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BioLiP

Structure of PDB 8d4a Chain A Binding Site BS07

Receptor Information
>8d4a Chain A (length=1207) Species: 1539066 (Sulfuricurvum sp. PC08-66) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MLHAFTNQYQLSKTLRFGATLKEDEKKCKSHEELKGFVDISYENMKSSAT
ENELVKKCERCYSEIVKFHNAWEKIYYRTDQIAVYKDFYRQLSRKARFDA
GKQNSQLITLASLCGMYQGAKLSRYITNYWKDNITRQKSFLKDFSQQLHQ
YTRALEKSDKAHTKPNLINFNKTFMVLANLVNEIVIPLSNGAISFPNISK
LEDGEESHLIEFALNDYSQLSELIGELKDAIATNGGYTPFAKVTLNHYTA
EQKPHVFKNDIDAKIRELKLIGLVETLKGKSSEQIEEYFSNLDKFSTYND
RNQSVIVRTQCFKYKPIPFLVKHQLAKYISEPNGWDEDAVAKVLDAVGAI
RSPAHDYANNQEGFDLNHYPIKVAFDYAWEQLANSLYTTVTFPQEMCEKY
LNSIYGCEVSKEPVFKFYADLLYIRKNLAVLEHKNNLPSNQEEFICKINN
TFENIVLPYKISQFETYKKDILAWINDGHDHKKYTDAKQQLGFIRGGLKG
RINPYTKLTNEFKQISSTYGKTFAELRDKFKEKNEITKITHFGIIIEDKN
RDRYLLASELKHEQINHVSTILNKLDKSSEFITYQVKSLTSKTLIKLIKN
HTTKKGAISPYADFHTSKTGFNKNEIEKNWDNYKREQVLVEYVKDCLTDS
TMAKNQNWAEFGWNFEKCNSYEDIEHEIDQKSYLLQSDTISKQSIASLVE
GGCLLLPIINQDITSKERKDKNQFSKDWNHIFEGSKEFRLHPEFAVSYRT
PIEGYPVQKRYGRLQFVCAFNAHIVPQNGEFINLKKQIENFNDEDVQKRN
VTEFNKKVNHALSDKEYVVIGIDRGLKQLATLCVLDKRGKILGDFEIYKK
EFVRAEKRSESHWEHTQAETRHILDLSNLRVETTIEGKKVLVDQSLTLVK
KNRDTPDEEATEENKQKIKLKQLSYIRKLQHKMQTNEQDVLDLINNEPSD
EEFKKRIEGLISSFGEGQKYADLPINTMREMISDLQGVIARGNNQTEKNK
IIELDAADNLKQGIVANMIGIVNYIFAKYSYKAYISLEDLSRAYGGAKSG
YDGRYLPSTSQDEDVDFKEQQNQMLAGLGTYQFFEMQLLKKLQKIQSDNT
VLRFVPAFRSADNYRNILRLEETKYKSKPFGVVHFIDPKFTSKKCPVCSK
TNVYRDKDDILVCKECGFRSDSQLKERENNIHYIHNGDDNGAYHIALKSV
ENLIQMK
Ligand information
Ligand IDMG
InChIInChI=1S/Mg/q+2
InChIKeyJLVVSXFLKOJNIY-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mg+2]
CACTVS 3.341[Mg++]
FormulaMg
NameMAGNESIUM ION
ChEMBL
DrugBankDB01378
ZINC
PDB chain8d4a Chain A Residue 1303 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8d4a RNA targeting unleashes indiscriminate nuclease activity of CRISPR-Cas12a2.
Resolution2.74 Å
Binding residue
(original residue number in PDB)		D848 D1213
Binding residue
(residue number reindexed from 1)		D823 D1188
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology

View graph for
Molecular Function
External links

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