BioLiP

Structure of PDB 7u7r Chain A Binding Site BS02

Receptor Information

>7u7r Chain A (length=430) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

GPHMATGQDRVVALVDMDCFFVQVEQRQNPHLRNKPCAVVQYKSWKGGGI
IAVSYEARAFGVTRSMWADDAKKLCPDLLLAQVRESRGKANLTKYREASV
EVMEIMSRFAVIERASIDEAYVDLTSAVQERLQKLQGQPISADLLPSTYI
EGLPQGPTVQKEGMRKQGLFQWLDSLQIDNLTSPDLQLTVGAVIVEEMRA
AIERETGFQCSAGISHNKVLAKLACGLNKPNRQTLVSHGSVPQLFSQMPI
RKIRSLGGKLGASVIEILGIEYMGELTQFTESQLQSHFGEKNGSWLYAMC
RGIEHDPVKPRQLPKTIGCSKNFPGKTALATREQVQWWLLQLAQELEERL
TKDRNDNDRVATQLVVSIRVQGDKRLSSLRRCCALTRYDAHKMSHDAFTV
IKNCNTSGIQTEWSPPLTMLFLCATKFSAS

Ligand information

>7u7r Chain P (length=8) [Search DNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

agcgtcat

Receptor-Ligand Complex Structure

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Structure summary

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PDB	7u7r In crystallo observation of three metal ion promoted DNA polymerase misincorporation.
Resolution	1.64 Å
Binding residue (original residue number in PDB)	R61 S257 G259 G260 K261 L262 R377 L381 R382 C384
Binding residue (residue number reindexed from 1)	R64 S255 G257 G258 K259 L260 R375 L379 R380 C382

Enzymatic activity

Enzyme Commision number

2.7.7.7: DNA-directed DNA polymerase.

Gene Ontology

	Molecular Function
GO:0003684	damaged DNA binding

	Biological Process
GO:0006281	DNA repair

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Molecular Function

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Biological Process

PDB	RCSB:7u7r, PDBe:7u7r, PDBj:7u7r
PDBsum	7u7r
PubMed	35487947
UniProt	Q9Y253\|POLH_HUMAN DNA polymerase eta (Gene Name=POLH)