Online Services

●I-TASSER ●I-TASSER-MTD ●C-I-TASSER ●CR-I-TASSER ●QUARK ●C-QUARK ●LOMETS ●MUSTER ●CEthreader ●SEGMER ●DeepFold ●DeepFoldRNA ●FoldDesign ●COFACTOR ●COACH ●MetaGO ●TripletGO ●IonCom ●FG-MD ●ModRefiner ●REMO ●DEMO ●DEMO-EM ●SPRING ●COTH ●Threpp ●PEPPI ●BSpred ●ANGLOR ●EDock ●BSP-SLIM ●SAXSTER ●FUpred ●ThreaDom ●ThreaDomEx ●EvoDesign ●BindProf ●BindProfX ●SSIPe ●GPCR-I-TASSER ●MAGELLAN ●ResQ ●STRUM ●DAMpred

●TM-score ●TM-align ●US-align ●MM-align ●RNA-align ●NW-align ●LS-align ●EDTSurf ●MVP ●MVP-Fit ●SPICKER ●HAAD ●PSSpred ●3DRobot ●MR-REX ●I-TASSER-MR ●SVMSEQ ●NeBcon ●ResPRE ●TripletRes ●DeepPotential ●WDL-RF ●ATPbind ●DockRMSD ●DeepMSA ●FASPR ●EM-Refiner ●GPU-I-TASSER

●BioLiP ●E. coli ●GLASS ●GPCR-HGmod ●GPCR-RD ●GPCR-EXP ●Tara-3D ●TM-fold ●DECOYS ●POTENTIAL ●RW/RWplus ●EvoEF ●HPSF ●THE-DB ●ADDRESS ●Alpaca-Antibody ●CASP7 ●CASP8 ●CASP9 ●CASP10 ●CASP11 ●CASP12 ●CASP13 ●CASP14

Structure of PDB 1w5q Chain B Binding Site BS01

Receptor Information >1w5q Chain B (length=318) Species: 208964 (Pseudomonas aeruginosa PAO1) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure] ANRAYPYTRLRRNRRDDFSRRLVRENVLTVDDLILPVFVLDGVNQRESIP SMPGVERLSIDQLLIEAEEWVALGIPALALFPVTPVEKKSLDAAEAYNPE GIAQRATRALRERFPELGIITDVCLCEFTTHGQCGILDDDGYVLNDVSID VLVRQALSHAEAGAQVVAPSDMMDGRIGAIREALESAGHTNVRVMAYSAK YASAYYGPFRNRATYQMDPANSDEALHEVAADLAEGADMVMVKPGMPYLD IVRRVKDEFRAPTFVYQVSGEYAMHMGAIQNGWLAESVILESLTAFKRAG ADGILTYFAKQAAEQLRR

Ligand information Ligand ID ZN InChI InChI=1S/Zn/q+2 InChIKey PTFCDOFLOPIGGS-UHFFFAOYSA-N SMILES Software SMILES CACTVS 3.341 [Zn++] ACDLabs 10.04 OpenEye OEToolkits 1.5.0 [Zn+2] Formula Zn Name ZINC ION ChEMBL CHEMBL1236970 DrugBank DB14532 ZINC PDB chain 1w5q Chain B Residue 1340 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure Global view Local view Structure summary [Spin on] [Spin off] [Reset] [High quality] [Low quality] [White background] [Black background] [Spin on] [Spin off] [Reset] [High quality] [Low quality] [White background] [Black background] PDB 1w5q Tracking the Evolution of Porphobilinogen Synthase Metal Dependence in Vitro Resolution 1.4 Å Binding residue (original residue number in PDB) C129 C131 C139 Binding residue (residue number reindexed from 1) C124 C126 C134 Annotation score 1

Enzymatic activity Catalytic site (original residue number in PDB) K205 K260 Catalytic site (residue number reindexed from 1) K200 K243 Enzyme Commision number 4.2.1.24: porphobilinogen synthase.

Gene Ontology Molecular Function GO:0004655 porphobilinogen synthase activity GO:0008270 zinc ion binding GO:0016829 lyase activity GO:0046872 metal ion binding

	Biological Process
GO:0006779	porphyrin-containing compound biosynthetic process
GO:0006782	protoporphyrinogen IX biosynthetic process
GO:0006783	heme biosynthetic process
GO:0033014	tetrapyrrole biosynthetic process

	Cellular Component
GO:0005829	cytosol

View graph for Molecular Function

View graph for Biological Process

View graph for Cellular Component