
I-TASSER
for high-accuracy protein structure and function predictions.
Starting from a query sequence, C-I-TASSER first generates inter-residue
contact maps using multiple deep neural-network predictors, including
NeBcon, ResPRE, and TripletRes.
It then identifies structural templates from the PDB by multiple threading
approach LOMETS, with full-length atomic models
assembled by contact-map guided replica-exchange Monte Carlo simulations.
Biological functions of the query protein are finally derived from the structure model by
COFACTOR.
The large-scale benchmark tests showed that C-I-TASSER generates significantly
more accurate models than I-TASSER,
especially for the sequences that do not have homologous templates in the PDB.
The output model of C-I-TASSER server is given by both PDB format and ModelCIF format
now.
Please report problems and questions at
our Discussion Board.
yangzhanglabumich.edu
| (734) 647-1549 | 100 Washtenaw Avenue, Ann Arbor, MI 48109-2218