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Structure of PDB 1if6 Chain A

Receptor sequence >1if6A (length=258) Species: 9606 (Homo sapiens) [Search protein sequence] HHWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYD QATSLRILNNGHAFNVEFDDSQDKAVLKGGPLDGTYRLIQFHFHWGSLDG QGSEHTVDKKKYAAELHLVHWNTKYGDFGKAVQQPDGLAVLGIFLKVGSA KPGLQKVVDVLDSIKTKGKSADFTNFDPRGLLPESLDYWTYPGSLTTPPL LECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELMVDNWRPAQPLKN RQIKASFK

3D structure PDB 1if6 Binding of Fluorine Substituted Benzenesulfonamides to Carbonic Anhydrase II Chain A Resolution 2.09 Å 3D structure Catalytic site residues are labeled in the structure [Spin on] [Spin off] [Reset orientation] [High quality] [Low quality] [White background] [Black background] [Download] [Download structure with residue number starting from 1]

Enzymatic activity Catalytic site (original residue number in PDB) H64 H94 H96 E106 H119 T199 Catalytic site (residue number reindexed from 1) H62 H92 H94 E104 H117 T196 Enzyme Commision number 4.2.1.1: carbonic anhydrase. 4.2.1.69: cyanamide hydratase.

Interaction with ligand Site # Ligand Ligand chain Binding residues on receptor (original residue number in PDB) Binding residues on receptor (residue number reindexed from 1) Binding affinity BS01 ZN A H94 H96 H119 H92 H94 H117 BS02 FBU A H94 H96 H119 V121 L198 T199 T200 H92 H94 H117 V119 L195 T196 T197

Gene Ontology Molecular Function GO:0004064 arylesterase activity GO:0004089 carbonate dehydratase activity GO:0005515 protein binding GO:0008270 zinc ion binding GO:0016829 lyase activity GO:0018820 cyanamide hydratase activity GO:0046872 metal ion binding

	Biological Process
GO:0002009	morphogenesis of an epithelium
GO:0006730	one-carbon metabolic process
GO:0015670	carbon dioxide transport
GO:0032230	positive regulation of synaptic transmission, GABAergic
GO:0032849	positive regulation of cellular pH reduction
GO:0038166	angiotensin-activated signaling pathway
GO:0044070	regulation of monoatomic anion transport
GO:0046903	secretion
GO:0051453	regulation of intracellular pH
GO:0070050	neuron cellular homeostasis
GO:2001150	positive regulation of dipeptide transmembrane transport
GO:2001225	regulation of chloride transport

	Cellular Component
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0043209	myelin sheath
GO:0045177	apical part of cell
GO:0070062	extracellular exosome

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