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BioLiP

Structure of PDB 1iht Chain H Binding Site BS02

Receptor Information
>1iht Chain H (length=258) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
IVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPW
DKNFTENDLLVRIGKHSRTRYERNIEKISMLEKIYIHPRYNWRENLDRDI
ALMKLKKPVAFSDYIHPVCLPDRETAASLLQAGYKGRVTGWGNLKETWTA
NVGKGQPSVLQVVNLPIVERPVCKDSTRIRITDNMFCAGYKPDEGKRGDA
CEGDSGGPFVMKSPFNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWI
QKVIDQFG
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB1iht Crystal structure of the complex of human alpha-thrombin and nonhydrolyzable bifunctional inhibitors, hirutonin-2 and hirutonin-6.
Resolution2.1 Å
Binding residue
(original residue number in PDB)		F34 Q38 L40 L41 Y60A K60F R67 R73 T74 Y76 D189 G193 S195 W215 G216 G246
Binding residue
(residue number reindexed from 1)		F19 Q24 L26 L27 Y47 K52 R62 R68 T69 Y71 D199 G203 S205 W227 G228 G258
Enzymatic activity
Enzyme Commision number 3.4.21.5: thrombin.
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
GO:0005509 calcium ion binding
Biological Process
GO:0006508 proteolysis
GO:0007596 blood coagulation

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Molecular Function
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Biological Process
External links
PDB RCSB:1iht, PDBe:1iht, PDBj:1iht
PDBsum1iht
PubMed8272424
UniProtP00734|THRB_HUMAN Prothrombin (Gene Name=F2)

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