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BioLiP

Structure of PDB 5ink Chain A Binding Site BS01

Receptor Information
>5ink Chain A (length=254) Species: 10090 (Mus musculus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GLEDSSTISFITWNIDGLDGCNLPERARGVCSCLALYSPDVVFLQEVIPP
YCAYLKKRAASYTIITGNEEGYFTAILLKKGRVKFKSQEIIPFPNTKMMR
NLLCVNVSLGGNEFCLMTSHLESTREHSAERIRQLKTVLGKMQEAPDSTT
VIFAGDTNLRDQEVIKCGGLPDNVFDAWEFLGKPKHCQYTWDTKANNNLR
IPAAYKHRFDRIFFRAEEGHLIPQSLDLVGLEKLDCGRFPSDHWGLLCTL
NVVL
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB5ink Reversal of DNA damage induced Topoisomerase 2 DNA-protein crosslinks by Tdp2.
Resolution2.15 Å
Binding residue
(original residue number in PDB)		H236 S239 T240 D272 N274 R276 W307 I317 Y321 H323 H359
Binding residue
(residue number reindexed from 1)		H120 S123 T124 D156 N158 R160 W191 I201 Y205 H207 H243
Enzymatic activity
Enzyme Commision number 3.1.4.-
Gene Ontology
Molecular Function
GO:0003824 catalytic activity

View graph for
Molecular Function
External links
PDB RCSB:5ink, PDBe:5ink, PDBj:5ink
PDBsum5ink
PubMed27060144
UniProtQ9JJX7|TYDP2_MOUSE Tyrosyl-DNA phosphodiesterase 2 (Gene Name=Tdp2)

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