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Structure of PDB 1ej9 Chain A Binding Site BS02

Receptor Information >1ej9 Chain A (length=483) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure] WKWWEEERYPEGIKWKFLEHKGPVFAPPYEPLPENVKFYYDGKVMKLSPK AEEVATFFAKMLDHEYTTKEIFRKNFFKDWRKEMTNEEKNIITNLSKCDF TQMSQYFKAQTEARKQMSKEEKLKIKEENEKLLKEYGFCIMDNHKERIAN FKIEPPGLFRGRGNHPKMGMLKRRIMPEDIIINCSKDAKVPSPPPGHKWK EVRHDNKVTWLVSWTENIQGSIKYIMLNPSSRIKGEKDWQKYETARRLKK CVDKIRNQYREDWKSKEMKVRQRAVALYFIDKLALRAGNEKEEGETADTV GCCSLRVEHINLHPELDGQEYVVEFDFLGKDSIRYYNKVPVEKRVFKNLQ LFMENKQPEDDLFDRLNTGILNKHLQDLMEGLTAKVFRTYNASITLQQQL KELTAPDENIPAKILSYNRANRAVAILCNHQIALGTSKLNFLDPRITVAW CKKWGVPIEKIYNKTQREKFAWAIDMADEDYEF

Ligand information >1ej9 Chain D (length=22) [Search DNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure] aaaaatttttctgagtcttttt

Receptor-Ligand Complex Structure Global view Local view Structure summary [Spin on] [Spin off] [Reset] [High quality] [Low quality] [White background] [Black background] [Spin on] [Spin off] [Reset] [High quality] [Low quality] [White background] [Black background] PDB 1ej9 Novel insights into catalytic mechanism from a crystal structure of human topoisomerase I in complex with DNA. Resolution 2.6 Å Binding residue (original residue number in PDB) E356 P357 R362 G363 R364 H367 K425 A489 G490 N491 K493 T501 K532 D533 T585 A586 K587 N745 T747 Binding residue (residue number reindexed from 1) E154 P155 R160 G161 R162 H165 K223 A287 G288 N289 K291 T299 K330 D331 T383 A384 K385 N463 T465

Enzymatic activity Enzyme Commision number 5.6.2.1: DNA topoisomerase.

Gene Ontology Molecular Function GO:0003677 DNA binding GO:0003917 DNA topoisomerase type I (single strand cut, ATP-independent) activity

	Biological Process
GO:0006265	DNA topological change

	Cellular Component
GO:0005694	chromosome

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