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Structure of PDB 5iwa Chain J Binding Site BS01

Receptor Information >5iwa Chain J (length=99) Species: 300852 (Thermus thermophilus HB8) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure] KIRIKLRGFDHKTLDASAQKIVEAARRSGAQVSGPIPLPTRVRRFTVIRG PFKHKDSREHFELRTHNRLVDIINPNRKTIEQLMTLDLPTGVEIEIKTV

Ligand information >5iwa Chain A (length=1509) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure] aaauuggagaguuugauccuggcucagggugaacgcuggcggcgugccua agacaugcaagucgugcgggccgcgggguuuuacuccguggucagcggcg gacgggugaguaacgcgugggugaccuacccggaagagggggacaacccg gggaaacucgggcuaaucccccauguggacccgccccuuggggugugucc aaagggcuuugcccgcuuccggaugggcccgcgucccaucagcuaguugg ugggguaauggcccaccaaggcgacgacggguagccggucugagaggaug gccggccacaggggcacugagacacgggccccacuccuacgggaggcagc aguuaggaaucuuccgcaaugggcgcaagccugacggagcgacgccgcuu ggaggaagaagcccuucgggguguaaacuccugaacccgggacgaaaccc ccgacgaggggacugacgguaccgggguaauagcgccggccaacuccgug ccagcagccgcgguaauacggagggcgcgagcguuacccggauucacugg gcguaaagggcguguaggcggccuggggcgucccaugugaaagaccacgg cucaaccgugggggagcgugggauacgcucaggcuagacggugggagagg gugguggaauucccggaguagcggugaaaugcgcagauaccgggaggaac gccgauggcgaaggcagccaccugguccacccgugacgcugaggcgcgaa agcguggggagcaaaccggauuagauacccggguaguccacgcccuaaac gaugcgcgcuaggucucugggucuccugggggccgaagcuaacgcguuaa gcgcgccgccuggggaguacggccgcaaggcugaaacucaaaggaauuga cgggggcccgcacaagcgguggagcaugugguuuaauucgaagcaacgcg aagaaccuuaccaggccuugacaugcuagggaacccgggugaaagccugg ggugccccgcgaggggagcccuagcacaggugcugcauggccgucgucag cucgugccgugagguguuggguuaagucccgcaacgagcgcaacccccgc cguuaguugccagcgguucggccgggcacucuaacgggacugcccgcgaa agcgggaggaaggaggggacgacgucuggucagcauggcccuuacggccu gggcgacacacgugcuacaaugcccacuacaaagcgaugccacccggcaa cggggagcuaaucgcaaaaaggugggcccaguucggauuggggucugcaa cccgaccccaugaagccggaaucgcuaguaaucgcggaucagccaugccg cggugaauacguucccgggccuuguacacaccgcccgucacgccauggga gcgggcucuacccgaagucgccgggagccuacgggcaggcgccgagggua gggcccgugacuggggcgaagucguaacaagguagcuguaccggaaggug cggcuggau ........<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<. .<<<.<<<..<<<..<<.<<<<<<<<<<<...>>>>>>>>>>>.>>>>>. .....<<.......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<< <......>>>>>.....>>>>>...<<<<<.<<<<<....>>>>>.>>>> >..<<<<...>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<< <<<<.......>>>>>>>>>>>......>>>..<<<<<<<<....>>>>. ..>>>>.>>.<<<<<.<.........>>>>>>.<<<<<..>>>>>...>> >>>>>........<<<....<<<<....>>>>..>>>..>>.>>>>>>.. <<<<......<<<<....>>>>.....>>>>....<<<<<......<.<< <<.....>>>>..>.......>>>>>......<<<<<(((...<<<<<.. ...<<.)))>>.......>>>>>>>>>>..>>>>>>>>>..........< <<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<< .....>>>>>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<< <<<<<....<<<<<<<.<..<<<......>>>.....>.>>>>>>>.... .......<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>... .<<<<<<...<<...<<<<.........>>>>...>>>>>>>>....... ...<<<<<<..<<<<<<<<<<...>>>>>>>>>>...<<..))>>..... >>>>>>.>>>.<<<......<<<<....>>>>....>>>..)))).]<<< <<.<<<<<<<.<<.<<<<<<..<<<<<<<<<<......<<........>> ..........<<<<<<<......<<<<<<<<..<<<<<<<....>>>>>> >...<<<<....>>>>..>>>>>>>>.<<<.<<<..<<<<<<.......< <<<<<<<<....>>>..<<<<......>>>>..>>>>>>.....<<<<.< <<<<<<..<<<..<<<.....>>>>>>...>>>>>>>.....<<<<<... .>>>>>........>>>>.........>>>...>>>>>>>>>...>>>>> >>...>>.>>>>>>>>.....<<<<<<<.....<<<..<<..<<<<.... >>>>..>>....>>>.....>>>>>>>......<....<<<<<<<..... ...>>>>>>>....>.....>>>>>>....<<<<<<<..........>>> >>>>......>>...>>>>>>>>>>.>>....<..<<...<<<<.<<... <<<<<<<<<<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>> >>>>>>>>...>>.>>>>....>>...>.....<<<<<<<<<....>>>> >>>>>....

Receptor-Ligand Complex Structure Global view Local view Structure summary [Spin on] [Spin off] [Reset] [High quality] [Low quality] [White background] [Black background] [Spin on] [Spin off] [Reset] [High quality] [Low quality] [White background] [Black background] PDB 5iwa Inhibition of translation initiation complex formation by GE81112 unravels a 16S rRNA structural switch involved in P-site decoding. Resolution 3.5 Å Binding residue (original residue number in PDB) R5 K7 H13 D17 S35 G36 P37 I38 P39 L40 P41 T42 R43 V44 R51 G52 P53 F54 K55 H56 K57 S59 R60 H62 H68 R70 L71 Binding residue (residue number reindexed from 1) R3 K5 H11 D15 S33 G34 P35 I36 P37 L38 P39 T40 R41 V42 R49 G50 P51 F52 K53 H54 K55 S57 R58 H60 H66 R68 L69

Enzymatic activity Enzyme Commision number ?

Gene Ontology Molecular Function GO:0000049 tRNA binding GO:0003723 RNA binding GO:0003735 structural constituent of ribosome GO:0019843 rRNA binding

	Biological Process
GO:0006412	translation

	Cellular Component
GO:0005840	ribosome
GO:0015935	small ribosomal subunit
GO:1990904	ribonucleoprotein complex

View graph for Molecular Function

View graph for Biological Process

View graph for Cellular Component