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BioLiP

Structure of PDB 1efa Chain B Binding Site BS02

Receptor Information
>1efa Chain B (length=330) Species: 562 (Escherichia coli) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KPVTLYDVAEYAGVSYQTVSRVVNQASHVSAKTREKVEAAMAELNYIPNR
VAQQLAGKQSLLIGVATSSLALHAPSQIVAAIKSRADQLGASVVVSMVER
SGVEACKTAVHNLLAQRVSGLIINYPLDDQDAIAVEAACTNVPALFLDVS
DQTPINSIIFSHEDGTRLGVEHLVALGHQQIALLAGPLSSVSARLRLAGW
HKYLTRNQIQPIAEREGDWSAMSGFQQTMQMLNEGIVPTAMLVANDQMAL
GAMRAITESGLRVGADISVVGYDDTEDSSCYIPPLTTIKQDFRLLGQTSV
DRLLQLSQGQAVKGNQLLPVSLVKRKTTLA
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB1efa A closer view of the conformation of the Lac repressor bound to operator.
Resolution2.6 Å
Binding residue
(original residue number in PDB)
V15 S16 Y17 T19 R22 H29 V30 S31 T34 L56 A57
Binding residue
(residue number reindexed from 1)
V14 S15 Y16 T18 R21 H28 V29 S30 T33 L55 A56
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0000976 transcription cis-regulatory region binding
GO:0000987 cis-regulatory region sequence-specific DNA binding
GO:0001217 DNA-binding transcription repressor activity
GO:0003677 DNA binding
GO:0003700 DNA-binding transcription factor activity
GO:0042802 identical protein binding
Biological Process
GO:0006355 regulation of DNA-templated transcription
GO:0045892 negative regulation of DNA-templated transcription
Cellular Component
GO:0005829 cytosol

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Molecular Function

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Biological Process

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Cellular Component
External links
PDB RCSB:1efa, PDBe:1efa, PDBj:1efa
PDBsum1efa
PubMed10700279
UniProtP03023|LACI_ECOLI Lactose operon repressor (Gene Name=lacI)

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