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Structure of PDB 6bz7 Chain YQ Binding Site BS01

Receptor Information >6bz7 Chain YQ (length=141) Species: 300852 (Thermus thermophilus HB8) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure] MLMPRRMKYRKQQRGRLKGATKGGDYVAFGDYGLVALEPAWITAQQIEAA RVAMVRHFRRGGKIFIRIFPDKPYTKKPLEVRMGKGKGNVEGYVAVVKPG RVMFEVAGVTEEQAMEALRIAGHKLPIKTKIVRRDAYDEAQ

Ligand information >6bz7 Chain YA (length=2883) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure] agaugguaagggcccacgguggaugccucggcacccgagccgaugaagga cguggcuaccugcgauaagccagggggagccgguagcgggcguggauccc uggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgc uugcgcggggggaaccuggggaacugaaacaucucaguacccagaggaga ggaaagagaaaucgacucccugaguagcggcgagcgaaaggggaccagcc uaaaccguccggcuuguccgggcggggucguggggcccucggacaccgaa uccccagccuagccgaagcuguugggaagcagcgccagagagggugaaag ccccguaggcgaaagguggggggauaggugaggguacccgaguaccccgu gguucguggagccaugggggaaucugggcggaccaccgccuaaggcuaag uacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaaaag aaccccgggaggggagugaaauagagccugaaaccgugggcuuacaagca gucacggccccgcaagggguuguggcgugccuauugaagcaugagccggc gacucacggucgugggcgagcuuaagccguugaggcggaggcguagggaa accgaguccgaacagggcgcaagcgcaaaguccgcggccguggacccgaa accgggcgagcuagcccuggccagggugaagcuggggugagacccagugg aggcccgaaccggugggggaugcaaaccccucggaugagcuggggcuagg agugaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacu uuagggucagccucaggcgcugacuggggccuguagagcacugauagggc uagggggcccaccagccuaccaaacccugucaaacuccgaagggucccag guggagccugggagugagggcgcgagcgauaacguccgcguccgagcgcg ggaacaaccgagaccgccagcuaaggcccccaagucugggcuaaguggua aaggauguggcgccgcgaagacagccaggagguuggcuuagaagcagcca uccuuuaaagagugcguaauagcucacuggucgaguggcgccgcgccgaa aaugaucggggcuuaagcccagcgccgaagcugcgggucugggggaugac cccaggcgguaggggagcguucccgaugccgaugaaggccgacccgcgag ggcggcuggagguaagggaagugcgaaugccggcaugaguaacgauaaag agggugagaaucccucucgccguaagcccaaggguuccuacgcaaugguc gucagcguaggguuaggcgggaccuaaggugaagccgaaaggcguagccg aagggcagccgguuaauauuccggcccuucccgcaggugcgaugggggga cgcucuaggcuagggggaccggagccauggacgagcccggccagaagcgc agggugggagguaggcaaauccgccucccaacaagcucugcguggugggg aagcccguacgggugacaaccccccgaagccagggagccaagaaaagccu cuaagcacaaccugcgggaacccguaccgcaaaccgacacaggugggcgg gugcaagagcacucaggcgcgcgggagaacccucgccaaggaacucugca aguuggccccguaacuucgggagaaggggugcucccuggggugaugagcc ccggggagccgcagugaacaggcucuggcgacuguuuaccaaaaacacag cucucugcgaacucguaagaggagguauagggagcgacgcuugcccggug ccggaaggucaaggggaggggugcaagccccgaaccgaagccccggugaa cggcggccguaacuauaacgguccuaagguagcgaaauuccuugucgggu aaguuccgaccugcacgaaaagcguaacgaccggagcgcugucucggcga gggacccggugaaauugaacuggccgugaagaugcggccuacccguggca ggacgaaaagaccccguggagcuuuacugcagccugguguuggcucuugg ucgcgccugcguaggauaggugggagccugugaacccccgccuccgggug ggggggaggcgccggugaaauaccacccuggcgcggcugggggccuaacc cucggauggggggacagcgcuuggcgggcaguuugacuggggcggucgcc uccuaaaagguaacggaggcgcccaaagguccccucaggcgggacggaaa uccgccggagagcgcaaggguagaagggggccugacugcgaggccugcaa gccgagcaggggcgaaagccgggccuagugaaccgguggucccgugugga agggccaucgaucaacggauaaaaguuaccccggggauaacaggcugauc ucccccgagcguccacagcggcggggagguuuggcaccucgaugucggcu cgucgcauccuggggcugaagaaggucccaaggguugggcuguucgccca uuaaagcggcacgcgagcuggguucagaacgucgugagacaguucggucu cuauccgccacgggcgcaggaggcuugaggggggcucuuccuaguacgag aggaccggaagggacgcaccucugguuucccagcugucccuccaggggca uaagcuggguagccaugugcggaagggauaaccgcugaaagcaucuaagc gggaagcccgccccaagaugaggccucccacggcgucaagccgguaagga cccgggaagaccacccgguggaugggccggggguguaagcgccgcgaggc guugagccgaccggucccaaucguccgaggucu <<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<< <<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>> >>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<< ..>>>>>>.>>...<<<<<<.....<......>......>>>>>.>.... .....<<....>>...<<<<<.....<<.....>>....>>>>>...<<< ....<<<<<<<<.....>>>>>>>>......<<<<<<<<<....<<<... <<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<.....) )>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<<<< <<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>.... ..>>.>>>>>>.>>...............<<....>>....>>....... ..<<<<....>>>>..................>>>>>>>>>>>....... <<<<<<<<<<<....>>>>>>>>>>>...<.<........>.>.<<<<<< ....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<... .>>..<<<<.....>>>>....<..>...>>>>>>>>>>>>>..<<.<.. .<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>>>>.. ...>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>... <<<.....>>>......>>>>>>......>.>>..<<<<<<....<<<<< ....>>>>><<<<<<<<<.....<<<<<<<<<....<<...<<<<<<<<. ..<<<<<<......>>>>.>>...>>>>>>>>..>>.....>>>>>>>>> .....>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<< <......>>>...<<<<.<<<...<<<(((.....<<<<<<......... ..<<..<<<<<<<<<........<<<<<.<<...<<<<.......>>>>. ..>>.........<<......>>...>>>>>....>>>>>>>>>.>>... .......)))......>>>>>>.>>>...>>>>>>><<<<<<<<.....> >>>>>>>....>>>>>>..<<<<<...<<<......<<<<<.<<<....> >>>>>>>...>>>..>>>>>........>>>>>><......<<.....<< <<<<.......>>>>>><<<<....<<<<<.<<...<<<<<<...<<... ..>>.>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>. ..>>...<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<... .<<<<<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<< <<<<<<<<<<<<.<<.....>>>>>>>>>.....>>>>>>>>>..>>><. ..<<<<<..>>>>>.....>>>>>>...>>>..>>>>>.........>>> >...>>...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.< <<<<....>>>>>..>>>>..<<<<....<<<<<<<<.<<.........< .....<<<<<.....<..>......>>>>><<<<<<<<<<<<.....>>> >>>>>>>>>............<<<<<<<<<..<<<.........>>>..< <<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<< <<<<..<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..> >>>><<<<<<.......>>>>>>........<...........<<<<<<. ....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>> >>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<<. <<<.........<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<<<<<< <<<<<<<...........<<<<<..<<<......<<<<<<<<....>>>> >>>>...>>>............>>>>>..>>>>>>>>>>>>>>>>...<< <<<....>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<< <<<...........>>>>>>..<<...<<<<<<<...<<<<<<....... >>>>>>.....<<...(((>>....>>>>>>>...<<<<..<<<...... >>>..>>>>.<<<....>>>.>>))).......<<<<<<<.<<..)))). .>>>>>>>>>.............>>>>..>>>>>>.......<<<<.<.< <<<<<...<<.......>>...>>>>>>...>>>>.>.......<<<<<. <<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>> .....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>..... ...>>>>>>>>>>>....<<<<<<<...<<<<..<<<<<<<......... ......>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>> ...>>>>>...>>>>.>>>>>...<<<.....<<<<...........>>> >.....>>>.>>>>.......>>>>>>>...<<<.....>>>.....<<< <<<<<<.......>>>>>....<<<<<<<<.<<<....<<<<<....>>> >>...>>>..>>>>>.>>>...>>>>....>>>

