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Structure of PDB 1t5x Chain A Binding Site BS01

Receptor Information
>1t5x Chain A (length=179) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
EHVIIQAEFYLNPDQSGEFMFDFDGDEIFHVDMAKKETVWRLEEFGRFAS
FEAQGALANIAVDKANLEIMTKRSNYTPITNVPPEVTVLTNSPVELREPN
VLICFIDKFTPPVVNVTWLRNGKPVTTGVSETVFLPREDHLFRKFHYLPF
LPSTEDVYDCRVEHWGLDEPLLKHWEFDA
Ligand information
>1t5x Chain C (length=13) Species: 559292 (Saccharomyces cerevisiae S288C) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
AAYSDQATPLLLS
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB1t5x A Polymorphic Pocket at the P10 Position Contributes to Peptide Binding Specificity in Class II MHC Proteins
Resolution2.5 Å
Binding residue
(original residue number in PDB)		Q9 A52 S53 F54 N62 V65 N69 M73
Binding residue
(residue number reindexed from 1)		Q6 A49 S50 F51 N59 V62 N66 M70
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Biological Process
GO:0006955 immune response
GO:0019882 antigen processing and presentation
Cellular Component
GO:0016020 membrane
GO:0042613 MHC class II protein complex

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Biological Process
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Cellular Component
External links
PDB RCSB:1t5x, PDBe:1t5x, PDBj:1t5x
PDBsum1t5x
PubMed15489166
UniProtP01903|DRA_HUMAN HLA class II histocompatibility antigen, DR alpha chain (Gene Name=HLA-DRA)

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