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Structure of PDB 7wmg Chain A Binding Site BS01

Receptor Information
>7wmg Chain A (length=225) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KPEPTDEEWELIKTVTEAHVATNAQSHKQKRKFLDLEAFSHFTKIITPAI
TRVVDFAKKLPMFCELPCEDQIILLKGCCMEIMSLRAAVRYDPESETLTL
NGEMAVTRGQLKNGGLGVVSDAIFDLGMSLSSFNLDDTEVALLQAVLLMS
SDRPGLACVERIEKYQDSFLLAFEHYINYRKHHVTHFWPKLLMKVTDLRM
IGACHASFLHMKPTELFPPLFLEVF
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7wmg Discovery of a Highly Selective and H435R-Sensitive Thyroid Hormone Receptor beta Agonist.
Resolution2.93 Å
Binding residue
(original residue number in PDB)		K288 E299 I302 L305 K306 L454 E457
Binding residue
(residue number reindexed from 1)		K58 E69 I72 L75 K76 L220 E223
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004879 nuclear receptor activity
Biological Process
GO:0006355 regulation of DNA-templated transcription

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Molecular Function
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Biological Process
External links
PDB RCSB:7wmg, PDBe:7wmg, PDBj:7wmg
PDBsum7wmg
PubMed35507418
UniProtP10828|THB_HUMAN Thyroid hormone receptor beta (Gene Name=THRB)

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