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Structure of PDB 5g08 Chain A Binding Site BS03

Receptor Information >5g08 Chain A (length=180) Species: 7227 (Drosophila melanogaster) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure] KNSKLKQDTIDRLTTDTYFTEKEIRQWHKGFLKDCPNGLLTEQGFIKIYK QFFPDGDPSKFASLVFRVFDENNDGAIEFEEFIRALSITSRGNLDEKLHW AFRLYDVDNDGYITREEMYNIVDAIYQMVGQQPQTEDENTPQKRVDKIFD QMDKNHDDRLTLEEFREGSKADPRMVQALS

Ligand information Ligand ID CA InChI InChI=1S/Ca/q+2 InChIKey BHPQYMZQTOCNFJ-UHFFFAOYSA-N SMILES Software SMILES CACTVS 3.341 [Ca++] ACDLabs 10.04 OpenEye OEToolkits 1.5.0 [Ca+2] Formula Ca Name CALCIUM ION ChEMBL DrugBank DB14577 ZINC PDB chain 5g08 Chain A Residue 1186 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure Global view Local view Structure summary [Spin on] [Spin off] [Reset] [High quality] [Low quality] [White background] [Black background] [Spin on] [Spin off] [Reset] [High quality] [Low quality] [White background] [Black background] PDB 5g08 Interference of the complex between NCS-1 and Ric8a with phenothiazines regulates synaptic function and is an approach for fragile X syndrome. Resolution 1.52 Å Binding residue (original residue number in PDB) D109 D111 D113 Y115 E120 Binding residue (residue number reindexed from 1) D106 D108 D110 Y112 E117 Annotation score 4

Enzymatic activity Enzyme Commision number ?

Gene Ontology Molecular Function GO:0005509 calcium ion binding GO:0005515 protein binding GO:0008048 calcium sensitive guanylate cyclase activator activity GO:0046872 metal ion binding

	Biological Process
GO:0007268	chemical synaptic transmission
GO:0007269	neurotransmitter secretion
GO:0007528	neuromuscular junction development
GO:0016192	vesicle-mediated transport
GO:0046928	regulation of neurotransmitter secretion

	Cellular Component
GO:0005737	cytoplasm
GO:0008021	synaptic vesicle

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