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Structure of PDB 5twr Chain A Binding Site BS03

Receptor Information >5twr Chain A (length=327) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure] MPAYACQRPTPLTHHNTGLSEALEILAEAAGFEGSEGRLLTFCRAASVLK ALPSPVTTLSQLQGLPHFGEHSSRVVQELLEHGVCEEVERVRRSERYQTM KLFTQIFGVGVKTADRWYREGLRTLDDLREQPQKLTQQQKAGLQHHQDLS TPVLRSDVDALQQVVEEAVGQALPGATVTLTGGFRRGKLQGADVDFLITH PKEGQEAGLLPRVMCRLQDQGLILYHQHAFERSFCIFRLPQPGSWKAVRV DLVVAPVSQFPFALLGWTGSKLFQRELRRFSRKEKGLWLNSHGLFDPEQK TFFQAASEEDIFRHLGLEYLPPEQRNA

Ligand information >5twr Chain D (length=4) [Search DNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure] gccg

Receptor-Ligand Complex Structure Global view Local view Structure summary [Spin on] [Spin off] [Reset] [High quality] [Low quality] [White background] [Black background] [Spin on] [Spin off] [Reset] [High quality] [Low quality] [White background] [Black background] PDB 5twr Structural accommodation of ribonucleotide incorporation by the DNA repair enzyme polymerase Mu. Resolution 1.9 Å Binding residue (original residue number in PDB) G174 R175 T178 F179 H204 G206 H208 S209 Binding residue (residue number reindexed from 1) G37 R38 T41 F42 H67 G69 H71 S72

Enzymatic activity Catalytic site (original residue number in PDB) D330 D332 D418 Catalytic site (residue number reindexed from 1) D193 D195 D251 Enzyme Commision number 2.7.7.7: DNA-directed DNA polymerase.

Gene Ontology Molecular Function GO:0003677 DNA binding GO:0003887 DNA-directed DNA polymerase activity GO:0016779 nucleotidyltransferase activity GO:0034061 DNA polymerase activity

	Biological Process
GO:0006281	DNA repair

	Cellular Component
GO:0005634	nucleus

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