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BioLiP

Structure of PDB 6uuq Chain A Binding Site BS01

Receptor Information
>6uuq Chain A (length=311) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SHRLTAKEVFDNDGKPRVDILKAHLMKEGRLEESVALRIITEGASILRQE
KNLLDIDAPVTVCGDIHGQFFDLMKLFEVGGSPANTRYLFLGDYVDRGYF
SIECVLYLWALKILYPKTLFLLRGNHECRHLTEYFTFKQECKIKYSERVY
DACMDAFDCLPLAALMNQQFLCVHGGLSPEINTLDDIRKLDRFKEPPAYG
PMCDILWSDPLEDFGNEKTQEHFTHNTVRGCSYFYSYPAVCEFLQHNNLL
SILRAHEAQDAGYRMYRKSQTTGFPSLITIFSAPNYLDVYNNKAAVLKYE
NNVMNIRQFNC
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6uuq The structure of the RCAN1:CN complex explains the inhibition of and substrate recruitment by calcineurin.
Resolution1.849 Å
Binding residue
(original residue number in PDB)		L275 Y288 M290 F299 Y324 N327 V328 M329 N330 I331 Q333 F334 C336
Binding residue
(residue number reindexed from 1)		L250 Y263 M265 F274 Y299 N302 V303 M304 N305 I306 Q308 F309 C311
Enzymatic activity
Enzyme Commision number 3.1.3.16: protein-serine/threonine phosphatase.
Gene Ontology
Molecular Function
GO:0016787 hydrolase activity
GO:0033192 calmodulin-dependent protein phosphatase activity
Biological Process
GO:0097720 calcineurin-mediated signaling

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Molecular Function
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Biological Process
External links
PDB RCSB:6uuq, PDBe:6uuq, PDBj:6uuq
PDBsum6uuq
PubMed32936779
UniProtQ08209|PP2BA_HUMAN Protein phosphatase 3 catalytic subunit alpha (Gene Name=PPP3CA)

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