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Structure of PDB 5qix Chain A Binding Site BS01

Receptor Information >5qix Chain A (length=223) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure] FNLISEKCDILSILRDHPENRIYRRKIEELSKRFTAIRKTKGDRNCFYRA LGYSYLESLLGKSREIFKFKERVLQTPNDLLAAGFEEHKFRNFFNAFYSV VELVEKDGSVSSLLKVFNDQSASDHIVQFLRLLTSAFIRNRADFFRHFIE MDIKDFCTHEVEPMATECDHIQITALSQALSIALQVEYVDEMDTALNHHV FPEAATPSVYLLYKTSHYNILYA

Ligand information Ligand ID J5V InChI InChI=1S/C11H11NO/c1-10(13)12-9-5-8-11-6-3-2-4-7-11/h2-4,6-7H,9H2,1H3,(H,12,13) InChIKey MEDMJWLHQZDCBX-UHFFFAOYSA-N SMILES Software SMILES ACDLabs 12.01 C(c1ccccc1)#CCNC(=O)C CACTVS 3.385 OpenEye OEToolkits 2.0.6 CC(=O)NCC#Cc1ccccc1 Formula C11 H11 N O Name N-(3-phenylprop-2-yn-1-yl)acetamide ChEMBL DrugBank ZINC PDB chain 5qix Chain A Residue 301 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure Global view Local view Structure summary [Spin on] [Spin off] [Reset] [High quality] [Low quality] [White background] [Black background] [Spin on] [Spin off] [Reset] [High quality] [Low quality] [White background] [Black background] PDB 5qix Covalent fragment group deposition Resolution 1.39 Å Binding residue (original residue number in PDB) G47 R49 C51 T222 H224 Binding residue (residue number reindexed from 1) G42 R44 C46 T215 H217 Annotation score 1

Enzymatic activity Enzyme Commision number 3.4.19.12: ubiquitinyl hydrolase 1.

Gene Ontology Molecular Function GO:0004843 cysteine-type deubiquitinase activity GO:0005515 protein binding GO:0008234 cysteine-type peptidase activity GO:0016787 hydrolase activity GO:0043130 ubiquitin binding

	Biological Process
GO:0006508	proteolysis
GO:0016579	protein deubiquitination
GO:0035871	protein K11-linked deubiquitination
GO:0070536	protein K63-linked deubiquitination
GO:0071108	protein K48-linked deubiquitination
GO:2000780	negative regulation of double-strand break repair

	Cellular Component
GO:0005634	nucleus

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