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BioLiP

Structure of PDB 1f6u Chain A Binding Site BS01

Receptor Information
>1f6u Chain A (length=55) Species: 11676 (Human immunodeficiency virus 1) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MQKGNFRNQRKTVKCFNCGKEGHIAKNCRAPRKKGCWKCGKEGHQMKDCT
ERQAN
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB1f6u NMR structure of the HIV-1 nucleocapsid protein bound to stem-loop SL2 of the psi-RNA packaging signal. Implications for genome recognition.
ResolutionN/A
Binding residue
(original residue number in PDB)		K3 Q9 K14 F16 I24 A25 K26 N27 R32 G35 C36 W37 Q45 M46
Binding residue
(residue number reindexed from 1)		K3 Q9 K14 F16 I24 A25 K26 N27 R32 G35 C36 W37 Q45 M46
Binding affinityPDBbind-CN: Kd=110nM
Enzymatic activity
Enzyme Commision number 2.7.7.-
2.7.7.49: RNA-directed DNA polymerase.
2.7.7.7: DNA-directed DNA polymerase.
3.1.-.-
3.1.13.2: exoribonuclease H.
3.1.26.13: retroviral ribonuclease H.
3.4.23.16: HIV-1 retropepsin.
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0008270 zinc ion binding

View graph for
Molecular Function
External links
PDB RCSB:1f6u, PDBe:1f6u, PDBj:1f6u
PDBsum1f6u
PubMed10926523
UniProtP35963|POL_HV1Y2 Gag-Pol polyprotein (Gene Name=gag-pol)

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