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Structure of PDB 6z6j Chain LJ Binding Site BS01

Receptor Information >6z6j Chain LJ (length=169) Species: 559292 (Saccharomyces cerevisiae S288C) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure] QNPMRDLKIEKLVLNISVGESGDRLTRASKVLEQLSGQTPVQSKARYTVR TFGIRRNEKIAVHVTVRGPKAEEILERGLKVKEYQLRDRNFSATGNFGFG IDEHIDLGIKYDPSIGIFGMDFYVVMNRPGARVTRRKRCKGTVGNSHKTT KEDTVSWFKQKYDADVLDK

Ligand information >6z6j Chain C1 (length=3127) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure] uugaccucaaaucagguaggaguacccgcugaacuuaagcauaucaauaa gcggaggaaaagaaaccaaccgggauugccuuaguaacggcgagugaagc ggcaaaagcucaaauuugaaaucugguaccuucggugcccgaguuguaau uuggagagggcaacuuuggggccguuccuugucuauguuccuuggaacag gacgucauagagggugagaaucccguguggcgaggagugcgguucuuugu aaagugccuucgaagagucgaguuguuugggaaugcagcucuaagugggu gguaaauuccaucuaaagcuaaauauuggcgagagaccgauagcgaacaa guacagugauggaaagaugaaaagaacuuugaaaagagagugaaaaagua cgugaaauuguugaaagggaagggcauuugaucagacaggccagcaucag uuuugguggcaggauaaauccauaggaauguagcuugccucgguaaguau uauagccugugggaauacugccagcugggacugaggacugcgacguaagu caaggaugcuggcauaaugguuauaugccgcccgucuugaaacacggacc aaggagucuaacgucuaugcgaguguuuggguguaaaacccauacgcgua augaaagugaacguagguuggggccucgcaagaggugcacaaucgaccga uccugaugucuucggauggauuugaguaagagcauagcuguugggacccg aaagauggugaacuaugccugaauagggugaagccagaggaaacucuggu ggaggcucguagcgguucugacgugcaaaucgaucgucgaauuuggguau aggggcgaaagacuaaucgaaccaucuaguagcugguuccugccgaaguu ucccucaggauagcagaagcucguaucaguuuuaugagguaaagcgaaug auuagagguuccggggucgaaaugaccuugaccuauucucaaacuuuaaa uauguaagaaguccuuguuacuuaauugaacguggacauuugaaugaaga gcuuuuagugggccauuuuugguaagcagaacuggcgaugcgggaugaac cgaacguagaguuaaggugccggaauacacgcucaucagacaccacaaaa gguguuaguucaucuagacagccggacgguggccauggaagucggaaucc gcuaaggaguguguaacaacucaccggccgaaugaacuagcccugaaaau ggauggcgcucaagcguguuaccuauacucuaccgucaggguuaugaugc ccugacgaguaggcaggcguggaggucagugacgaagccuagaccguaag gucgggucgaacggccucuagugcagaucuuggugguaguagcaaauauu caaaugagaacuuugaagacugaaguggggaaagguuccacgucaacagc aguuggacguggguuagucgauccuaagagauggggaagcuccguuucaa aggccugcaggccaccaucgaaagggaauccgguuaagauuccggaaccu ggauauggauucuucacgguaacguaacugaauguggagacgucggcgcg agcccugggaggaguuaucuuuucuucuuaacagcuuaucaccccggaau ugguuuauccggagauggggucuuauggcuggaagaggccagcaccuuug cuggcuccggugcgcuugugacggcccgugaaaauccacaggaaggaaua guuuucaugccaggucguacugauaaccgcagcaggucuccaaggugaac agccucuaguugauagaauaauguagauaagggaagucggcaaaauagau ccguaacuucgggauaaggauuggcucuaagggucggacgaucaacuuag aacugguacggacaaggggaaucugacugucuaauuaaaacauagcauug cgauggucagaaagugauguugacgcaaugugauuucugcccagugcucu gaaugucaaagugaagaaauucaaccaagcgcggguaaacggcgggagua acuaugacucucuuaagguagccaaaugccucgucaucuaauuagugacg cgcaugaauggauuaacgagauucccacugucccuaucuacuaucuagcg aaaccacagccaagggaacgggcuuggcagaaucagcggggaaagaagac ccuguugagcuugacucuaguuugacauugugaagaguuucuuuacuuau ucaaugaagcggagcuggaauucauuuuccacguucuagcauucaagguc ccauucggggcugauccggguugaagacauugucagguggggaguuuggc uggggcggcacaucuguuaaacgauaacgcagauguccuaaggggggcuc auggagaacagaaaucuccaguagaacaaaaggguaaaagcccccuugau uuugauuuucagugugaauacaaaccaugaaaguguggccuaucgauccu uuagucccucggaauuugaggcuagaggugccagaaaaguuaccacaggg auaacuggcuuguggcagucaagcguucauagcgacauugcuuuuugauu cuucgaugucggcucuuccuaucauaccgaagcagaauucgguaagcguu ggauuguucacccacuaauagggaacgugagcuggguuuagaccgucgug agacagguuaguuuuacccuacugaugaauguuaccgcaauaguaauuga acuuaguacgagaggaacaguucauucggauaauugguuuuugcggcugu cugaucaggcauugccgcgaagcuaccauccgcuggauuauggcugaacg ccucuaagucagaauccaugcuagaacgcggugauuuugcuccacacaau auagauggauacgaauaaggcguccuuguggcgucgcugaaccauagcag gcuagcaacggugcacuuggcggaaaggccuugggugcuugcuggcgaau ugcaaugucauuuugcguggggauaaaucauuuguauacgacuuagaugu acaacgggguauuguaagcaguagaguagccuuguuguuacgaucugcug agauuaagccuuuguugucugauuugu ........................