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Structure of PDB 5nnu Chain D Binding Site BS03

Receptor Information >5nnu Chain D (length=230) Species: 37296 (Human gammaherpesvirus 8) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure] DLLLAPKWISFLSLSSFLKQKLLSLLRQIRELRLTTTVYPPQDKLMWWSH CCDPEDIKVVILGQDPYHKGQATGLAFSVDPQCQVPPSLRSIFRELEASV PNFSTPSHGCLDSWARQGVLLLNTVLTVEKGRAGSHEGLGWDWFTSFIIS SISSKLEHCVFLLWGRKAIDRTPLINAQKHLVLTAQHPSPLASLGGRHSR WPRFQGCNHFNLANDYLTRHRRETVDWGLL

Ligand information >5nnu Chain X (length=11) [Search DNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure] aagataacatt

Receptor-Ligand Complex Structure Global view Local view Structure summary [Spin on] [Spin off] [Reset] [High quality] [Low quality] [White background] [Black background] [Spin on] [Spin off] [Reset] [High quality] [Low quality] [White background] [Black background] PDB 5nnu A structurally conserved motif in gamma-herpesvirus uracil-DNA glycosylases elicits duplex nucleotide-flipping. Resolution 2.97 Å Binding residue (original residue number in PDB) R120 P216 S219 L220 R223 Binding residue (residue number reindexed from 1) R94 P190 S193 L194 R197

Enzymatic activity Catalytic site (original residue number in PDB) D91 Y93 F103 H213 Catalytic site (residue number reindexed from 1) D65 Y67 F77 H187 Enzyme Commision number 3.2.2.27: uracil-DNA glycosylase.

Gene Ontology Molecular Function GO:0004844 uracil DNA N-glycosylase activity GO:0016787 hydrolase activity GO:0016799 hydrolase activity, hydrolyzing N-glycosyl compounds

	Biological Process
GO:0006281	DNA repair
GO:0006284	base-excision repair
GO:0097510	base-excision repair, AP site formation via deaminated base removal

	Cellular Component
GO:0042025	host cell nucleus

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