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●I-TASSER ●I-TASSER-MTD ●C-I-TASSER ●CR-I-TASSER ●QUARK ●C-QUARK ●LOMETS ●MUSTER ●CEthreader ●SEGMER ●DeepFold ●DeepFoldRNA ●FoldDesign ●COFACTOR ●COACH ●MetaGO ●TripletGO ●IonCom ●FG-MD ●ModRefiner ●REMO ●DEMO ●DEMO-EM ●SPRING ●COTH ●Threpp ●PEPPI ●BSpred ●ANGLOR ●EDock ●BSP-SLIM ●SAXSTER ●FUpred ●ThreaDom ●ThreaDomEx ●EvoDesign ●BindProf ●BindProfX ●SSIPe ●GPCR-I-TASSER ●MAGELLAN ●ResQ ●STRUM ●DAMpred

●TM-score ●TM-align ●US-align ●MM-align ●RNA-align ●NW-align ●LS-align ●EDTSurf ●MVP ●MVP-Fit ●SPICKER ●HAAD ●PSSpred ●3DRobot ●MR-REX ●I-TASSER-MR ●SVMSEQ ●NeBcon ●ResPRE ●TripletRes ●DeepPotential ●WDL-RF ●ATPbind ●DockRMSD ●DeepMSA ●FASPR ●EM-Refiner ●GPU-I-TASSER

●BioLiP ●E. coli ●GLASS ●GPCR-HGmod ●GPCR-RD ●GPCR-EXP ●Tara-3D ●TM-fold ●DECOYS ●POTENTIAL ●RW/RWplus ●EvoEF ●HPSF ●THE-DB ●ADDRESS ●Alpaca-Antibody ●CASP7 ●CASP8 ●CASP9 ●CASP10 ●CASP11 ●CASP12 ●CASP13 ●CASP14

Structure of PDB 8h0v Chain A Binding Site BS01

Receptor Information >8h0v Chain A (length=1412) Species: 460519 (Komagataella phaffii) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure] SQFPYSSAPLRSVKEVQFGLLSPEEIRAISVVKIEYPEIMDESRQRPREG GLNDPKLGSIDRNFKCQTCGEGMAECPGHFGHMELAKPVFHIGFIPKIKK VCECICMNCGKLLLDETNPTMAQAIRIRDPKKRFNAVWQLCKTKMVCEAD APKVVSRGGCGNTQPVVRKDGMKLWGTWKKSAQPERKLLTPGEILNVFKH ISPEDCFRLGFNEDYARPEWMIITVLPVPPPQVRPSIAMDETTQGQDDLT HKLSDILKANINVQKLEMDGSPQHIINEVEQLLQFHVATYMDNDIAGQPQ ALQKSGRPVKAIRARLKGKEGRLRGNLMGKRVDFSARTVISGDPNLELDQ VGVPISIAKTLSYPETVTQYNIHRLTEYVRNGPNEHPGAKYVIRDNGDRI DLRYHKRAGDIVLQYGWKVERHLMDDDPVLFNRQPSLHKMSMMAHRVKVM PYSTFRLNLSVTSPYNADFDGDEMNLHVPQSEETRAELSQLCAVPLQIVS PQSNKPVMGIVQDTLCGVRKMTLRDTFIEYEQVMNMLFWVPSWDGVVPQP AILKPKPLWTGKQLLSIAIPSGIHLQRTDGGNSLLSPKDNGMLIVDGKVM FGVVDKKTVGSGGGGLIHTVMREKGPKICAELFGNIQKVVNYWLLHNGFS IGIGDAIADASTMKEITHAISSAKEQVQEIIYKAQHNELELKPGMTLRES FEGEVSRTLNDARDSAGRSAEMNLKDLNNVKQMVSAGSKGSFINIAQMSA CVGQQMVEGKRIAFGFADRSLPHFTKDDFSPESKGFVENSYLRGLTPQEF FFHAMAGREGLIDTAVKTAETGYIQRRLVKALEDIMVHYDGTTRNSLGDI IQFLYGEDGLDGTQVERQTIDTIPGSDKAFHKRYYVDLMDEKNSIKPDVI EYAADILGDVELQKELNSEYEQLVSDRKFLREIVFVNGDHNWPLPVNLRR IIQNAQQIFHLDRAKASDLTIPEIIHGVRDLCKKLFVLRGENELIKEAQQ NATSLFQCLVRARLATRRILEEFRLNRDAFEWVLGTIEAQFQRSLVHPGE MVGVIAAQSIGEPATQMNVTLGVPRLKEILNVAKNIKTPALTVYLDREIA LDIEKAKVIQSSIEYTTLKNVTSATEIYYDPDPTSTVIEEDFDTVEAYFS QSPWLLRLELDRARMLDKQLTMNQVADKISEVFSDDLFVMWSEDNADKLI IRCRVIEEDQMLKRIEAHMLDLIALRGIPGISKVYMVKHKVSVPDESGEY KNEELWALETDGINLAEVMAVPGVDSSRTYSNSFVEILSVLGIEATRSSL YKEILNVIAFDGSYVNYRHMALLVDVMTSRGYLMAITRHGINRADTGALM RCSFEETVEILFEAGAAAELDDCRGVSENVMLGQLAPMGTGAFDVMIDEK LLTSLPADYAPT

Ligand information >8h0v Chain P (length=14) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure] agcaauaggagcuu ..............

Receptor-Ligand Complex Structure Global view Local view Structure summary [Spin on] [Spin off] [Reset] [High quality] [Low quality] [White background] [Black background] [Spin on] [Spin off] [Reset] [High quality] [Low quality] [White background] [Black background] PDB 8h0v Structural basis of RNA polymerase II transcription on the chromatosome containing linker histone H1. Resolution 3.8 Å Binding residue (original residue number in PDB) R63 I251 A252 M253 R321 R447 P449 N480 D486 Binding residue (residue number reindexed from 1) R62 I237 A238 M239 R307 R433 P435 N466 D472

Enzymatic activity Enzyme Commision number 2.7.7.6: DNA-directed RNA polymerase.

Gene Ontology Molecular Function GO:0001055 RNA polymerase II activity GO:0003677 DNA binding GO:0003899 DNA-directed 5'-3' RNA polymerase activity GO:0016779 nucleotidyltransferase activity GO:0034062 5'-3' RNA polymerase activity GO:0046872 metal ion binding

	Biological Process
GO:0006351	DNA-templated transcription
GO:0006366	transcription by RNA polymerase II

	Cellular Component
GO:0000428	DNA-directed RNA polymerase complex
GO:0005634	nucleus
GO:0005665	RNA polymerase II, core complex

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