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Structure of PDB 1diz Chain B Binding Site BS01

Receptor Information >1diz Chain B (length=282) Species: 562 (Escherichia coli) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure] MYTLNWQPPYDWSWMLGFLAARAVSSVETVADSYYARSLAVGEYRGVVTA IPDIARHTLHINLSAGLEPVAAECLAKMSRLFDLQCNPQIVNGALGRLGA ARPGLRLPGCVDAFEQGVRAILGQLVSVAMAAKLTARVAQLYGERLDDFP EYICFPTPQRLAAADPQALKALGMPLKRAEALIHLANAALEGTLPMTIPG DVEQAMKTLQTFPGIGRWTANYFALRGWQAKDVFLPDDYLIKQRFPGMTP AQIRRYAERWKPWRSYALLHIWYTEGWQPDEA

Ligand information >1diz Chain C (length=13) [Search DNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure] gacatgactgcct

Receptor-Ligand Complex Structure Global view Local view Structure summary [Spin on] [Spin off] [Reset] [High quality] [Low quality] [White background] [Black background] [Spin on] [Spin off] [Reset] [High quality] [Low quality] [White background] [Black background] PDB 1diz DNA bending and a flip-out mechanism for base excision by the helix-hairpin-helix DNA glycosylase, Escherichia coli AlkA. Resolution 2.5 Å Binding residue (original residue number in PDB) G123 Q124 L125 S127 V128 G214 I215 G216 W218 T219 D238 Y239 Binding residue (residue number reindexed from 1) G123 Q124 L125 S127 V128 G214 I215 G216 W218 T219 D238 Y239

Enzymatic activity Catalytic site (original residue number in PDB) W218 Y222 D238 Catalytic site (residue number reindexed from 1) W218 Y222 D238 Enzyme Commision number 3.2.2.21: DNA-3-methyladenine glycosylase II.

Gene Ontology Molecular Function GO:0003824 catalytic activity GO:0003905 alkylbase DNA N-glycosylase activity GO:0005515 protein binding GO:0008725 DNA-3-methyladenine glycosylase activity GO:0016787 hydrolase activity GO:0032131 alkylated DNA binding GO:0043916 DNA-7-methylguanine glycosylase activity GO:0052821 DNA-7-methyladenine glycosylase activity GO:0052822 DNA-3-methylguanine glycosylase activity

	Biological Process
GO:0006281	DNA repair
GO:0006284	base-excision repair
GO:0006285	base-excision repair, AP site formation
GO:0006307	DNA alkylation repair
GO:0006950	response to stress
GO:0006974	DNA damage response

	Cellular Component
GO:0005737	cytoplasm
GO:0032993	protein-DNA complex

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