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Structure of PDB 1x7w Chain A

Receptor sequence >1x7wA (length=369) Species: 9606 (Homo sapiens) [Search protein sequence] PQFPGASAEFIDKLEFIQPNVISGIPIYRVMDRQGQIINPSEDPHLPKEK VLKLYKSMTLLNTMDRILYESQRQGRISFYMTNYGEEGTHVGSAAALDNT DLVFGQYREAGVLMYRDYPLELFMAQCYGNISDLGKGRQMPVHYGCKERH FVTISSPLATQIPQAVGAAYAAKRANANRVVICYFGEGAASEGDAHAGFN FAATLECPIIFFCRNNGYAISTPTSEQYRGDGIAARGPGYGIMSIRVDGN DVFAVYNATKEARRRAVAENQPFLIEAMTYRDHPISRLRHYLLSQGWWDE EQEKAWRKQSRRKVMEAFEQAERKPKPNPNLLFSDVYQEMPAQLRKQQES LARHLQTYGEHYPLDHFDK

3D structure PDB 1x7w Molecular mechanism for regulation of the human mitochondrial branched-chain alpha-ketoacid dehydrogenase complex by phosphorylation Chain A Resolution 1.73 Å 3D structure Catalytic site residues are labeled in the structure [Spin on] [Spin off] [Reset orientation] [High quality] [Low quality] [White background] [Black background] [Download] [Download structure with residue number starting from 1]

Enzymatic activity Catalytic site (original residue number in PDB) E76 S162 R287 Catalytic site (residue number reindexed from 1) E70 S156 R281 Enzyme Commision number 1.2.4.4: 3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring).

Interaction with ligand Site # Ligand Ligand chain Binding residues on receptor (original residue number in PDB) Binding residues on receptor (residue number reindexed from 1) Binding affinity BS01 MN A E193 N222 Y224 E187 N216 Y218 BS02 TPP A R114 S162 L164 G192 E193 G194 A195 R220 N222 Y224 A225 I226 R108 S156 L158 G186 E187 G188 A189 R214 N216 Y218 A219 I220

Gene Ontology Molecular Function GO:0003863 3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring) activity GO:0005515 protein binding GO:0016491 oxidoreductase activity GO:0016624 oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor GO:0016831 carboxy-lyase activity GO:0046872 metal ion binding GO:0047101 branched-chain alpha-keto acid dehydrogenase activity

	Biological Process
GO:0009083	branched-chain amino acid catabolic process

	Cellular Component
GO:0005739	mitochondrion
GO:0005759	mitochondrial matrix
GO:0045252	oxoglutarate dehydrogenase complex
GO:0160157	branched-chain alpha-ketoacid dehydrogenase complex

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