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BioLiP

Structure of PDB 4gl2 Chain B Binding Site BS02

Receptor Information
>4gl2 Chain B (length=615) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
LQLRPYQMEVAQPALEGKNIIICLPTGCGKTRVAVYIAKDHLDKKKKASE
PGKVIVLVNKVLLVEQLFRKEFQPFLKKWYRVIGLSGLKISFPEVVKSCD
IIISTAQILENSLLNGVQLSDFSLIIIDECHHTNKEAVYNNIMRHYLMQK
LKNNRLKKVIPLPQILGLTASPGVGGATKQAKAEEHILKLCANLDAFTIK
TVKENLDQLKNQIQEPCKKFAIPFKEKLLEIMTRIQTYCQMSPMSDFGTQ
PYEQWAIQMEKKAAKEGNRKERVCAEHLRKYNEALQINDTIRMIDAYTHL
ETFYNEEKDKKFLDETDRFLMTLFFENNKMLKRLAENPNEKLTKLRNTIM
EQYTRTEESARGIIFTKTRQSAYALSQWITENEKFAEVKAHHLIGAGHSS
EFKPMTQNEQKEVISKFRTGKLLIATTVAEEGLDIKECNIVIRYGLVTNE
IAMVQARGDESTYVLVAHSGSGVIERETVNDFREKMMYKAIHCVQNMKPE
EYAHKILELQMQSIMEKKMKPSLITFLCKNCSVLACSGEDIHVIEKMHHV
NMTPEFKELYIVRGEIICKCGQAWGTMMVHLPCLKIRNFVVVFKNNSTKK
QYKKWVELPITFPNL
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB4gl2 Structural Basis for dsRNA Recognition, Filament Formation, and Antiviral Signal Activation by MDA5.
Resolution3.557 Å
Binding residue
(original residue number in PDB)		N364 K365 V366 T413 Q415 N419 Q580 K726 R728 I755 G756 S761 V791 M926 H927 H974
Binding residue
(residue number reindexed from 1)		N59 K60 V61 T105 Q107 N111 Q254 K367 R369 I394 G395 S400 V428 M547 H548 H580
Enzymatic activity
Enzyme Commision number 3.6.4.13: RNA helicase.
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0005524 ATP binding
GO:0016787 hydrolase activity

View graph for
Molecular Function
External links
PDB RCSB:4gl2, PDBe:4gl2, PDBj:4gl2
PDBsum4gl2
PubMed23273991
UniProtQ9BYX4|IFIH1_HUMAN Interferon-induced helicase C domain-containing protein 1 (Gene Name=IFIH1)

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