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Structure of PDB 5hau Chain 2c Binding Site BS01

Receptor Information >5hau Chain 2c (length=206) Species: 300852 (Thermus thermophilus HB8) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure] GNKIHPIGFRLGITRDWESRWYAGKKQYRHLLLEDQRIRGLLEKELYSAG LARVDIERAADNVAVTVHVAKPGVVIGRGGERIRVLREELAKLTGKNVAL NVQEVQNPNLSAPLVAQRVAEQIERRFAVRRAIKQAVQRVMESGAKGAKV IVSGRIGGAEQARTEWAAQGRVPLHTLRANIDYGFALARTTYGVLGVKAY IFLGEV

Ligand information >5hau Chain 2a (length=1501) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure] uuggagaguuugauccuggcucagggugaacgcuggcggcgugccuaaga caugcaagucgugcgggccgcgggguacuccguggucagcggcggacggg ugaguaacgcgugggugaccuacccggaagagggggacaacccggggaaa cucgggcuaaucccccauguggacccgccccuugggguguguccaaaggg cuuugcccgcuuccggaugggcccgcgucccaucagcuaguugguggggu aauggcccaccaaggcgacgacggguagccggucugagaggauggccggc cacaggggcacugagacacgggccccacuccuacgggaggcagcaguuag gaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggagga agaagcccuucgggguguaaacuccugaacccgggacgaaacccccgacg aggggacugacgguaccgggguaauagcgccggccaacuccgugccagca gccgcgguaauacggagggcgcgagcguuacccggauucacugggcguaa agggcguguaggcggccuggggcgucccaugugaaagaccacggcucaac cgugggggagcgugggauacgcucaggcuagacggugggagaggguggug gaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccgau ggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcgug gggagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcg cgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgc cgccuggggaguacggccgcaaggcugaaacucaaaggaauugacggggg cccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaac cuuaccaggccuugacaugcuagggaacccgggugaaagccuggggugcc ccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucgug ccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguuag uugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcggg aggaaggaggggacgacgucuggucagcauggcccuuacggccugggcga cacacgugcuacaaugcccacuacaaagcgaugccacccggcaacgggga gcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgac cccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcgguga auacguucccgggccuuguacacaccgcccgucacgccaugggagcgggc ucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggccc gugacuggggcggucguaacaagguagcuguaccggaaggugcggcugga u .....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<< <.<<<..<<<..<<.<<<<<<<<<....>>>>>>>>>.>>>>>......< <.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<..... .>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..<<< <...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.. .....>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>> .>>.<<<<<.<.........>>>>>>.<<<<<..>>>>>...>>>>>>>. .......<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<.. ....<<<<....>>>>.....>>>>....<<<<<........<<<<.... .>>>>..........>>>>>......<<<<<(((...<<<<<.....<<. )))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.. ...<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....> >>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<. ...<<<<<<<.<..<<<......>>>.....>.>>>>>>>.......... .<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<< <...<<...<<<<.<.....>.>>>>...>>>>>>>>..........<<< <<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>> .>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<< <<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>...... ....<<<<<<<......<<<<<<<<..<<<<<<<....>>>>>>>....< <......>>...>>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<< <<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<< ..<<<..<<<.....>>>>>>...>>>>>>>.....<<<<<....>>>>> ........>>>>.........>>>...>>>>>>>>>...>>>>>>>...> >.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>.. >>....>>>.....>>>>>>>...........<<<<<<<........>>> >>>>..........>>>>>>....<<<<<<<..........>>>>>>>.. ....>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<< <<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>> >>..>>>.>>>>>.>>...>.....<<<<<<<<<....>>>>>>>>>... .

Receptor-Ligand Complex Structure Global view Local view Structure summary [Spin on] [Spin off] [Reset] [High quality] [Low quality] [White background] [Black background] [Spin on] [Spin off] [Reset] [High quality] [Low quality] [White background] [Black background] PDB 5hau Structures of proline-rich peptides bound to the ribosome reveal a common mechanism of protein synthesis inhibition. Resolution 3.0 Å Binding residue (original residue number in PDB) G2 N3 K4 I5 F10 K26 R127 S154 R156 E161 A163 G171 R172 V173 P174 L175 H176 T177 L178 R179 T192 Y193 G194 V195 G197 K199 Binding residue (residue number reindexed from 1) G1 N2 K3 I4 F9 K25 R126 S153 R155 E160 A162 G170 R171 V172 P173 L174 H175 T176 L177 R178 T191 Y192 G193 V194 G196 K198

Enzymatic activity Enzyme Commision number ?

Gene Ontology Molecular Function GO:0003676 nucleic acid binding GO:0003723 RNA binding GO:0003729 mRNA binding GO:0003735 structural constituent of ribosome GO:0019843 rRNA binding

	Biological Process
GO:0006412	translation

	Cellular Component
GO:0005840	ribosome
GO:0022627	cytosolic small ribosomal subunit
GO:1990904	ribonucleoprotein complex

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