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Structure of PDB 4wzo Chain A8 Binding Site BS01

Receptor Information >4wzo Chain A8 (length=111) Species: 300852 (Thermus thermophilus HB8) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure] ARLTAYERRKFRVRNRIKRTGRLRLSVFRSLKHIYAQIIDDEKGVTLVSA SSLALKLKGNKTEVARQVGRALAEKALALGIKQVAFDRGPYKYHGRVKAL AEGAREGGLEF

Ligand information >4wzo Chain 1H (length=2902) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure] agaugguaagggcccacgguggaugccucggcacccgagccgaugaagga cguggcuaccugcgauaagccagggggagccgguagcgggcguggauccc uggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgc uuuuugcgcggggggaaccuggggaacugaaacaucucaguacccagagg agaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggacca gccuaaaccguccggcuuguccgggcggggucguggggcccucggacacc gaauccccagccuagccgaagcuguugggaagcagcgccagagaggguga aagccccguaggcgaaagguggggggauaggugaggguacccgaguaccc cgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcu aaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaa aagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaa gcagucacggccccgcaagggguuguggcgugccuauugaagcaugagcc ggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagg gaaaccgaguccgaacagggcgcaaacggcccgcacgcgggccgaaaagu ccgcggccguggacccgaaaccgggcgagcuagcccuggccagggugaag cuggggugagacccaguggaggcccgaaccggugggggaugcaaaccccu cggaugagcuggggcuaggagugaaaagcuaaccgagcccggagauagcu gguucuccccgaaaugacuuuagggucagccucaggcgcugacuggggcc uguagagcacugauagggcuagggggcccaccagccuaccaaacccuguc aaacuccgaagggucccagguggagccugggagugagggcgcgagcgaua acguccgcguccgagcgcgggaacaaccgagaccgccagcuaaggccccc aagucugggcuaagugguaaaggauguggcgccgcgaagacagccaggau guuggcuuagaagcagccaucauuuaaagagugcguaauagcucacuggu cgaguggcgccgcgccgaaaaugaucggggcuuaagcccagcgccgaagc ugcgggucugggggaugaccccaggcgguaggggagcguucccgaugccg augaaggccgacccgcgagggcggcuggagguaagggaagugcgaaugcc ggcaugaguaacgauaaagagggugagaaucccucucgccguaagcccaa ggguuccuacgcaauggucgucagcguaggguuaggcgggaccuaaggug aagccgaaaggcguagccgaagggcagccgguuaauauuccggcccuucc cgcaggugcgauggggggacgcucuaggcuagggggaccggagccaugga cgagcccggccagaagcgcagggugggagguaggcaaauccgccucccaa caagcucugcgugguggggaagcccguacgggugacaaccccccgaagcc agggagccaagaaaagccucuaagcacaaccugcgggaacccguaccgca aaccgacacaggugggcgggugcaagagcacucaggcgcgcgggagaacc cucgccaaggaacucugcaaguuggccccguaacuucgggagaaggggug cucccuggggugaugagccccggggagccgcagugaacaggcucuggcga cuguuuaccaaaaacacagcucucugcgaacucguaagaggagguauagg gagcgacgcuugcccggugccggaaggucaaggggaggggugcaagcccc gaaccgaagccccggugaacggcggccguaacuauaacgguccuaaggua gcgaaauuccuugucggguaaguuccgaccugcacgaaaagcguaacgac cggagcgcugucucggcgagggacccggugaaauugaacuggccgugaag augcggccuacccguggcaggacgaaaagaccccguggagcuuuacugca gccugguguuggcucuuggucgcgccugcguaggauaggugggagccugu gaacccccgccuccgggugggggggaggcgccggugaaauaccacccugg cgcggcugggggccuaacccucggauggggggacagcgcuuggcgggcag uuugacuggggcggucgccuccuaaaagguaacggaggcgcccaaagguc cccucaggcgggacggaaauccgccggagagcgcaaggguagaagggggc cugacugcgaggccugcaagccgagcaggggcgaaagccgggccuaguga accgguggucccguguggaagggccaucgaucaacggauaaaaguuaccc cggggauaacaggcugaucucccccgagcguccacagcggcggggagguu uggcaccucgaugucggcucgucgcauccuggggcugaagaaggucccaa ggguugggcuguucgcccauuaaagcggcacgcgagcuggguucagaacg ucgugagacaguucggucucuauccgccacgggcgcaggaggcuugaggg gggcucuuccuaguacgagaggaccggaagggacgcaccucugguuuccc agcugucccuccaggggcauaagcuggguagccaugugcggaagggauaa ccgcugaaagcaucuaagcgggaagcccgccccaagaugaggccucccac ggcgucaagccgguaaggacccgggaagaccacccgguggaugggccggg gguguaagcgccgcgaggcguugagccgaccggucccaaucguccgaggu cu <<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<< <<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>> >>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<< .....>>>>>>.>>...<<<<<<.....<......>......>>>>>.>. ........<<....>>...<<<<<.....<<.....>>....>>>>>... <<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<....