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Structure of PDB 6bz7 Chain RY Binding Site BS01

Receptor Information >6bz7 Chain RY (length=107) Species: 300852 (Thermus thermophilus HB8) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure] MRVKMHVKKGDTVLVASGKYKGRVGKVKEVLPKKYAVIVEGVNIVKKAVR VSPKYPQGGFIEKEAPLHASKVRPICPACGKPTRVRKKFLENGKKIRVCA KCGGALD

Ligand information >6bz7 Chain RA (length=2882) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure] agaugguaagggcccacgguggaugccucggcacccgagccgaugaagga cguggcuaccugcgauaagccagggggagccgguagcgggcguggauccc uggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgc ugcgcggggggaaccuggggaacugaaacaucucaguacccagaggagag gaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagccu aaaccguccggcuuguccgggcggggucguggggcccucggacaccgaau ccccagccuagccgaagcuguugggaagcagcgccagagagggugaaagc cccguaggcgaaagguggggggauaggugaggguacccgaguaccccgug guucguggagccaugggggaaucugggcggaccaccgccuaaggcuaagu acuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaaga accccgggaggggagugaaauagagccugaaaccgugggcuuacaagcag ucacggccccgcaagggguuguggcgugccuauugaagcaugagccggcg acucacggucgugggcgagcuuaagccguugaggcggaggcguagggaaa ccgaguccgaacagggcgcaagcgcaaaguccgcggccguggacccgaaa ccgggcgagcuagcccuggccagggugaagcuggggugagacccagugga ggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuagga gugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuu uagggucagccucaggcgcugacuggggccuguagagcacugauagggcu agggggcccaccagccuaccaaacccugucaaacuccgaagggucccagg uggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcgg gaacaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaa aggauguggcgccgcgaagacagccaggagguuggcuuagaagcagccau ccuuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaaa augaucggggcuuaagcccagcgccgaagcugcgggucugggggaugacc ccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgagg gcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaaga gggugagaaucccucucgccguaagcccaaggguuccuacgcaauggucg ucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccga agggcagccgguuaauauuccggcccuucccgcaggugcgauggggggac gcucuaggcuagggggaccggagccauggacgagcccggccagaagcgca gggugggagguaggcaaauccgccucccaacaagcucugcguggugggga agcccguacgggugacaaccccccgaagccagggagccaagaaaagccuc uaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcggg ugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugcaa guuggccccguaacuucgggagaaggggugcucccuggggugaugagccc cggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacagc ucucugcgaacucguaagaggagguauagggagcgacgcuugcccggugc cggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaac ggcggccguaacuauaacgguccuaagguagcgaaauuccuugucgggua aguuccgaccugcacgaaaagcguaacgaccggagcgcugucucggcgag ggacccggugaaauugaacuggccgugaagaugcggccuacccguggcag gacgaaaagaccccguggagcuuuacugcagccugguguuggcucuuggu cgcgccugcguaggauaggugggagccugugaacccccgccuccgggugg gggggaggcgccggugaaauaccacccuggcgcggcugggggccuaaccc ucggauggggggacagcgcuuggcgggcaguuugacuggggcggucgccu ccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaau ccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaag ccgagcaggggcgaaagccgggccuagugaaccgguggucccguguggaa gggccaucgaucaacggauaaaaguuaccccggggauaacaggcugaucu cccccgagcguccacagcggcggggagguuuggcaccucgaugucggcuc gucgcauccuggggcugaagaaggucccaaggguugggcuguucgcccau uaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucuc uauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgaga ggaccggaagggacgcaccucugguuucccagcugucccuccaggggcau aagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagcg ggaagcccgccccaagaugaggccucccacggcgucaagccgguaaggac ccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggcg uugagccgaccggucccaaucguccgaggucu <<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<< <<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>> >>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<< .>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>..... ....<<....>>...<<<<<.....<<.....>>....>>>>>...<<<. ...<<<<<<<<.....>>>>>>>>......<<<<<<<<<....<<<...< <<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....)) >>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<<< <<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>..... .>>.>>>>>>.>>...............<<....>>....>>........ .<<<<....>>>>..................>>>>>>>>>>>.......< <<<<<<<<<<....>>>>>>>>>>>...<.<........>.>.<<<<<<. ...<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<.... >>..<<<<.....>>>>....<..>...>>>>>>>>>>>>>..<<.<..< <<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>... ..>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>...< <<.....>>>......>>>>>>...>..>.>>..<<<<<<....<<<<<. ...>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<.. .<<<<<<......>>>>.>>...>>>>>>>>..>>.>...>>>>>>>>>. ....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<< ......>>>...<<<<.<<<...<<<(((.....<<<<<<.......... .<<..<<<<<<<<<........<<<<<.<<...<<<<.......>>>>.. .>>.........<<......>>...>>>>>....>>>>>>>>>.>>.... ......)))......>>>>>>.>>>...>>>>>>><<<<<<<<.....>> >>>>>>....>>>>>>..<<<<<...<<<......<<<<<.<<<....>> >>>>>>...>>>..>>>>>........>>>>>><......<<.....<<< <<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.... .>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>.. .>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<.... <<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<< <<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><.. .<<<<....>>>>.....>>>>>>...>>>..>>>>>.........>>>> ...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<< <<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<. ....<<<<<.....<..>......>>>>><<<<<<<<<<<<.....>>>> >>>>>>>>............<<<<<<<<<..<<<.........>>>..<< <<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<< <<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>> >>><<<<<<.......>>>>>>........<...........<<<<<<.. ...>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>> >>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.< <<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<<< <<<<<<...........<<<<<..<<<......<<<<<<<<....>>>>> >>>...>>>............>>>>>..>>>>>>>>>>>>>>>>...<<< <<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<< <<...........>>>>>>..<<...<<<<<<<...<<<<<<.......> >>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<......> >>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..)))).. >>>>>>>>>.............>>>>..>>>>>>.......<<<<.<<<< <<<<...<<.......>>...>>>>>>>..>>>>.>.......<<<<<.< <<<<<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>. ....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>...... ..>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<.......... .....>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>. ..>>>>>...>>>>.>>>>>...<<<....<<<<<...........>>>> >....>>>.>>>>.......>>>>>>>...<<<.....>>>.....<<<< <<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>>> >...>>>..>>>>>.>>>...>>>>....>>>

Receptor-Ligand Complex Structure Global view Local view Structure summary [Spin on] [Spin off] [Reset] [High quality] [Low quality] [White background] [Black background] [Spin on] [Spin off] [Reset] [High quality] [Low quality] [White background] [Black background] PDB 6bz7 Ribosomal ambiguity (ram) mutations promote the open (off) to closed (on) transition and thereby increase miscoding. Resolution 3.68 Å Binding residue (original residue number in PDB) M1 R2 K4 H6 K8 G18 K19 K21 V30 P32 Y35 K47 A48 V49 G59 F60 S70 K71 R73 R84 R86 K87 K95 Binding residue (residue number reindexed from 1) M1 R2 K4 H6 K8 G18 K19 K21 V30 P32 Y35 K47 A48 V49 G59 F60 S70 K71 R73 R84 R86 K87 K95

Enzymatic activity Enzyme Commision number ?

Gene Ontology Molecular Function GO:0003723 RNA binding GO:0003735 structural constituent of ribosome GO:0019843 rRNA binding

	Biological Process
GO:0006412	translation

	Cellular Component
GO:0005840	ribosome
GO:1990904	ribonucleoprotein complex

View graph for Molecular Function

View graph for Biological Process

View graph for Cellular Component