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Structure of PDB 6k1h Chain C Binding Site BS01

Receptor Information >6k1h Chain C (length=273) Species: 511145 (Escherichia coli str. K-12 substr. MG1655) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure] KKLTQSDIRGVFLRSNLFQGSWNFERMQALGFCFSMVPAIRRLYPENNEA RKQAIRRHLEFFNTQPFVAAPILGVTLALEEQRANGAEIDDGAINGIKVG LMGPLAGVGDPIFWGTVRPVFAALGAGIAMSGSLLGPLLFFILFNLVRLA TRYYGVAYGYSKGIDIVKDMGGGFLQKLTEGASILGLFVMGALVNKWTHV NIPLVVSRITDQTGKEHVTTVQTILDQLMPGLVPLLLTFACMWLLRKKVN PLWIIVGFFVIGIAGYACGLLGL

Ligand information Ligand ID MAN InChI InChI=1S/C6H12O6/c7-1-2-3(8)4(9)5(10)6(11)12-2/h2-11H,1H2/t2-,3-,4+,5+,6+/m1/s1 InChIKey WQZGKKKJIJFFOK-PQMKYFCFSA-N SMILES Software SMILES OpenEye OEToolkits 1.5.0 C(C1C(C(C(C(O1)O)O)O)O)O CACTVS 3.341 OC[CH]1O[CH](O)[CH](O)[CH](O)[CH]1O CACTVS 3.341 OC[C@H]1O[C@H](O)[C@@H](O)[C@@H](O)[C@@H]1O OpenEye OEToolkits 1.5.0 C([C@@H]1[C@H]([C@@H]([C@@H]([C@H](O1)O)O)O)O)O ACDLabs 10.04 OC1C(O)C(OC(O)C1O)CO Formula C6 H12 O6 Name alpha-D-mannopyranose; alpha-D-mannose; D-mannose; mannose ChEMBL CHEMBL365590 DrugBank ZINC ZINC000003860903 PDB chain 6k1h Chain C Residue 301 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure Global view Local view Structure summary [Spin on] [Spin off] [Reset] [High quality] [Low quality] [White background] [Black background] [Spin on] [Spin off] [Reset] [High quality] [Low quality] [White background] [Black background] PDB 6k1h Structure of the mannose transporter of the bacterial phosphotransferase system. Resolution 3.52 Å Binding residue (original residue number in PDB) Q32 W35 Q78 D123 W127 Binding residue (residue number reindexed from 1) Q19 W22 Q65 D110 W114 Annotation score 4

Enzymatic activity Enzyme Commision number ?

Gene Ontology Molecular Function GO:0022870 protein-N(PI)-phosphohistidine-mannose phosphotransferase system transporter activity

	Biological Process
GO:0009401	phosphoenolpyruvate-dependent sugar phosphotransferase system
GO:0015761	mannose transmembrane transport
GO:0015764	N-acetylglucosamine transport
GO:0098708	D-glucose import across plasma membrane
GO:1990539	fructose import across plasma membrane

	Cellular Component
GO:0005886	plasma membrane
GO:0016020	membrane
GO:1902495	transmembrane transporter complex

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