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Structure of PDB 6bz7 Chain RH Binding Site BS01

Receptor Information >6bz7 Chain RH (length=174) Species: 300852 (Thermus thermophilus HB8) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure] SRIGRLPIPVPKGVSVEVAPGRVKVKGPKGELEVPVSPEMRVVVEEGVVR VERPSDERRHKSLHGLTRTLIANAVKGVSEGYSKELLIKGIGYRARLVGR ALELTVGFSHPVVVEPPEGITFEVPEPTRVRVSGIDKQKVGQVAANIRAI RKPSAYHEKGIYYAGEPVRLKPGK

Ligand information >6bz7 Chain RA (length=2882) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure] agaugguaagggcccacgguggaugccucggcacccgagccgaugaagga cguggcuaccugcgauaagccagggggagccgguagcgggcguggauccc uggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgc ugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagag gaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccu aaaccguccggcuuguccgggcggggucguggggcccucggacaccgaau ccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagc cccguaggcgaaagguggggggauaggugaggguacccgaguaccccgug guucguggagccaugggggaaucugggcggaccaccgccuaaggcuaagu acuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaaga accccgggaggggagugaaauagagccugaaaccgugggcuuacaagcag ucacggccccgcaagggguuguggcgugccuauugaagcaugagccggcg acucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaa ccgaguccgaacagggcgcaagcgcaaaguccgcggccguggacccgaaa ccgggcgagcuagcccuggccagggugaagcuggggugagacccagugga ggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuagga gugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuu uagggucagccucaggcgcugacuggggccuguagagcacugauagggcu agggggcccaccagccuaccaaacccugucaaacuccgaagggucccagg uggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgg gaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaa aggauguggcgccgcgaagacagccaggagguuggcuuagaagcagccau ccuuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaa augaucggggcuuaagcccagcgccgaagcugcgggucugggggaugacc ccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagg gcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaaga gggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucg ucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccga agggcagccgguuaauauuccggcccuucccgcaggugcgauggggggac gcucuaggcuagggggaccggagccauggacgagcccggccagaagcgca gggugggagguaggcaaauccgccucccaacaagcucugcguggugggga agcccguacgggugacaaccccccgaagccagggagccaagaaaagccuc uaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcggg ugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaa guuggccccguaacuucgggagaaggggugcucccuggggugaugagccc cggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagc ucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugc cggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaac ggcggccguaacuauaacgguccuaagguagcgaaauuccuugucgggua aguuccgaccugcacgaaaagcguaacgaccggagcgcugucucggcgag ggacccggugaaauugaacuggccgugaagaugcggccuacccguggcag gacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggu cgcgccugcguaggauaggugggagccugugaacccccgccuccgggugg gggggaggcgccggugaaauaccacccuggcgcggcugggggccuaaccc ucggauggggggacagcgcuuggcgggcaguuugacuggggcggucgccu ccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaau ccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaag ccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaa gggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucu cccccgagcguccacagcggcggggagguuuggcaccucgaugucggcuc gucgcauccuggggcugaagaaggucccaaggguugggcuguucgcccau uaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucuc uauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgaga ggaccggaagggacgcaccucugguuucccagcugucccuccaggggcau aagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcg ggaagcccgccccaagaugaggccucccacggcgucaagccgguaaggac ccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcg uugagccgaccggucccaaucguccgaggucu <<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<< <<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>> >>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<< .>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>..... ....<<....>>...<<<<<.....<<.....>>....>>>>>...<<<. ...<<<<<<<<.....>>>>>>>>......<<<<<<<<<....<<<...< <<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....)) >>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<< <<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>..... .>>.>>>>>>.>>...............<<....>>....>>........ .<<<<....>>>>..................>>>>>>>>>>>.......< <<<<<<<<<<....>>>>>>>>>>>...<.<........>.>.<<<<<<. ...<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<.... >>..<<<<.....>>>>....<..>...>>>>>>>>>>>>>..<<.<..< <<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>... ..>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>...< <<.....>>>......>>>>>>...>..>.>>..<<<<<<....<<<<<. ...>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<.. .<<<<<<......>>>>.>>...>>>>>>>>..>>.>...>>>>>>>>>. ....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<< ......>>>...<<<<.<<<...<<<(((.....<<<<<<.......... .<<..<<<<<<<<<........<<<<<.<<...<<<<.......>>>>.. .>>.........<<......>>...>>>>>....>>>>>>>>>.>>.... ......)))......>>>>>>.>>>...>>>>>>><<<<<<<<.....>> >>>>>>....>>>>>>..<<<<<...<<<......<<<<<.<<<....>> >>>>>>...>>>..>>>>>........>>>>>><......<<.....<<< <<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.... .>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>.. .>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<.... <<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<< <<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><.. .<<<<....>>>>.....>>>>>>...>>>..>>>>>.........>>>> ...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<< <<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<. ....<<<<<.....<..>......>>>>><<<<<<<<<<<<.....>>>> >>>>>>>>............<<<<<<<<<..<<<.........>>>..<< <<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<< <<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>> >>><<<<<<.......>>>>>>........<...........<<<<<<.. ...>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>> >>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.< <<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<< <<<<<<...........<<<<<..<<<......<<<<<<<<....>>>>> >>>...>>>............>>>>>..>>>>>>>>>>>>>>>>...<<< <<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<< <<...........>>>>>>..<<...<<<<<<<...<<<<<<.......> >>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......> >>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..)))).. >>>>>>>>>.............>>>>..>>>>>>.......<<<<.<<<< <<<<...<<.......>>...>>>>>>>..>>>>.>.......<<<<<.< <<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>. ....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>...... ..>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<.......... .....>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>. ..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>> >....>>>.>>>>.......>>>>>>>...<<<.....>>>.....<<<< <<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>> >...>>>..>>>>>.>>>...>>>>....>>>

Receptor-Ligand Complex Structure Global view Local view Structure summary [Spin on] [Spin off] [Reset] [High quality] [Low quality] [White background] [Black background] [Spin on] [Spin off] [Reset] [High quality] [Low quality] [White background] [Black background] PDB 6bz7 Ribosomal ambiguity (ram) mutations promote the open (off) to closed (on) transition and thereby increase miscoding. Resolution 3.68 Å Binding residue (original residue number in PDB) S2 R3 I4 R59 S63 L67 T70 S110 K138 Q139 Q143 R152 Y157 H158 K172 K175 Binding residue (residue number reindexed from 1) S1 R2 I3 R58 S62 L66 T69 S109 K137 Q138 Q142 R151 Y156 H157 K171 K174

Enzymatic activity Enzyme Commision number ?

Gene Ontology Molecular Function GO:0003735 structural constituent of ribosome GO:0019843 rRNA binding

	Biological Process
GO:0002181	cytoplasmic translation
GO:0006412	translation

	Cellular Component
GO:0005840	ribosome
GO:0022625	cytosolic large ribosomal subunit
GO:1990904	ribonucleoprotein complex

View graph for Molecular Function

View graph for Biological Process

View graph for Cellular Component