<<<<<<.....<......>......> >>>>.>.........<<....>>..<<<<<......<<.....>>..... >>>>>..[[[...........<<.<<<<<<...>>>>>>.>>........ .....<<<<<<.<<<<<<<<<<<<<<<<<<<<<<....<<<<......>> >>.(.......<<<......)>>>..>.>>>>>>>>..>>>>>>>>.... >>>>>>>>>>>........<<<<<<<........>>>>>>>.....(((( (..<<<<<<)))))..]]]............................... ...<<....>>...............<<<<....>>>>............ ......................<<<<<.<<<<<......<<<<<<<<<<< <<<<<<<<<<<<.....<<<<<<<<<......<<<<<<....>>>>>>.. .....>>>>>>>.>.>.>>>>>.>>>>>>>>>>........<<<....>> >....>>>>>>>>.....>>>>>.>>>>>..<<<<........>>>><<< <<<....<<<<<<.<<<<<<..<<<...<<<<.....>>>>...>>>... <<....>>.......<<<<<..<<<<<....>>>>>...>>>>>.<<<<< <<<...<<....>>...>>>.>>>.>>....>>>>>>.>>>>>>..<<.< ..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>> .....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>> ...<<.......>>......>>>>>>...>..>.>>..<<<<<<....<. <<<....>>>.><<<<<<<<<<...<<<.<<<<<<<.....<<<....<< <....<<<<...<<<<<<.....>>>>>>.>>>>....>>>..>.>>... ..>>>>>...<<<<.<<<<.<......>>>>>.>>>>.....>>>>>.>> >>>>>>.>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......> >>...<<<<<<<..<<<<(((.....<<<<<<......<..........< <<.<<<<<<<<<<.......<<<<<.<<....<<.........>>....> >.........<<......>>...>>>>>...>>>>>>>>>>>>>...... ....))).>....>>>>>>.>>>>..>>>>>>><<<<<<<<<......>> >>>>>>>....>>>>>><.<<<<<<<<.<<......<<<<.<<<<....> >>>>>>>...>>>>>>>>>>..>.....>>>>>><<.....<<.....<< <<<<.......>>>>>><<<<.....<<<<<.<<...<<<<<<...<<.. ...>>.>>>>>>....((<<<<<<...<<....<<<....>>>....... .<<.<<...>>>>....>>....>>...<<<<<........>>>>>))<< <<.<<<<<<<.....<<<....>>>...<...<<<<<<...<<<<.<<<< <<<.<<<<<<<<<<..{{{..>>>>>><...<<<<<....<<<<<<.... <<<.....>>>....>>>>>>.....>>>>>....><<<<<<<<....>> >>>>>>>>>>...>>>>>>>.>>>>.........>>>>>>...>...... >>>..>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<.... .>>>>..>>>>..<<<<.....<<<<<<<.<<.........<.....<<< <<....<<..>>.....>>>>><<.<<<<<<<<<<<..>>>>>..>>>>> >.>>............<<<<<<<<<..<<<.........>>>..<<<<<< <....<<<<.....>>>>......>>>>>>>...<<..<<<..<<<<<<. ...<<<....<<<<<....>>>>.>...>>>.>>>>..>>>>><<<<<<. ......>>>>>>........<...........<<<<<.......>>>>>. ....>.....>>....>>.>>>>>>>..>..>>.>>>>>>>..>>>>>>. ...>>....<<<<<........>>>>>....[[[[[..{{{.{{...... [[[[.{{[[[[..<<<<<.<<<<<<<<..<<<<<<<...>>>>>>>...< <<<<.....<<<<..<<<..........>>>...............<<<< <<....>>>>>>..>>>>..>>>>>.....>>>>>>>>..>>>>>...<< <.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<.. .<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>...< <<.<<<<<.......>>>>.>>>>.<<<....>>>.>>))).......(( ((((..((((.>>>>>>))))))))))..........]]]]..}}]]]]. ......<<.<.<.<<<<<<...<<.......>>...>>>>>>...>>.>. >.......<<<<<.<<<<<<..<.<<<<<<<......>>>>>>>...>.< <<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<... .>>>.>>>>....}}..}}}.]]]]]....<<<<<<<<..<<<<.<.<<< <<<...............>>>>>>.><<<<<...<<<<....<<<<<<<< <<}}}.>>>>>..>>>>>...>>>>..>>>>>.<<<<...<<<<<..... ......>>>>>...>>>>.>>>>....>>>>>>>>....<<<<<<.<<<. <<....<<..........<<<<<<.....>>>>>>......>>....... <<<<<<...<<<<<.<..<<<......>>>..>.>>>>>.>>>>>>.... .........>>.>>>.>>>>>>..<<<<<.<.............>..... <<<<<<<<<.<<<....<<<<....<<<<<......>>>>>...>>>>.. .>>>....>>>>.>>>>>..>>>>>..