<<< ...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<... ..))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<< <<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>. .....>>.>>>>>>.>>...............<<....>>....>>.... .....<<<<....>>>>..................>>>>>>>>>>>.... ...<<<<<<<<<<<....>>>>>>>>>>>...<............>.<<< <<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<< ....>>..<<<<.....>>>>.....<<<<<<......>>>>>>....>> >>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<<....< <<<<<......>>>>>>.....>>>...<<<..<<<<........>>>>. >>>....>>>>>>>>>...<<<.....>>>......>>>>>>......>. >>..<<<<<<....<<<<<....>>>>><<<<<<<<<.....<<<<<<<< <...<<<...<<<<<<<<.......<<......>>........>>>>>>> >..>>.>...>>>>>>>>>.....>>>>>>>.>>..<<<<<<<.<<.... ..>>.>>>>>>>.....<<<......>>>...<<<<.<<<...<<<(((. ....<<<<<<...........<<..<<<<<<<<<........<<<<<.<< .....<.........>.....>>.........<<......>>...>>>>> ....>>>>>>>>>.>>..........)))......>>>>>>.>>>...>> >>>>><<<<<<<<.....>>>>>>>>....>>>>>>..<<<<<...<<<. .....<<<<<.<<<....>>>>>>>>...>>>..>>>>>........>>> >>><......<<.....<<<<<<.......>>>>>><<<<....<<<<<. <<...<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<. ..<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<< <<<<<<<<<...<<<<....<<<<<.<<<..<<<<<.<<<<.<<..[[[[ ...>>>>>><<<...<<<<<<<<<<<<<<<<.<<.....>>>>>>>>>.. ...>>>>>>>>>..>>><...<<<<....>>>>.....>>>>>>...>>> ..>>>>>.........>>>>...>>...>>>>>>>>>>>>>>>..>>... ..<<......>>>>>>>.<<<<<....>>>>>..>>>>..<<<<....<< <<<<<<.<<.........<.....<<<<<...............>>>>>< <<<<<<<<<<<.....>>>>>>>>>>>>............<<<<<<<<<. .<<<.........>>>..<<<<<<<.....<<<....>>>.......>>> >>>>.<<<<<.<<<..<<<<<<<..<<<...<<...<<<<<....>>>>> ...>>...>>>>>>>>..>>>>><<<<<<.......>>>>>>........ <...........<<<<<<.....>>>>>>.....>....>>>>>..>>.> >>>>>>..>..>>.>>>>>>>>.>>>>>>.....>.....<<<<<..... ...>>>>>..<<<<<<<<.<<<.........<<<<.<<<<<<..<<<<<. <<<.<<<<<.<<<<<<.<<<<<<<<<...........<<.<<..<<<... ...<<<<<<<<....>>>>>>>>...>>>............>>.>>..>> >>>>>>>.>>>>>>...<<<<<....>>>>>....>>>>>.>>>..>>>> >..<<<<.....>>>><<<<<<...........>>>>>>..<<...<<<< <<<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>> >...<<<<..<<<......>>>..>>>>.<<<....>>>.>>)))..... ..<<<<<<<.<<..))))..>>>>>>>>>.............>>>>..>> >>>>.......<<<<..<<<<<<<<..<<.......>>>..>>>>>>>.. .>>>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>>. .>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<< <<....>>>.>>>>........>>>>>>>>>>>....<<<<<<<...<<< <..<<<<<<<...............>>>>>>>.<<<<<...<<<<...<< <<<<<<<<<]]]]>>>>>>...>>>>>...>>>>.>>>>>...<<<.... <<<<<...........>>>>>....>>>.>>>>.......>>>>>>>... ................<<<<<<<<<.......>>>>>....<<<<<<<<. <<<....<<<<<....>>>>>...>>>..>>>>>.>>>...>>>>....> >>

Receptor-Ligand Complex Structure Global view Local view Structure summary [Spin on] [Spin off] [Reset] [High quality] [Low quality] [White background] [Black background] [Spin on] [Spin off] [Reset] [High quality] [Low quality] [White background] [Black background] PDB 4wzo Structural insights into the translational infidelity mechanism. Resolution 3.3 Å Binding residue (original residue number in PDB) A2 R3 R9 R10 F12 R13 N16 R17 T21 R23 F87 R89 Y94 E111 F112 Binding residue (residue number reindexed from 1) A1 R2 R8 R9 F11 R12 N15 R16 T20 R22 F86 R88 Y93 E110 F111

Enzymatic activity Enzyme Commision number ?

Gene Ontology Molecular Function GO:0003735 structural constituent of ribosome GO:0008097 5S rRNA binding GO:0019843 rRNA binding

	Biological Process
GO:0006412	translation

	Cellular Component
GO:0005737	cytoplasm
GO:0005840	ribosome
GO:0022625	cytosolic large ribosomal subunit
GO:1990904	ribonucleoprotein complex

View graph for Molecular Function

View graph for Biological Process

View graph for Cellular Component