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Structure of PDB 7mqa Chain SC Binding Site BS01

Receptor Information
>7mqa Chain SC (length=229) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
NVMVEPHRHEGVFICRGKEDALVTKNLVPGESVYGEKRVSISKIEYRAWN
PFRSKLAAAILGGVDQIHIKPGAKVLYLGAASGTTVSHVSDIVGPDGLVY
AVEFSHRSGRDLINLAKKRTNIIPVIEDARHPHKYRMLIAMVDVIFADVA
QPDQTRIVALNAHTFLRNGGHFVISIKANCIDSTASAEAVFASEVKKMQQ
ENMKPQEQLTLEPYERDHAVVVGVYRPPP
Ligand information
>7mqa Chain L2 (length=177) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
gacuauacuuucagggaucauaguguguuacuaaaccacgaggaagagag
guagcguuuucuccugagcgugaagccggcuuucuggcguugcuuggcug
caacugccgucagccauugaugaucguucuucucuccguauuggggagug
agagggagagaacgcggucugaguggu
..................................<<<<<.....<<....
...<<<<<<<<<<<<....<.......<<<<....<<<<<<<<......>
>>>>.>>>...>>>>.........>..<<<<<<<<<<.....>>>>>>.>
>>>>>>>>>>>>>>>...>>..>>>>>
Receptor-Ligand Complex Structure
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PDB7mqa Nucleolar maturation of the human small subunit processome.
Resolution2.7 Å
Binding residue
(original residue number in PDB)
E116 R123
Binding residue
(residue number reindexed from 1)
E31 R38
Enzymatic activity
Enzyme Commision number 2.1.1.-
Gene Ontology
Molecular Function
GO:0001094 TFIID-class transcription factor complex binding
GO:0003723 RNA binding
GO:0005515 protein binding
GO:0008168 methyltransferase activity
GO:0008649 rRNA methyltransferase activity
GO:0051117 ATPase binding
GO:0180021 U6 snRNA 2'-O-ribose methyltransferase activity
GO:1990259 histone H2AQ104 methyltransferase activity
Biological Process
GO:0000494 box C/D sno(s)RNA 3'-end processing
GO:0001649 osteoblast differentiation
GO:0006338 chromatin remodeling
GO:0006364 rRNA processing
GO:0016074 sno(s)RNA metabolic process
GO:0031167 rRNA methylation
GO:0032259 methylation
GO:0042274 ribosomal small subunit biogenesis
GO:0048254 snoRNA localization
Cellular Component
GO:0001650 fibrillar center
GO:0001652 granular component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005730 nucleolus
GO:0015030 Cajal body
GO:0016020 membrane
GO:0031428 box C/D methylation guide snoRNP complex
GO:0032040 small-subunit processome
GO:0070062 extracellular exosome
GO:1990904 ribonucleoprotein complex

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Molecular Function

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Biological Process

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Cellular Component
External links
PDB RCSB:7mqa, PDBe:7mqa, PDBj:7mqa
PDBsum7mqa
PubMed34516797
UniProtP22087|FBRL_HUMAN rRNA 2'-O-methyltransferase fibrillarin (Gene Name=FBL)

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