Online Services

●I-TASSER ●I-TASSER-MTD ●C-I-TASSER ●CR-I-TASSER ●QUARK ●C-QUARK ●LOMETS ●MUSTER ●CEthreader ●SEGMER ●DeepFold ●DeepFoldRNA ●FoldDesign ●COFACTOR ●COACH ●MetaGO ●TripletGO ●IonCom ●FG-MD ●ModRefiner ●REMO ●DEMO ●DEMO-EM ●SPRING ●COTH ●Threpp ●PEPPI ●BSpred ●ANGLOR ●EDock ●BSP-SLIM ●SAXSTER ●FUpred ●ThreaDom ●ThreaDomEx ●EvoDesign ●BindProf ●BindProfX ●SSIPe ●GPCR-I-TASSER ●MAGELLAN ●ResQ ●STRUM ●DAMpred

●TM-score ●TM-align ●US-align ●MM-align ●RNA-align ●NW-align ●LS-align ●EDTSurf ●MVP ●MVP-Fit ●SPICKER ●HAAD ●PSSpred ●3DRobot ●MR-REX ●I-TASSER-MR ●SVMSEQ ●NeBcon ●ResPRE ●TripletRes ●DeepPotential ●WDL-RF ●ATPbind ●DockRMSD ●DeepMSA ●FASPR ●EM-Refiner ●GPU-I-TASSER

●BioLiP ●E. coli ●GLASS ●GPCR-HGmod ●GPCR-RD ●GPCR-EXP ●Tara-3D ●TM-fold ●DECOYS ●POTENTIAL ●RW/RWplus ●EvoEF ●HPSF ●THE-DB ●ADDRESS ●Alpaca-Antibody ●CASP7 ●CASP8 ●CASP9 ●CASP10 ●CASP11 ●CASP12 ●CASP13 ●CASP14

Structure of PDB 4wt8 Chain BU Binding Site BS01

Receptor Information >4wt8 Chain BU (length=99) Species: 300852 (Thermus thermophilus HB8) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure] RNLSALKRHRQSLKRRLRNKAKKSAIKTLSKKAIQLAQEGKAEEALKIMR KAESLIDKAAKGSTLHKNAAARRKSRLMRKVRQLLEAAGAPLIGGGLSA

Ligand information >4wt8 Chain Bb (length=1504) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure] uggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagac augcaagucgugcgggccgcgggguuuuacuccguggucagcggcggacg ggugaguaacgcgugggugaccuacccggaagagggggacaacccgggga aacucgggcuaaucccccauguggacccgccccuugggguguguccaaag ggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguugguggg guaauggcccaccaaggcgacgacggguagccggucugagaggauggccg gccacaggggcacugagacacgggccccacuccuacgggaggcagcaguu aggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggag gaagaagcccuucgggguguaaacuccugaacccgggacgaaacccccga cgaggggacugacgguaccgggguaauagcgccggccaacuccgugccag cagccgcgguaauacggagggcgcgagcguuacccggauucacugggcgu aaagggcguguaggcggccuggggcgucccaugugaaagaccacggcuca accgugggggagcgugggauacgcucaggcuagacggugggagagggugg uggaauucccggaguagcggugaaaugcgcagauaccgggaggaacgccg auggcgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcg uggggagcaaaccggauuagauacccggguaguccacgcccuaaacgaug cgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaagcgc gccgccuggggaguacggccgcaaggcugaaacucaaaggaauugacggg ggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaaga accuuaccaggccuugacaugcuagggaacccgggugaaagccuggggug ccccgcgaggggagcccuagcacaggugcugcauggccgucgucagcucg ugccgugagguguuggguuaagucccgcaacgagcgcaacccccgccguu aguugccagcgguucggccgggcacucuaacgggacugcccgcgaaagcg ggaggaaggaggggacgacgucuggucagcauggcccuuacggccugggc gacacacgugcuacaaugcccacuacaaagcgaugccacccggcaacggg gagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaacccg accccaugaagccggaaucgcuaguaaucgcggaucagccaugccgcggu gaauacguucccgggccuuguacacaccgcccgucacgccaugggagcgg gcucuacccgaagucgccgggagccuacgggcaggcgccgaggguagggc ccgugacuggggcgaagucguaacaagguagcuguaccggaaggugcggc ugga ....<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<< .<<<..<<<..<<.<<<<<<<<.........>>>>>>>>.>>>>>..... .<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<... ...>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>>>..< <<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<< .......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>> >>.>>.<<<<<.<.........>>>>>>.<<<<....>>>>...>>>>>> >........<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<< ......<<<<....>>>>.....>>>>....<<<<<........<<<<.. ...>>>>..........>>>>>......<<<<<(((...<<<<<.....< <.)))>>.......>>>>>>>>>>..>>>>>>>>>..........<<<(( .....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.... .>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<< <....<<<<<<<.<..<<<......>>>.....>.>>>>>>>........ ...<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<< <<<...<<...<<<<.........>>>>...>>>>>>>>..........< <<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>> >>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.< <<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>>.... ......<<<<<<<......<<<<<<<...<<<<<<<....>>>>>>>... ..<......>.....>>>>>>>.<<<.<<<..<<<<<<.......<<<<< <<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<< <<...<....<<.....>>.>.....>>>>>>>.....<<<<<....>>> >>........>>>>.........>>>...>>>>>>>>>...>>>>>>>.. .>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>> ..>>....>>>.....>>>>>>>...........<<<<<<<........> >>>>>>..........>>>>>>....<<<<<<<..........>>>>>>> ......>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<< <<<<<<<<<...<.<<<<....<<<<..>>>>.>>>>.>..>>>>>>>>> >>>>..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>> >...

Receptor-Ligand Complex Structure Global view Local view Structure summary [Spin on] [Spin off] [Reset] [High quality] [Low quality] [White background] [Black background] [Spin on] [Spin off] [Reset] [High quality] [Low quality] [White background] [Black background] PDB 4wt8 Bactobolin A Binds to a Site on the 70S Ribosome Distinct from Previously Seen Antibiotics. Resolution 3.4 Å Binding residue (original residue number in PDB) L10 K14 R15 S19 R22 R23 N26 K27 S31 T35 L36 K39 R57 K58 E60 S61 K65 K68 S70 K74 A78 R79 K81 S82 M85 R89 G101 G102 G103 L104 S105 Binding residue (residue number reindexed from 1) L3 K7 R8 S12 R15 R16 N19 K20 S24 T28 L29 K32 R50 K51 E53 S54 K58 K61 S63 K67 A71 R72 K74 S75 M78 R82 G94 G95 G96 L97 S98

Enzymatic activity Enzyme Commision number ?

Gene Ontology Molecular Function GO:0003723 RNA binding GO:0003735 structural constituent of ribosome GO:0019843 rRNA binding GO:0070181 small ribosomal subunit rRNA binding

	Biological Process
GO:0006412	translation

	Cellular Component
GO:0005829	cytosol
GO:0005840	ribosome
GO:0015935	small ribosomal subunit
GO:1990904	ribonucleoprotein complex

View graph for Molecular Function

View graph for Biological Process

View graph for Cellular Component