BioLiP

Structure of PDB 2fp7 Chain B Binding Site BS01

Receptor Information

>2fp7 Chain B (length=147) Species: 11082 (West Nile virus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

TTGVYRIMTSYQAGAGVMVEGVFHTLWHTTKGAALMSGEGRLDPYWGSVK
EDRLCYGGPWKLQHKWNGHDEVQMIVVEPGKNVKNVQTKPGVFKTPEGEI
GAVTLDYPTGTSGSPIVDKNGDVIGLYGNGVIMPNGSYISAIVQGER

Ligand information

>2fp7 Chain C (length=5) Species: 32630 (synthetic construct) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

cLKRR

Receptor-Ligand Complex Structure

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Structure summary

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PDB	2fp7 Structural basis for the activation of flaviviral NS3 proteases from dengue and West Nile virus.
Resolution	1.68 Å
Binding residue (original residue number in PDB)	H51 D129 Y130 T132 S135 Y150 G151 N152 G153 Y161
Binding residue (residue number reindexed from 1)	H28 D106 Y107 T109 S112 Y127 G128 N129 G130 Y138

Enzymatic activity

Enzyme Commision number

2.1.1.56: mRNA (guanine-N(7))-methyltransferase.
2.1.1.57: methyltransferase cap1.
2.7.7.48: RNA-directed RNA polymerase.
3.4.21.91: flavivirin.
3.6.1.15: nucleoside-triphosphate phosphatase.
3.6.4.13: RNA helicase.

Gene Ontology

	Molecular Function
GO:0003723	RNA binding
GO:0003724	RNA helicase activity
GO:0005524	ATP binding

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Molecular Function

PDB	RCSB:2fp7, PDBe:2fp7, PDBj:2fp7
PDBsum	2fp7
PubMed	16532006
UniProt	P06935\|POLG_WNV Genome polyprotein