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Structure of PDB 5iwa Chain H Binding Site BS01

Receptor Information >5iwa Chain H (length=138) Species: 300852 (Thermus thermophilus HB8) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure] MLTDPIADMLTRIRNATRVYKESTDVPASRFKEEILRILAREGFIKGYER VDVDGKPYLRVYLKYGPRRQGPDPRPEQVIHHIRRISKPGRRVYVGVKEI PRVRRGLGIAILSTSKGVLTDREARKLGVGGELICEVW

Ligand information >5iwa Chain A (length=1509) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure] aaauuggagaguuugauccuggcucagggugaacgcuggcggcgugccua agacaugcaagucgugcgggccgcgggguuuuacuccguggucagcggcg gacgggugaguaacgcgugggugaccuacccggaagagggggacaacccg gggaaacucgggcuaaucccccauguggacccgccccuuggggugugucc aaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguugg ugggguaauggcccaccaaggcgacgacggguagccggucugagaggaug gccggccacaggggcacugagacacgggccccacuccuacgggaggcagc aguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuu ggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaaccc ccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgug ccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugg gcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacgg cucaaccgugggggagcgugggauacgcucaggcuagacggugggagagg gugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaac gccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaa agcguggggagcaaaccggauuagauacccggguaguccacgcccuaaac gaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaa gcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauuga cgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcg aagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccugg ggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucag cucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgc cguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaa agcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccu gggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaa cggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaa cccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccg cggugaauacguucccgggccuuguacacaccgcccgucacgccauggga gcgggcucuacccgaagucgccgggagccuacgggcaggcgccgagggua gggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggug cggcuggau ........<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<. .<<<.<<<..<<<..<<.<<<<<<<<<<<...>>>>>>>>>>>.>>>>>. .....<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<< <......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>> >..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<< <<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>. ..>>>>.>>.<<<<<.<.........>>>>>>.<<<<<..>>>>>...>> >>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>.. <<<<......<<<<....>>>>.....>>>>....<<<<<......<.<< <<.....>>>>..>.......>>>>>......<<<<<(((...<<<<<.. ...<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........< <<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<< .....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<< <<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>.... .......<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>... .<<<<<<...<<...<<<<.........>>>>...>>>>>>>>....... ...<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>..... >>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<< <<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>> ..........<<<<<<<......<<<<<<<<..<<<<<<<....>>>>>> >...<<<<....>>>>..>>>>>>>>.<<<.<<<..<<<<<<.......< <<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.< <<<<<<..<<<..<<<.....>>>>>>...>>>>>>>.....<<<<<... .>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>> >>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<.... >>>>..>>....>>>.....>>>>>>>......<....<<<<<<<..... ...>>>>>>>....>.....>>>>>>....<<<<<<<..........>>> >>>>......>>...>>>>>>>>>>.>>....<..<<...<<<<.<<... <<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>> >>>>>>>>...>>.>>>>....>>...>.....<<<<<<<<<....>>>> >>>>>....

Receptor-Ligand Complex Structure Global view Local view Structure summary [Spin on] [Spin off] [Reset] [High quality] [Low quality] [White background] [Black background] [Spin on] [Spin off] [Reset] [High quality] [Low quality] [White background] [Black background] PDB 5iwa Inhibition of translation initiation complex formation by GE81112 unravels a 16S rRNA structural switch involved in P-site decoding. Resolution 3.5 Å Binding residue (original residue number in PDB) M1 T3 D8 T11 R12 R14 N15 V19 K21 S29 R30 K56 R75 K88 P89 G90 R91 Y94 G96 V97 R105 S113 T114 S115 G128 G130 E132 Binding residue (residue number reindexed from 1) M1 T3 D8 T11 R12 R14 N15 V19 K21 S29 R30 K56 R75 K88 P89 G90 R91 Y94 G96 V97 R105 S113 T114 S115 G128 G130 E132

Enzymatic activity Enzyme Commision number ?

Gene Ontology Molecular Function GO:0003735 structural constituent of ribosome GO:0019843 rRNA binding

	Biological Process
GO:0006412	translation

	Cellular Component
GO:0005737	cytoplasm
GO:0005840	ribosome
GO:0022627	cytosolic small ribosomal subunit
GO:1990904	ribonucleoprotein complex

View graph for Molecular Function

View graph for Biological Process

View graph for Cellular Component