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BioLiP

Structure of PDB 4jcj Chain A Binding Site BS01

Receptor Information
>4jcj Chain A (length=144) Species: 10090 (Mus musculus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
ISLCVGCGNQIHDQYILRVSPDLEWHAACLKCAECNQYLDESCTCFVRDG
KTYCKRDYIRLYGIKCAKCSIGFSKNDFVMRARSKVYHIECFRCVACSRQ
LIPGDEFALREDGLFCRADHDDVMVVGEPTLMDEDERLITRLEN
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain4jcj Chain A Residue 401 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB4jcj A structural basis for the regulation of the LIM-homeodomain protein islet 1 (Isl1) by intra- and intermolecular interactions.
Resolution3.0 Å
Binding residue
(original residue number in PDB)		C17 C20 H39 C42
Binding residue
(residue number reindexed from 1)		C4 C7 H26 C29
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
Biological Process
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0048665 neuron fate specification

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Molecular Function
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Biological Process
External links
PDB RCSB:4jcj, PDBe:4jcj, PDBj:4jcj
PDBsum4jcj
PubMed23750000
UniProtP61372;
P70662|LDB1_MOUSE LIM domain-binding protein 1 (Gene Name=Ldb1)

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