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BioLiP

Structure of PDB 4fl8 Chain A Binding Site BS01

Receptor Information
>4fl8 Chain A (length=99) Species: 11676 (Human immunodeficiency virus 1) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
PQITLWKRPLVTIKIGGQLKEALLDTGADDTVIEEMSLPGRWKPKMIGGI
GGFIKVRQYDQIIIEIAGHKAIGTVLVGPTPVNIIGRNLLTQIGATLNF
Ligand information
>4fl8 Chain C (length=7) Species: 11676 (Human immunodeficiency virus 1) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
QIIIEIA
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB4fl8 Capturing the Reaction Pathway in Near-Atomic-Resolution Crystal Structures of HIV-1 Protease.
Resolution1.2 Å
Binding residue
(original residue number in PDB)		R8 D25 G27 D29 I47 G48 I84
Binding residue
(residue number reindexed from 1)		R8 D25 G27 D29 I47 G48 I84
Enzymatic activity
Catalytic site (original residue number in PDB) D25 T26 G27
Catalytic site (residue number reindexed from 1) D25 T26 G27
Enzyme Commision number 2.7.7.-
2.7.7.49: RNA-directed DNA polymerase.
2.7.7.7: DNA-directed DNA polymerase.
3.1.-.-
3.1.13.2: exoribonuclease H.
3.1.26.13: retroviral ribonuclease H.
3.4.23.16: HIV-1 retropepsin.
Gene Ontology
Molecular Function
GO:0004190 aspartic-type endopeptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:4fl8, PDBe:4fl8, PDBj:4fl8
PDBsum4fl8
PubMed22963370
UniProtP03367|POL_HV1BR Gag-Pol polyprotein (Gene Name=gag-pol)

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