Receptor-Ligand Complex Structure Global view Local view Structure summary [Spin on] [Spin off] [Reset] [High quality] [Low quality] [White background] [Black background] [Spin on] [Spin off] [Reset] [High quality] [Low quality] [White background] [Black background] PDB 6z6j Structure and function of yeast Lso2 and human CCDC124 bound to hibernating ribosomes. Resolution 3.4 Å Binding residue (original residue number in PDB) K16 N20 S22 S48 A50 R51 Y52 F57 I59 N95 S97 A98 T99 N101 F104 D107 G124 D126 Y128 R140 K142 Binding residue (residue number reindexed from 1) K11 N15 S17 S43 A45 R46 Y47 F52 I54 N90 S92 A93 T94 N96 F99 D102 G119 D121 Y123 R135 K137

Enzymatic activity Enzyme Commision number ?

Gene Ontology Molecular Function GO:0003723 RNA binding GO:0003735 structural constituent of ribosome GO:0019843 rRNA binding

	Biological Process
GO:0000027	ribosomal large subunit assembly
GO:0002181	cytoplasmic translation
GO:0006412	translation

	Cellular Component
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005840	ribosome
GO:0022625	cytosolic large ribosomal subunit
GO:1990904	ribonucleoprotein complex

View graph for Molecular Function

View graph for Biological Process

View graph for Cellular Component