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BioLiP

Structure of PDB 4obd Chain D Binding Site BS01

Receptor Information
>4obd Chain D (length=99) Species: 11685 (HIV-1 M:B_ARV2/SF2) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
PQITLWKRPLVTIRIGGQLKEALLNTGADNTVLEEMNLPGKWKPKMIGGI
GGFIKVRQYDQIPIEICGHKAIGTVLVGPTPVNIIGRDLLTQIGCTLNF
Ligand information
>4obd Chain F (length=8) Species: 11676 (Human immunodeficiency virus 1) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
PGNFFQNR
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB4obd HIV-1 protease-substrate coevolution in nelfinavir resistance.
Resolution1.9 Å
Binding residue
(original residue number in PDB)		R8 L23 G27 A28 D29 I47 G48 G49 I84
Binding residue
(residue number reindexed from 1)		R8 L23 G27 A28 D29 I47 G48 G49 I84
Enzymatic activity
Catalytic site (original residue number in PDB) N25 T26 G27
Catalytic site (residue number reindexed from 1) N25 T26 G27
Enzyme Commision number 2.7.7.-
2.7.7.49: RNA-directed DNA polymerase.
2.7.7.7: DNA-directed DNA polymerase.
3.1.-.-
3.1.13.2: exoribonuclease H.
3.1.26.13: retroviral ribonuclease H.
3.4.23.16: HIV-1 retropepsin.
Gene Ontology
Molecular Function
GO:0004190 aspartic-type endopeptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:4obd, PDBe:4obd, PDBj:4obd
PDBsum4obd
PubMed24719428
UniProtP03369|POL_HV1A2 Gag-Pol polyprotein (Gene Name=gag-pol)

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