Online Services

●I-TASSER ●I-TASSER-MTD ●C-I-TASSER ●CR-I-TASSER ●QUARK ●C-QUARK ●LOMETS ●MUSTER ●CEthreader ●SEGMER ●DeepFold ●DeepFoldRNA ●FoldDesign ●COFACTOR ●COACH ●MetaGO ●TripletGO ●IonCom ●FG-MD ●ModRefiner ●REMO ●DEMO ●DEMO-EM ●SPRING ●COTH ●Threpp ●PEPPI ●BSpred ●ANGLOR ●EDock ●BSP-SLIM ●SAXSTER ●FUpred ●ThreaDom ●ThreaDomEx ●EvoDesign ●BindProf ●BindProfX ●SSIPe ●GPCR-I-TASSER ●MAGELLAN ●ResQ ●STRUM ●DAMpred

●TM-score ●TM-align ●US-align ●MM-align ●RNA-align ●NW-align ●LS-align ●EDTSurf ●MVP ●MVP-Fit ●SPICKER ●HAAD ●PSSpred ●3DRobot ●MR-REX ●I-TASSER-MR ●SVMSEQ ●NeBcon ●ResPRE ●TripletRes ●DeepPotential ●WDL-RF ●ATPbind ●DockRMSD ●DeepMSA ●FASPR ●EM-Refiner ●GPU-I-TASSER

●BioLiP ●E. coli ●GLASS ●GPCR-HGmod ●GPCR-RD ●GPCR-EXP ●Tara-3D ●TM-fold ●DECOYS ●POTENTIAL ●RW/RWplus ●EvoEF ●HPSF ●THE-DB ●ADDRESS ●Alpaca-Antibody ●CASP7 ●CASP8 ●CASP9 ●CASP10 ●CASP11 ●CASP12 ●CASP13 ●CASP14

Structure of PDB 7egh Chain B Binding Site BS02

Receptor Information >7egh Chain B (length=963) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure] GFESPRPYKLTHQVVCINNINFQRKSVVGFVELTIFPTVANLNRIKLNSK QCRIYRVRINDLEAAFIYNDPTLEVCHSESKQRNLNYFSNAYAAAVSAVD PDAGNGELCIKVPSELWKHVDELKVLKIHINFSLDQPKGGLHFVVPSVEG SMAERGAHVFSCGYQNSTRFWFPCVDSYSELCTWKLEFTVDAAMVAVSNG DLVETVYTHDMRKKTFHYMLTIPTAASNISLAIGPFEILVDPYMHEVTHF CLPQLLPLLKHTTSYLHEVFEFYEEILTCRYPYSCFKTVFIDEAYVEVAA YASMSIFSTNLLHSAMIIDETPLTRRCLAQSLAQQFFGCFISRMSWSDEW VLKGISGYIYGLWMKKTFGVNEYRHWIKEELDKIVAYELKTGGVLLHPIF NPASHLHFSIKHPHTLSWEYYSMFQCKAHLVMRLIENRISMEFMLQVFNK LLSLASTASSQKFQSHMWSQMLVSTSGFLKSISNVSGKDIQPLIKQWVDQ SGVVKFYGSFAFNRKRNVLELEIKQDYTSPGTQKYVGPLKVTVQELDGSF NHTLQIEENSLKHDIPCHSKSRRNKKKKIPLMNGEEVDMDLSAMDADSPL LWIRIDPDMSVLRKVEFEQADFMWQYQLRYERDVVAQQESILALEKFPTP ASRLALTDILEQEQCFYRVRMSACFCLAKIANSMVSTWTGPPAMKSLFTR MFCCKSCPNIVKTNNFMSFQSYFLQKTMPVAMALLRDVHNLCPKEVLTFI LDLIKYNDNRKNKFSDNYYRAEMIDALANSVTPAVSVNNEVRTLDNLNPD VRLILEEITRFLNMEKLLPSYRHTITVSCLRAIRVLQKNGHVPSDPALFK SYAEYGHFVDIRIAALEAVVDYTKVDRSYEELQWLLNMIQNDPVPYVRHK ILNMLTKNPPFTKNMESPLCNEALVDQLWKLMNSGTSHDWRLRCGAVDLY FTLFGLSRPSCLP

Ligand information >7egh Chain Y (length=45) [Search DNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure] cgtaggcacgtctgctcggctcgagtgttcgatcgcgactgagga

Receptor-Ligand Complex Structure Global view Local view Structure summary [Spin on] [Spin off] [Reset] [High quality] [Low quality] [White background] [Black background] [Spin on] [Spin off] [Reset] [High quality] [Low quality] [White background] [Black background] PDB 7egh Structural insights into preinitiation complex assembly on core promoters. Resolution 3.04 Å Binding residue (original residue number in PDB) S594 K595 Binding residue (residue number reindexed from 1) S569 K570

Enzymatic activity Enzyme Commision number ?

Gene Ontology Molecular Function GO:0000976 transcription cis-regulatory region binding GO:0003682 chromatin binding GO:0005515 protein binding GO:0016251 RNA polymerase II general transcription initiation factor activity

	Biological Process
GO:0000086	G2/M transition of mitotic cell cycle
GO:0006282	regulation of DNA repair
GO:0006357	regulation of transcription by RNA polymerase II
GO:0006367	transcription initiation at RNA polymerase II promoter
GO:0014070	response to organic cyclic compound
GO:0042789	mRNA transcription by RNA polymerase II
GO:0045893	positive regulation of DNA-templated transcription
GO:0051123	RNA polymerase II preinitiation complex assembly
GO:0060261	positive regulation of transcription initiation by RNA polymerase II

	Cellular Component
GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005669	transcription factor TFIID complex
GO:0033276	transcription factor TFTC complex

View graph for Molecular Function

View graph for Biological Process

View graph for Cellular Component