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Structure of PDB 7azo Chain S8B Binding Site BS01

Receptor Information >7azo Chain S8B (length=138) Species: 300852 (Thermus thermophilus HB8) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure] MLTDPIADMLTRIRNATRVYKESTDVPASRFKEEILRILAREGFIKGYER VDVDGKPYLRVYLKYGPRRQGPDPRPEQVIHHIRRISKPGRRVYVGVKEI PRVRRGLGIAILSTSKGVLTDREARKLGVGGELICEVW

Ligand information >7azo Chain 16SB (length=1508) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure] ggagaguuugauccuggcucagggugaacgcuggcggcgugccuaagaca ugcaagucgugcgggccgcgggguacuccguggucagcggcggacgggug aguaacgcgugggugaccuacccggaagagggggacaacccggggaaacu cgggcuaaucccccauguggacccgccccuugggguguguccaaagggcu uugcccgcuuccggaugggcccgcgucccaucagcuaguuggugggguaa uggcccaccaaggcgacgacggguagccggucugagaggauggccggcca caggggcacugagacacgggccccacuccuacgggaggcagcaguuagga aucuuccgcaaugggcgcaagccugacggagcgacgccgcuuggaggaag aagcccuucgggguguaaacuccugaacccgggacgaaacccccgacgag gggacugacgguaccgggguaauagcgccggccaacuccgugccagcagc cgcgguaauacggagggcgcgagcguuacccggauucacugggcguaaag ggcguguaggcggccuggggcgucccaugugaaagaccacggcucaaccg ugggggagcgugggauacgcucaggcuagacggugggagaggguggugga auucccggaguagcggugaaaugcgcagauaccgggaggaacgccgaugg cgaaggcagccaccugguccacccgugacgcugaggcgcgaaagcguggg gagcaaaccggauuagauacccggguaguccacgcccuaaacgaugcgcg cuaggucucugggucuccugggggccgaagcuaacgcguuaagcgcgccg ccuggggaguacggccgcaaggcugaaacucaaaggaauugacgggggcc cgcacaagcgguggagcaugugguuuaauucgaagcaacgcgaagaaccu uaccaggccuugacaugcuagggaacccgggugaaagccuggggugcccc gcgaggggagcccuagcacaggugcugcauggccgucgucagcucgugcc gugagguguuggguuaagucccgcaacgagcgcaacccccgccguuaguu gccagcgguucggccgggcacucuaacgggacugcccgcgaaagcgggag gaaggaggggacgacgucuggucagcauggcccuuacggccugggcgaca cacgugcuacaaugcccacuacaaagcgaugccacccggcaacggggagc uaaucgcaaaaaggugggcccaguucggauuggggucugcaacccgaccc caugaagccggaaucgcuaguaaucgcggaucagccaugccgcggugaau acguucccgggccuuguacacaccgcccgucacgccaugggagcgggcuc uacccgaagucgccgggagccuacgggcaggcgccgaggguagggcccgu gacuggggcgaagucguaacaagguagcuguaccggaaggugcggcugga ucaccucc ...<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<..<..<<<. <<<..<<<..<<.<<<<<<<<<<..>>>>>>>>>>.>>>>>......<<. ......<<<<<<<<..<<...<<<<<<<.<<<<<....<<<<<......> >>>>.....>>>>>....<<<<.<<<<<....>>>>>.>>>>...<<<<. ..>>>>.>>>>>>>..>>>>>>>>>><<<....<<<..<<<<<<<<.... ...>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.> >.<<<<<.<.........>>>>>>.<<<<<..>>>>>...>>>>>>>... .....<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<.... ..<<<<....>>>>.....>>>>....<<<<<........<<<<.....> >>>..........>>>>>......<<<<<(((...<<<<<.....<<.)) )>>.......>>>>>>>>>>..>>>>>>>>>..........<<<((.... .<<<<...<<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>> >>>....>>>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<... .<<<<<<<.<..<<<......>>>.....>.>>>>>>>...........< <....>>.>>>>>>>..>>>>>.>>>...>>>...>>>>....<<<<<<. ..<<...<<<<.........>>>>...>>>>>>>>..........<<<<< <..<<<<<<<<<<...>>>>>>>>>>...<<..))>>.....>>>>>>.> >>.<<<......<<<<....>>>>....>>>..)))).]<<<<<.<<<<< <<.<<.<<<<<<..<<<<<<<<<<......<<........>>........ ..<<<<<<<......<<<<<<<<..<<<<<<<....>>>>>>>....<<. .....>>...>>>>>>>>.<<<.<<<..<<<<<<.......<<<<<<<<< ....>>>..<<<<......>>>>..>>>>>>.....<<<<.<<<<<<<.. <<...<<<.....>>>.>>...>>>>>>>.....<<<<<....>>>>>.. ......>>>>.........>>>...>>>>>>>>>...>>>>>>>...>>. >>>>>>>>.....<<<<<<<.....<<<..<<..<<<<....>>>>..>> ....>>>.....>>>>>>>......<....<<<<<<<........>>>>> >>....>.....>>>>>>....<<<<<<<..........>>>>>>>.... ..>>...>>>>>>>>>>.>>....<..<<.<.<<<<.<<<..<<<<<<<< <<<<<...<.<<<<....<<<....>>>.>>>>.>..>>>>>>>>>>>>> ..>>>.>>>>..>.>>...>.....<<<<<<<<<....>>>>>>>>>... ........

Receptor-Ligand Complex Structure Global view Local view Structure summary [Spin on] [Spin off] [Reset] [High quality] [Low quality] [White background] [Black background] [Spin on] [Spin off] [Reset] [High quality] [Low quality] [White background] [Black background] PDB 7azo Discovery of natural-product-derived sequanamycins as potent oral anti-tuberculosis agents. Resolution 3.3 Å Binding residue (original residue number in PDB) M1 T3 P5 T11 R12 R14 N15 A28 S29 R30 F31 K56 R75 K88 P89 G90 R91 R92 Y94 G96 V97 K98 S113 T114 S115 G130 E132 Binding residue (residue number reindexed from 1) M1 T3 P5 T11 R12 R14 N15 A28 S29 R30 F31 K56 R75 K88 P89 G90 R91 R92 Y94 G96 V97 K98 S113 T114 S115 G130 E132

Enzymatic activity Enzyme Commision number ?

Gene Ontology Molecular Function GO:0003735 structural constituent of ribosome GO:0019843 rRNA binding

	Biological Process
GO:0006412	translation

	Cellular Component
GO:0005737	cytoplasm
GO:0005840	ribosome
GO:0022627	cytosolic small ribosomal subunit
GO:1990904	ribonucleoprotein complex

View graph for Molecular Function

View graph for Biological Process

View graph for Cellular Component