Receptor-Ligand Complex Structure Global view Local view Structure summary [Spin on] [Spin off] [Reset] [High quality] [Low quality] [White background] [Black background] [Spin on] [Spin off] [Reset] [High quality] [Low quality] [White background] [Black background] PDB 6bz7 Ribosomal ambiguity (ram) mutations promote the open (off) to closed (on) transition and thereby increase miscoding. Resolution 3.68 Å Binding residue (original residue number in PDB) R5 R6 K8 Y9 K11 Q13 R14 G15 R16 K18 K22 G23 Y26 F29 W41 Q46 A49 R56 K63 R67 F69 D71 Y74 K76 K77 L79 V81 R82 M83 G84 K85 G86 R101 I120 H123 K124 P126 K128 Binding residue (residue number reindexed from 1) R5 R6 K8 Y9 K11 Q13 R14 G15 R16 K18 K22 G23 Y26 F29 W41 Q46 A49 R56 K63 R67 F69 D71 Y74 K76 K77 L79 V81 R82 M83 G84 K85 G86 R101 I120 H123 K124 P126 K128

Enzymatic activity Enzyme Commision number ?

Gene Ontology Molecular Function GO:0000049 tRNA binding GO:0003735 structural constituent of ribosome GO:0019843 rRNA binding

	Biological Process
GO:0006412	translation

	Cellular Component
GO:0005840	ribosome
GO:0022625	cytosolic large ribosomal subunit
GO:1990904	ribonucleoprotein complex

View graph for Molecular Function

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View graph for Cellular Component