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Structure of PDB 5w4k Chain 1n Binding Site BS01

Receptor Information >5w4k Chain 1n (length=60) Species: 300852 (Thermus thermophilus HB8) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure] ARKALIEKAKRTPKFKVRAYTRCVRCGRARSVYRFFGLCRICLRELAHKG QLPGVRKASW

Ligand information >5w4k Chain 1a (length=1500) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure] uuggagaguuugauccuggcucagggugaacgcuggcggcgugccuaaga caugcaagucgugcgggccgcggguccguggucagcggcggacgggugag uaacgcgugggugaccuacccggaagagggggacaacccggggaaacucg ggcuaaucccccauguggacccgccccuugggguguguccaaagggcuuu gcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaaug gcccaccaaggcgacgacggguagccggucugagaggauggccggccaca ggggcacugagacacgggccccacuccuacgggaggcagcaguuaggaau cuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaagaa gcccuucgggguguaaacuccugaacccgggacgaaacccccgacgaggg gacugacgguaccgggguaauagcgccggccaacuccgugccagcagccg cgguaauacggagggcgcgagcguuacccggauucacugggcguaaaggg cguguaggcggccuggggcgucccaugugaaagaccacggcucaaccgug ggggagcgugggauacgcucaggcuagacggugggagagggugguggaau ucccggaguagcggugaaaugcgcagauaccgggaggaacgccgauggcg aaggcagccaccugguccacccgugacgcugaggcgcgaaagcgugggga gcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcgcu aggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccgcc uggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcccg cacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccuua ccaggccuugacaugcuagggaacccgggugaaagccuggggugccccgc gaggggagcccuagcacaggugcugcauggccgucgucagcucgugccgu gagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguugc cagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggagga aggaggggacgacgucuggucagcauggcccuuacggccugggcgacaca cgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagcua aucgcaaaaaggugggcccaguucggauuggggucugcaacccgacccca ugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaauac guucccgggccuuguacacaccgcccgucacgccaugggagcgggcucua cccgaagucgccgggagccuacgggcaggcgccgaggguagggcccguga cuggggcgaagucguaacaagguagcuguaccggaaggugcggcuggauc .....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<< <.<<<..<<<..<<.<<<<<<<<..>>>>>>>>.>>>>>......<<... ....<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......>>> >>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<<<... >>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<...... .>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.>>. <<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>>>..... ...<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<...... <<<<....>>>>.....>>>>....<<<<<........<<<<.....>>> >..........>>>>>......<<<<<(((...<<<<<.....<<.)))> >.......>>>>>>>>>>..>>>>>>>>>..........<<<((.....< <<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>> >....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....< <<<<<<.<..<<<......>>>.....>.>>>>>>>...........<<. ...>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<... <<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<<<<. .<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.>>> .<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<< .<<.<<<<<<..<<<<<<<<<<......<<........>>.......... <<<<<<<......<<<<<<<...<<<<<<<....>>>>>>>....<<... ...>>....>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<<.. ..>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<..<< <..<<<.....>>>>>>...>>>>>>>.....<<<<<....>>>>>.... ....>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>.>> >>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>>.. ..>>>.....>>>>>>>......<....<<<<<<<........>>>>>>> ....>.....>>>>>>....<<<<<<<..........>>>>>>>...... >>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<<<< <<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>>.. >>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>.....

Receptor-Ligand Complex Structure Global view Local view Structure summary [Spin on] [Spin off] [Reset] [High quality] [Low quality] [White background] [Black background] [Spin on] [Spin off] [Reset] [High quality] [Low quality] [White background] [Black background] PDB 5w4k Klebsazolicin inhibits 70S ribosome by obstructing the peptide exit tunnel. Resolution 2.7 Å Binding residue (original residue number in PDB) A2 R3 K4 A5 L6 E8 K9 K15 F16 K17 V18 R19 Y21 T22 R23 C27 R29 R31 S32 Y34 R35 I42 R45 E46 K58 S60 W61 Binding residue (residue number reindexed from 1) A1 R2 K3 A4 L5 E7 K8 K14 F15 K16 V17 R18 Y20 T21 R22 C26 R28 R30 S31 Y33 R34 I41 R44 E45 K57 S59 W60

Enzymatic activity Enzyme Commision number ?

Gene Ontology Molecular Function GO:0003735 structural constituent of ribosome GO:0008270 zinc ion binding GO:0019843 rRNA binding GO:0046872 metal ion binding

	Biological Process
GO:0006412	translation

	Cellular Component
GO:0005737	cytoplasm
GO:0005840	ribosome
GO:0015935	small ribosomal subunit
GO:1990904	ribonucleoprotein complex

View graph for Molecular Function

View graph for Biological Process

View graph for Cellular Component